Squamous metaplasia in fibroadenomas of the breast.
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Adenofibroma↗
Biomedical subjects
S Shousha
Publications and source records attributed to S Shousha.
Alveolar variant of invasive lobular carcinoma of the breast: an electron microscopic study.
Four cases of alveolar variant of invasive lobular carcinoma of the breast were examined by electron microscopy, and their appearance compared with those of in situ and classical invasive lobular carcinoma. The individual tumor cells in the alveolar variant were basically similar to those described in the other two lobular tumors. The neoplastic alveoli consisted mostly of light cells, although a few dark cells were sometimes seen at the periphery. The nuclei were large, rounded and rich in euchromatin. The cytoplasm contained a variable amount of mitochondria and endoplasmic reticulum, and a few cells had intracytoplasmic filaments. Numerous tumor cells with membrane-bound electron-dense granules were occasionally seen. A few cells also had intracytoplasmic lumina. Tumor cells were usually seen in close contact with each other. Interdigitating processes and desmosomes were present. In general the tumor cells were not surrounded by basal lamina, but most alveoli were surrounded by elongated fibroblasts or myofibroblasts. These findings confirm both the lobular and the invasive nature of this distinct variant of breast carcinoma.
Aged↗
Ferritin and lysozyme distribution in normal and abnormal duodenal mucosae.
The distribution of ferritin and lysozyme in 19 normal and abnormal duodenal biopsies was studied by an immunoperoxidase technique. The abnormal biopsies included cases of chronic duodenitis with gastric metaplasia, gastric heterotopia, villous atrophy, and a case of hemochromatosis. Ferritin is demonstrated in duodenal absorptive cells, with the staining being most intense in the hemochromatosis case. It was absent in duodenal cells showing gastric metaplasia and in the surface epithelial cells of most biopsies with villous atrophy and gastric heterotopia. Lysozyme-positive mononuclear inflammatory cells were markedly increased in all abnormal biopsies. Not all lysozyme-positive cells were ferritin positive. The latter were especially abundant in areas with gastric metaplasia. It is suggested that this abundance may be related to passive diffusion of intestinal contents, particularly iron, through the metaplastic areas, and consequently there may be a relationship between the presence of duodenal gastric metaplasia and uncontrolled iron absorption.
Atrophy↗
Secondary amyloidosis of the gastrointestinal tract: an electron microscopic study.
Biopsy specimens of the gastric antrum, duodenum, and rectum from three patients with secondary amyloidosis were examined by electron microscopy in an attempt to determine the ultrastructural distribution of amyloid filaments and to identify any secondary changes in the covering mucosal epithelial cells. The characteristic amyloid filaments were seen in the walls of submucosal arterioles and mucosal capillaries deposited within the basal lamina surrounding the endothelial cells. Filaments were also sometimes seen within the muscularis mucosa. the overlying gastric and rectal epithelial cells appeared normal, but numerous curved bacilli were seen in close contact with the microvilli of the surface epithelial gastric cells. Duodenal columnar absorptive cells were vacuolated and contained prominent lysosomes. These changes are probably degenerative and may explain, at least in part, the development of malabsorption in some patients with intestinal amyloidosis.
Adult↗
Recurrent bleeding from idiopathic ulceration of small bowel.
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Aged↗
A study of incidence and relationship of intestinal metaplasia of gastric antrum and gastric metaplasia of duodenum in patients with nonulcer dyspepsia.
The incidence and relationship of intestinal metaplasia of the gastric antrum and gastric metaplasia of the first part of the duodenum were studied in endoscopic biopsies from 120 patients with nonulcer dyspepsia. Intestinal metaplasia was present in 29% of antral biopsies and gastric metaplasia in 39% of duodenal biopsies, with 9% of patients having both. Intestinal metaplasia was not related to alcohol consumption, but was significantly higher in patients who smoked 10 cigarettes or more daily. (P less than 0.002). Gastric metaplasia was associated with duodenitis. Its incidence was significantly higher in males (P less than 0.001) and in patients with a history of high/moderate alcohol intake (P less than 0.02); these findings are reminiscent of the presence of a similar relationship between these factors and duodenal ulcers and support the suggestion that duodenitis and duodenal ulcers probably represent different parts of a single disease spectrum. The presence of both types of metaplasia in 9% of the patients suggest that factors other than gastric acidity may influence the development of metaplasia.
Alcohol Drinking↗
A histochemical and immunohistological study of a testicular malignant teratoma containing embryonic and extraembryonic elements in various stages of development.
A testicular malignant teratoma containing embryoid bodies and other embryonic and extra-embryonic structures in various stages of development has been examined by several histochemical and immunohistological techniques to study the distribution of various substances in the teratomatous elements. The substances demonstrated included various types of mucins; argyrophil, argentaffin, Paneth cells and haemosiderin granules; alpha-fetoprotein, alpha-l-anti-trypsin, lysozyme, beta-HCG and CEA. The significance of the findings is discussed in relation to early embryonic development.
Adult↗
Squamous cell carcinoma of the breast.
We saw two cases of pure squamous cell carcinoma of the breast, one of which is associated with dermatomyositis. Electron microscopy of appropriately fixed tissue obtained from one tumor confirmed the squamous nature of the polyhedral and spindle-shaped tumor cells. One tumor was assayed for estrogen and progesterone receptor proteins and was found to be lacking both. Test results for mucin and carcinoembryonic antigen (CEA) were negative in both tumors. In contrast, a similarly examined case of invasive ductal carcinoma with areas of squamous metaplasia had slightly elevated concentrations of estrogen and progesterone receptor proteins, and test results for mucin and CEA were positive.
