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Biomedical subjects

S Stoĭkov

Publications and source records attributed to S Stoĭkov.

At least 19 recordsLinked to original sources
PubMed2006

[Multiple sclerosis and pregnancy (two additional cases)].

The authors made a short analysis of the epidemiology, etiology, pathogenesis, clinical presentation and treatment of multiple sclerosis. There were presented facts about the influence of pregnancy over the progress of this neurological disease, and the effect of multiple sclerosis on the pregnancy and delivery development. There also were described two clinical cases of pregnant women with multiple sclerosis, who delivered in the last 10 years in Clinic of Obstetrics in MBAL-Pleven.

Adult↗
PubMed2006

[Terminated pregnancy following prenatal diagnosis of congenital anomalies--a part of register of congenital anomalies].

UNLABELLED: The most of European registries of congenital anomalies (CA) collected information of CA in livebirths, stillbirths and terminated pregnancies following prenatal/ultrasound diagnosis. OBJECTIVES: to assess terminated pregnancies after prenatal/ ultrasound diagnosis of CA as a part of register of CA performed in University Hospital-Pleven. Among 21 202 births monitored during the study period (1996-2005), 679 CA were detected. The total prevalence of CA was 32/ 1000 births. The outcome of pregnancy for all cases of selected CA by register was 620 livebirths (91.3%), 36 stillbirths (5.3%), 23 terminated pregnancies (TP) (3.4%). The percentage of pregnancy termination was higher in the case of isolated anomalies, mainly lethal and CA associated with a low survival rate (61%), than with multiple ones. The most common CA detected after prenatal/ ultrasound diagnosis were neural tube defects (NTD) - the main reason for TP (52% of cases). The low proportion of these CA in TP (1/3) compared to their proportion in livebirths (50%) demonstrated an insufficiency of prenatal diagnosis of NTD as a part of register of CA performed in University Hospital-Pleven. Prenatal diagnosis of CA allows an early genetic counseling of mother presenting information on neonatal prognosis and recurrence risk for subsequent pregnancies. It helps family to take an adequate decision for termination of pregnancy with bad prognosis about heavy fetal CA.

Abortion, Induced↗
PubMed2006

[An evolution in the conduct for ectopic pregnancy in gynecological clinic, "UMBAL - D-r G. Stranski", Pleven for 7 years' period].

AIM: The aim of the present study is to show the evolution of the conduct for ectopic pregnancy for 7 years' period after introduction in gynecological practice of contemporary diagnostic and therapeutic methods for ectopic pregnancy. For the fulfillment of this aim was made a prospective study for 7 years' period of the patients with diagnosis "Ectopic pregnancy", treated in Gynecological clinic of "UMBAL - D-r G. Stranski" EAD, Pleven. MATERIALS AND METHODS: The objects of observation were 198 women with diagnosis: "Ectopic pregnancy". There were used the following methods: clinical, technical devices, statistical methods. RESULTS: The authors analyze the results of the use of laparoscopy, conventional surgery and application of Methotrexate describing the indications and the risk for the patient. CONCLUSION: The authors emphasized the advantages of the gynecological laparoscopy for precise diagnosis and contemporary treatment of the intact ectopic pregnancy.

Abortifacient Agents, Nonsteroidal↗
PubMed2006

[A rare case of ovarian carcinosarcoma with metastasis in the uterine cervix--diagnostic and therapeutic problems].

Carcinosarcomas are rare malignant neoplasms that histologically contain both epithelial and mesenchymal components. In the female genital tract they occur mainly in uterus and rarely in cervix, ovaries and omentum. A rare case of ovarian carcinosarcoma is presented. Because of the presence of a solitary, massive metastasis in the uterine cervix, it created some serious diagnostic and therapeutic problems.

Aged↗
PubMed2006

[Usage of the new parenteral selective cox-2 inhibitor dynastat in the gynecologic practice].

A follow-up of 180 women was carried out. The patients having endured different gynecological operations (laparoscopy, laparohysterectomy, etc.) were divided into two main groups: half of them were treated with Dynastat (new selective COX-2 inhibitor) and the others were treated with Profenid (conventional nonsteroidal anti-inflammatory drug). The groups were compared by the quality of the achieved analgesia and appeared side effects, especially postoperative nausea and vomiting. These parameters were assessed by both medics and patients. In conclusion we accept that the new COX-2 selective inhibitor Dynastat does not have advantages over traditional nonsteroidal anti-inflammatory drug as Profenid especially for postoperative nausea and vomiting and quality of analgesia.

