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Biomedical subjects

S Sakai

Publications and source records attributed to S Sakai.

At least 523 records · Page 29Linked to original sources
PubMed1988

[A clinical study of xanthogranulomatous pyelonephritis with special emphasis on the differential preoperative diagnosis between xanthogranulomatous pyelonephritis and renal cell carcinoma].

An accurate preoperative diagnosis of xanthogranulomatous pyelonephritis is difficult because of its clinical and radiological similarities to renal cell carcinoma. We report two cases of xanthogranulomatous pyelonephritis. Furthermore, in an attempt to clarify the clinical distinction between this entity and renal cell carcinoma, we summarize the clinical characteristics of 143 cases with xanthogranulomatous pyelonephritis in the literature and 126 cases with renal cell carcinoma experienced in our clinic. According to the clinical reviews, several characteristics of xanthogranulomatous pyelonephritis were revealed. 1) Presence of history of pyelonephritis. 2) gamma-globulinemia in blood chemistry. 3) Non-visualizing kidney on the excretory urogram. 4) Hypovascular or avascular features and dilatation of renal capsular arteries on angiogram. 5) Heterogenous renal mass and thickness of Gerota's fascia on computed tomogram. 6) Positive uptake of renal mass in Ga-scintigram. When some of these features are found in the renal mass, the case could be of xanthogranulomatous pyelonephritis and therefore a kidney preserving operation should be considered.

Carcinoma, Renal Cell↗
PubMed1988

[In vitro activity of minocycline against Chlamydia trachomatis clinical isolates and clinical efficacy of minocycline to C. trachomatis associated nongonococcal urethritis].

The in vitro activity of minocycline (MINO) against Chlamydia trachomatis and its efficacy in the treatment of C. trachomatis-associated nongonococcal urethritis were investigated. Six isolates of C. trachomatis were inhibited at 0.06 micrograms/ml of MINO and 5 isolates at 0.03 micrograms/ml. All cases received oral MINO twice daily for 7 or more days in doses of 100 mg. In 5 of 31 cases, 2 g of spectinomycin was intramuscularly administrated together with MINO only once. C. trachomatis was eliminated in all cases tested. Excellent results were obtained in 26 cases (84%); urethral discharge and polymorphonuclear cells (PMN) disappeared or decreased to normal levels (3 cells/hpf or less) in these cases. Ureaplasma urealyticum was isolated from 8 cases, 7 of which became free of ureaplasmal infection. MINO seemed to be less effective on the decrease of PMN in the urethral smear in cases infected coincidentally with C. trachomatis and U. urealyticum than in cases infected with C. trachomatis alone. No subjective side effects were observed in any of the 31 cases studied. In conclusion, MINO was a useful antimicrobial agent for the treatment of C. trachomatis- and U. urealyticum-associated nongonococcal urethritis.

Adult↗
PubMed1988

Effects of nilvadipine on the cardiovascular system in experimental animals.

The effects of 5-isopropyl 3-methyl 2-cyano-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate (nilvadipine, FR 34235, FK 235) on the cardiovascular system were investigated in isolated organs and whole animals. 1. Nilvadipine inhibited Ca2+-induced contractions of isolated dog coronary artery in high-K+, Ca2+-free medium, and the pA2 value was 10.64. In this effect, nilvadipine was 18 times more potent than nifedipine and 525 times more potent than diltiazem. In contrast, its inhibitory effect on Ca2+-induced contractions of isolated guinea pig atria was weaker (pA2:8.2): only twice that of nifedipine and 25 times that of diltiazem. 2. Nilvadipine also inhibited K+-induced 45Ca2+ uptake in isolated dog coronary arteries and isolated guinea pig atria. In the coronary arteries, the IC50 value of nilvadipine was 2.7 x 10(-10) mol/l, which was, respectively 17, 8, and 589 times lower than that of nifedipine, nicardipine and diltiazem. In the atria, on the other hand, the IC50 value of nilvadipine was 4.4 x 10(-9) mol/l, almost the same as that of nifedipine or nicardipine, and 47 times lower than that of diltiazem. These 45Ca2+ uptake inhibitory effects of the drugs were consistent with their effects on mechanical response in both tissues. 3. Nilvadipine (2.6 x 10(-10) mol/l and higher) dose-dependently inhibited ergometrine (ergonovine)-, serotonin-, and norepinephrine-induced contractions of isolated dog coronary artery, and its effects were 2 to 450 times more potent than those of nifedipine, nicardipine and diltiazem. 4. Nilvadipine (2.6 x 10(-8) mol/l or more, 32 micrograms/heart or more), like nifedipine, produced negative inotropic and chronotropic effects in isolated guinea pig atria and in dog heart-lung preparation, and was more potent than nifedipine in the negative chronotropic effect. 5. Nilvadipine in intravenous doses of 1-32 micrograms/kg decreased total peripheral resistance and systemic blood pressure, and slightly increased cardiac output, pulmonary arterial blood flow and stroke volume, but had no significant effects on pulmonary vascular resistance or pulmonary arterial blood pressure. Heart rate decreased at doses of 32 micrograms/kg or more. Nifedipine had almost the same effects as nilvadipine on total peripheral resistance and blood pressure, but was more potent than nilvadipine in increasing effects on cardiac output, stroke volume and pulmonary arterial blood flow.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1988

[A case of bilateral adrenal non-Hodgkin lymphoma].