Adult↗
Orcein staining of leukocytes.
An Orcein staining method has been developed which stains mature and immature leukocytes in blood films and bone-marrow smears. Two different patterns of staining are obtained depending upon whether staining is or is not preceded by oxidation. In the latter case, all granulocytes and some monocytes show granular reddish-brown cytoplasmic staining. When prior oxidation is used, the staining is in the form of fine grey or black cytoplasmic granules. All lymphocytes, by both techniques, are negative. It is suggested that Orcein stains sulphated mucosubstances, possibly chondroitin sulphate, which in granulocytes is concentrated in their primary granules.
Chondroitin↗
The endoscopically abnormal duodenum in patients with dyspepsia: biopsy findings in 60 cases.
Biopsies from 60 patients with dyspepsia and endoscopically abnormal first part of duodenum were examined. The main endoscopic findings were duodenitis (35 cases), chronic ulceration (eight) and abnormal mucosal patterns (17). The latter included mucosal atrophy, thickening, irregularity, nodularity and polypoid formation. The main histological findings were duodenitis (40), gastric metaplasia (42) and gastric heterotopia (seven). The first two were commonly seen together. Heterotopia was not associated with inflammation. Good correlation existed between endoscopic and histological findings.
Adult↗
Chronic duodenitis with gastric metaplasia: electron microscopic study including comparison with normal.
Duodenal biopsies from 11 patients with non-ulcer dyspepsia were examined by electron microscopy. Chronic duodenitis with gastric metaplasia was seen in samples from four patients, and areas of normal-looking duodenal mucosa were present in nine. The metaplastic cells were similar to those previously described in association with duodenal ulcers. They usually showed marked morphological differences from the normal duodenal absorptive cells. The microvilli were distorted and reduced in number, the glycocalyx was ill-defined, the cytoplasm filled with mucous globules and the intercellular spaces, in some areas, were widened and contained acute and chronic inflammatory cells.
Adolescent↗
Heterotopic gastric tissue in the duodenum: a report of eight cases.
Eight patients with intraduodenal gastric heterotopic are described. Seven were under investigation for x-ray-negative dyspepsia, and one presented with repeated attacks of hematemesis. As all of these cases were diagnosed by the use of upper-gastrointestinal endoscopy and biopsy under direct vision, it is likely that more widespread use of these techniques will lead to an increase in the reported incidence of a condition previously thought to be rare.
Aged↗
Signet-ring cell adenocarcinoma of rectum: a histological, histochemical and electron microscopic study.
A signet-ring cell adenocarcinoma of rectum removed from a 71-year-old woman was examined by light and electron microscopy. Most of the mucin in the signet-ring cells was of the neutral type, although acidic, mostly non-sulphated, mucin was also present. Three other types of neoplastic cells. The similarities between this tumour and tumours described in the stomach, appendix and breast care discussed.
Adenocarcinoma, Mucinous↗
Immunohistological study of human lungs by immunoperoxidase technique.
An unlabelled antibody peroxidase-antiperoxidase method for the detection of IgG, IgM, complement (C3 and Clq), fibrinogen and albumin was applied to routinely processed paraffin sections of lung from 27 cases. The results in 11 cases were compared with those obtained by immunofluorescence using frozen sections. Tissue was obtained from surgical specimens of cases with interstitial pneumonia comprising 10 of the usual type (UIP) and three of the desquamative type (DIP). Tissue was also obtained from the specimens of cases with sarcoidosis (two cases) and granulomatous inflammation of unknown cause (one case). There were 11 control cases, nine with primary carcinoma of the lung and two with metastatic tumours of the lung. Immunoglobulins of various types and complement were seen in diseased lung tissue. Although most of these deposits were probably due to a non-immunological mechanism there was evidence of the possible implication of immune complexes in three cases of UIP and in the interstitial pneumonia present in the two cases of sarcoidosis. The immunoperoxidase technique is a more sensitive method than immunofluorescence and has the additional advantage of the easy identification of the precise sites of the various deposits.
Adult↗
Colonic ganglioneuroma. Report of a case in a patient with neurofibromatosis, multiple colonic adenomas and adenocarcinoma.
A 73 year old woman with cutaneous neurofibromatosis developed colonic carcinoma. The resected colon also contained multiple tubular adenomas and a polypoid ganglioneuroma. Multiple neurofibromas were seen during the operation over the serosal surface of the small intestine. Other cases of colonic ganglioneuromas and of combined neurogenic and epithelial colonic tumours are reviewed.
Adenocarcinoma↗
Orcein as a mucin stain for gastrointestinal tissue sections.
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Digestive System↗
Failure to demonstrate specificity of the morphological and histochemical changes in mucosa adjacent to colonic carcinoma (transitional mucosa)
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Adenocarcinoma↗
Bile duct carcinoma: a late complication of congenital hepatic fibrosis. Case report and review of literature.
Bile duct carcinoma is reported in a 50-year old man as a rare late presentation of congenital hepatic fibrosis (CHF). A survey of the world literature suggests that carcinoma occurs with increased frequency in congenital biliary dilatation. It appears to be a particular risk in patients with prolonged survival but is rare in CHF, where portal hypertension and renal insufficiency make the long-term prognosis poor. In this patient the absence of both gastroesophageal varices and renal disease may have permitted longevity with development of carcinoma. The finding of carcinoma arising in the bile ducts distal to the basic lesion of CHF suggests that active carcinogens may be present in the bile in CHF. The tumor in this patient was unusual in producing mucinous biliary obstruction and terminal hypercalcemia.
Adenocarcinoma, Mucinous↗