Adolescent↗
PubMed2005

[Gynecological laparscopy, endometriosis and sterility].

The authors presented the importance of the gynecological laparoscopy for diagnosis of the external genital endometriosis in its different forms. In the last 20 years, it was seen that laparoscopy is not only the basic method for diagnostics but also for the surgical treatment of the endometriosis. Thirty to fifty percent of the females with endometriosis in reproductive age have available sterility. The authors presented the cases, which have been laparoscopically proven for endometriosis and sterility for 7 years' period in Gynecological clinic in MBAL-Pleven and the results from the treatment with analog of the Gonadoliberins (Zoladex).

Bulgaria↗
PubMed2005

[Results of diagnostic hysteroscopy in a 7-year period in the gynecological clinic of "UMBAL-Pleven"].

The aim of the authors is to show the data for the reception diagnosis, age, histological results and the conduct after the performed diagnostic hysteroscopies in Gynecological clinic of UMBAL-Pleven. For the fulfillment of this aim was made a prospective study for 7 years' period: from 01/01/1997 to 31/01/2003. The objects of observation were 74 women of age from 16 to 65 years, with performed hysteroscopies for gynecologic complaints. There were performed 74 diagnostic hysteroscopies for the studied period. The hysteroscopic findings were 20 cases with endometrial polyposis, 14--submucosal myoamatic nodes, deforming the uterine cavity, 4--cervical polyp, 19--increased endometrium, 9--Asherman syndrome, 1--bicomous uterus, 1--a suspected section for endometrial carcinoma and 6 cases without pathologic findings. There were performed 59 trial abrasions and the removed materials were sent for histological examination The performed comparative analysis between the hysteroscopic presentation and histological findings showed a coincidence of the diagnosis. It was made the conclusion, that the hysteroscopy is an easy, accessible and inexpensive diagnostic method, which must take its place as one of the basic contemporary diagnostic methods in gynecology.

Adolescent↗
PubMed2005

[Gynecological laparoscopy and treatment of ectopic pregnancy].

The aim of the present study is to show the advantages of the gynecologic laparoscopy for the diagnosis and treatment of the intact tubal pregnancy. For the fulfillment of this aim was made a prospective study for 5 years' period of the patients with diagnosis "Ectopic pregnancy", treated in Gynecological clinic of UMBAL-Pleven. The objects of observation were 33 women with diagnosis: "Intact ectopic pregnancy". Methotrexate was used by plan for 6 patients, in 7 patients was made laparotomy, and in 20 patients--gynecological laparoscopy. From the performed 20 gynecological laparoscopy, 16 women were recovered laparoscopically, in 14 of which was made partial salpingectomy, and in 2--milking. In one of the last two patients was injected Methotrexate in the bed of the gestational bag. In 4 women was necessary laparotomy, because of impossibility of performing of laparoscopic surgery. The authors emphasized the advantages of the gynecological laparoscopy for precise diagnosis and contemporary treatment of the intact ectopic pregnancy.

Antimetabolites, Antineoplastic↗
PubMed2005

[Correlation between receptive wall analysis of benign ovarial cysts and their clinical conduct].

UNLABELLED: The biological behaviour (conduct) of benign ovarial cysts is interesting due to their comparatively high frequency of appearance and clinical manifestation. (During the last five years their frequency is between 62%-65% of the gynaecological surgical interventions). With this current survey the authors try to set up a target for research study of the wall receptive status of benign ovarial cysts. This study should be treated as a start up point rendering a prognosis for their eventual biological development. MATERIALS AND METHODS: An immunohistochemical survey was carried on with 50 patients who have already reached the surgical treatment in retrospective order for the period 2001-2003 (three years' period). The survey search is in direction receptive analysis of Estrogene /E2/ and Progesterone /P/ wall receptor in the ovarial cyst. A perspective observation was also carried on (control group of 50 cases) of hormonal-gestagene treatment of the benign ovarial cystogenesis. It appears to be the necessary prove material for hormonal receptors' participation in the cyst wall as an active factor for its development and involution. RESULTS: In the basic group /surgical treatment/ it was stated: In 39 patients--E2/-/, P/-/; in 4 patients--E2/+/, P/+/ In 5 patients--E2/+/, P/-/; in 2 patients--E2/-/, P/+/ CONCLUSION: The executed retrospective analysis demonstrates statistical importance in receptor competency lack in the wall of benign ovarial cysts as the probable grounds for them not being influenced during the conservative treatment method. This method led to the surgical elimination of the cyst. The statistical reliability, connected with the receptor E2 participation in the therapeutic behaviour of the benign ovarial cysts, is not stated. The final conclusions acquired from the executed research work would be a discussion issue after the correlative aspects in the prospective group are surveyed. The benign ovarial cysts' hormonal profile would be taken into consideration also.