A 47-year-old woman presented with the chief complaint of gait disturbance and pain of bilateral lower limbs. She was diagnosed as having necrotizing myelitis because myelography was normal and incidentally bilateral adrenal tumor was recognized by ultrasonography and computed tomography. Left adrenalectomy was performed under the diagnosis of bilateral non-functioning adrenal tumor or metastasis to the adrenal glands with unknown origin. The tumor was 10 x 6 x 3 cm in size and 175 g in weight. The pathological diagnosis was non-Hodgkin lymphoma (diffuse large cell type). After combination chemotherapy of vincristine, cyclophosphamide, prednisolone and adriamycin, residual right adrenal mass showed a remarkable reduction, but unfortunately she died 5 months later postoperatively because of complications of lung edema and pneumonitis.

Adrenal Gland Neoplasms↗
PubMed1988

[A study on the correlation of histopathological findings with prognostic factors in maxillary antrum carcinoma].

Radiotherapy is usually employed as a part of a multidisciplinary treatment for squamous cell carcinoma of the maxillary antrum. In general, the clinical stage classification relates well with the prognosis. Sometimes, however, even early cases may have a poor prognosis if some other prognostic factors also are related. According to the histopathological findings of biopsy specimens of 74 patients, a grading on malignancy is discussed. Three different morphological parameters have been evaluated with respect to the tumor cell population in terms of the four-point scale. This has permitted a grading with total points ranging from 3-12. The correlation between the degree of histopathological malignancy and neck node metastasis has been found to be remarkable.

Carcinoma, Squamous Cell↗
PubMed1987

Phase II study of oral VP-16-213 in small cell lung cancer.

The soft, gelatin capsule of VP-16-213 (etoposide) was given orally and evaluated in a Phase II study of 56 patients with histologically confirmed small cell lung cancer. The drug was given in a dose of 200 mg/body/day orally for 5 consecutive days, and the courses were repeated every 3 to 4 weeks depending upon the individual patient recovery from myelosuppression. An overall objective response was obtained in 17 patients (30%), five previously treated (23%) and 12 untreated (35%). The median days for response after the start of treatment was 14 d (range, 5 to 64), and the median duration of response was 62 days (range, 28 to 278). The dose-limiting factor was leukopenia, while thrombocytopenia was also experienced. Gastrointestinal reactions to toxicity and alopecia were also observed, but they were not overwhelming. The study demonstrated that the VP-16-213 soft gelatin capsule given orally is effective against small cell lung cancer without clinical cross-resistance to other cytotoxic agents. Its usefulness in combination chemotherapy is thus suggested.

Administration, Oral↗
PubMed1987

Mitomycin C, vinblastine and cisplatin combination chemotherapy in the treatment of advanced non-small cell lung cancer.

Thirty-one patients with previously untreated advanced non-small cell lung cancer were treated with mitomycin C (10 mg/m2, day 1), vinblastine (5 mg/m2, days 1 and 15), and cisplatin (80 mg/m2, day 1). Combination chemotherapy was repeated at 4-week intervals until disease progression or unacceptable toxicity. The overall response rate was 52.0%, with a median survival time of 8 months. The median duration of response was 16 weeks (range, 7-49 weeks), and 23% of the patients survived for more than 1 year. Toxicity included moderate myelosuppression, mild nephropathy, and severe nausea and vomiting. This combination therapy of anticancer agents appears to have antitumor activity, but not to have satisfactory therapeutic activity for advanced non-small cell lung cancer.

Adenocarcinoma↗
PubMed1987

Binding of prolactin and monoclonal antibody to prolactin receptors immobilized on a nitrocellulose membrane filter.

Mammary prolaction (PRL) receptors in 3-[(3-cholamidopropyl)dimethylammonio]propanesulfonic acid (Chaps) extract were immobilized on a nitrocellulose (NC) filter, and a binding assay using the filter-bound receptors was carried out in the absence of detergent. PRL binding to the receptors was dependent on the quantity of the receptors and the PRL added to the filters. The filter-bound receptors retained the specificity of binding to peptide hormones. Scatchard analysis showed that the number of PRL receptors and the dissociation constant for PRL binding are essentially unchanged after immobilization on a NC filter, indicating that the PRL binding site does not participate in the binding to the NC filter and is equally available for PRL binding. The monoclonal antibody (MAb) against the PRL receptor was able to bind specifically to the Chaps-solubilized and filter-bound PRL receptors, as shown by curvilinear Scatchard plots. Immobilization on NC filters permits direct detection and characterization of the soluble PRL receptor using labeled PRL or MAb.

Animals↗
PubMed1987

Positional nystagmus of benign paroxysmal type (BPPN) due to cerebellar vermis lesions. Pseudo-BPPN.

Positioning nystagmus accompanied by severe vertigo had been reported in patients with partial lesions of the inner ear, especially otolith lesions. Typically this type of nystagmus represents a latent period and subsequent fatiguability. We concur with this finding and have constantly emphasized the significance of this phenomenon in clinical diagnosis. Since we started to use CT-scanning, this type of nystagmus has been noted in 20 patients, all of whom had cerebellar vermis lesions. Attention should be focused on this association. A simple coincidence could not be excluded if such a combination were seen in only 1 or 2 patients, it could be attributed to simple coincidence. But its occurrence in as many as 20 patients a causal role of cerebellar vermis lesions. Its mechanism may be explained by incomplete inhibition of the vestibulo-oculomotor system including the cerebellar flocculonodular lobe or vestiburo-cerebellum.

Arachnoid↗
PubMed1987

Origin of the initial negative potential (N15) recorded on the skull by superficial radial nerve stimulation in the cat.

The origin of the initial prominent negative potential with a latency of about 15 msec (N15), recorded on the skull by superficial radial nerve stimulation was studied in the cat, and the following results were obtained. In the direct recording from the cortex, SEPs were elicited from the SI and SII areas, as well as the lateral gyrus and anterior suprasylvian gyrus. Among various wave forms recognized in the SI area, diphasic positive-negative (P-N) potential obtained from the postero-lateral part was most distinct, representing the primary evoked potential. Responses recorded on the dura and those directly on the cortex showed similar wave patterns over many sites. Although different forms of evoked potentials were recorded extensively over the skull, the most prominent negative potential was elicited at the site corresponding to the postero-lateral part of the SI area. The latency of this potential was approximately in agreement with that of the negative component of the P-N potential recorded on the cortex. Based on the intracortical laminar analysis of P-N potential, the positive component of this potential was assumed to reflect the activity of cells in the deeper layer of the cortex. The negative component, on the other hand, might represent activities of apical dendrites of the cortex. From the result of functional elimination of the cortex, however, this positive component was thought to contain potentials from far field neural structures. N15 recorded on the skull completely disappeared during cortical spreading depression.(ABSTRACT TRUNCATED AT 250 WORDS)

Afferent Pathways↗
PubMed1987

Origin of short latency somatosensory evoked potential in cats: especially potentials derived from thalamus and cortex.

Short latency somatosensory evoked potential (SSEP) was recorded in cats to identify the potentials originating from the cortex and the thalamus, and the following results were obtained. When SSEP was elicited on the bregma by stimulation of the contralateral superficial radial nerve, P2, P4, P4.5, P5.5, P7, P8, N8.5, P11, P9.5, N11.5, N12.5 and N14 were recognized. Of these components N11.5, N12.5 and N14 consisted of large negative potential (LNP). When KCl was applied to the sensorimotor cortex to induce spreading depression, the positive component of the primary evoked potential was markedly decreased and the negative component disappeared. In SSEP, components preceding N8.5 were unchanged. N8.5-P11 and P11-N12.5, however, markedly diminished or disappeared. The latency of the first component of the field potential recorded in the VPL nucleus of the thalamus was about 5 ms. When a small amount of Nembutal was injected into VPL nucleus, components between P2 and P4.5 remained unchanged, but P5.5 disappeared. P7, P8 and N8.5 were preserved. The amplitude of N8.5-P11 was markedly decreased and LNP disappeared. From these results, among various components of SSEP, P5.5 should originate from the thalamus, and P7, P8 and N8.5 from the extralemniscal system. N8.5-P11 should mainly represent post-synaptic potential (PSP) in the deep somatic layer, and P11-N12.5 represent PSP in the apical dentrites of the sensorimotor cortex. N14 probably represents PSP via the diffuse projection system. Thus, LNP should consist of complex potentials of specific and non-specific sensory systems.

Animals↗
PubMed1987

Modulation of the transferred mouse 26K casein gene in mouse L cells by glucocorticoid hormone.

The cloned 26K casein gene was transferred to mouse L-cells and its expression was measured by Northern blot hybridization. When the lambda clone with 5'- and 3'-flanking sequences was transferred, transcripts were detected without glucocorticoid, but in the presence of glucocorticoid, the level of the transcripts of heterogeneous sizes increased and their pattern was similar to that observed in the mammary glands of non-lactating mice. When the 6.7 kb EcoRI fragment containing most of the coding region was transferred, putative precursor and mature mRNAs were detected without glucocorticoid. Surprisingly, with the addition of glucocorticoid, the level of the transcripts greatly decreased. The presence of multiple sequences responsible for glucocorticoid receptor binding was detected in the 5'-flanking region of the gene in a competition assay using the subfragments of casein gene and on sequence analysis. These results suggest that the 26K casein gene has multiple regulatory domains which interact with glucocorticoid receptors, and these domains may play different roles in the regulation of the casein gene.

Animals↗