Female↗
PubMed2005

[Microglandular endocervical hyperplasia and endocervical adenocacinoma in pregnant--description of two cases].

Two clinically identical cases of young, pregnant women, presented with exocervical polypoid masses are described. Because of beginning delivery in both cases, the diagnoses are made on frozen sections. In the first case histological examination reveals microglandular endocervical hyperplasia. A successful delivery by caesarian section and no more operations is performed. In the second case, an endocervical adenocarcinoma is diagnosed and after a successful delivery by caesarian section, a laparohysterectomy with bilateral adnexectomy and lymph node dissection is performed. Detailed histological examination of the endocervical neoplasm discloses a well differentiated papillary villoglandular adenocarcinoma, containing minor elements of more aggressive serous carcinoma, which may adversely affect the outcome. Three consequent recurrences are found in this patient for a period of 5 years and 3 months after the operation.

Adenocarcinoma↗
PubMed2005

[Progress in methods of therapeutical abortions during the second trimester in gynecological clinic "Umbal - Pleven"].

The aim of the authors is to discover the progress in the methodology for the interruption of pregnancy by medical indications during the second trimester in Gynecological clinic in UMBAL - Pleven. A retrospective study has been performed for the used methods in the last 10 years. For the same period were performed abortions in 49 women by medical indications. The interruption of pregnancy until the 16th gestational week (g.w.) of gestation was performed in one-stage. From the 16th g.w. to the 20th g.w., the most common method till the year 2001 was intraamniotic instillation of 25% solution of NaCl by Aburel (1934). After the 20th g.w. the pregnancy was interrupted either by metrierasis (using balloon catheter), or by sectio parva. After the 2001 was described radical change in conduct by therapeutic abortion during the second trimester, after the beginning of the prostaglandins use in obstetrical practice. The authors analyze the results of the use of prostaglandins describing the type, dosage of used medicine, period of abortion, contraindications and the risk for the mother. They reach to the conclusion that the prostaglandins are presently suitable means for therapeutical abortion during the second trimester, which fully replace the classical, traumatically and risky methods for the pregnant woman.

Abortifacient Agents↗
PubMed2005

[Treatment of tubal pregnancy with methotrexate in gynecological clinic of MBAL-Pleven during five year period].

The authors presented a short survey for application of Methotrexate for treatment of intact ectopic pregnancy and its usage in Gynecological clinic of MBAL-Pleven during the last five years. There was made a prospective study, and for the studied five years' period in the clinic there were treated 149 women with ectopic pregnancy, 33 of which were hospitalized with intact tubal pregnancy. Methotrexate was used by plan for 6 patients as for 3 of them the treatment was successful. The authors also described two of these cases according to the diagnosis, way and usage period of the cytostatic and the result from the disorder. In conclusion there was emphasized that the treatment of intact tubal pregnancy with Methotrexate has a place in gynecological practice in view of the fact that it decreased physical pain, psycho-emotional stress and bed staying of the patient, but the cases must be strongly selected.

Abortifacient Agents, Nonsteroidal↗
PubMed2005

[Use of low molecular weight heparin (Clexane) together with selective COX-2 inhibitor (Dynastat--once or twice per day)].

A follow-up of forty women was carried out. The patients having endured a gynecological operation (laparohysterectomy) were divided into two groups: group A--treated with Dynastat (40 mg/24h) and group B--treated with Dynastat (80mg/24h) which was combined in both groups with Clexane. The hematological and hemostatic parameters were evaluated during the early postoperative period--the first 24 hours. The women were followed until they were discharged from hospital. No significant changes of these laboratory parameters were noticed and the clinical stability of the patients in both groups was unaffected. The results showed that Dynastat/Clexane combination could be applied in the clinical practice as it proved great extend of safety for usage after gynecological operations.

Anticoagulants↗
PubMed2004

[Active screening for genetic pathology in newborns. I. Registration of congenital abnormalities].

Active screening for genetic pathology over a period of 12 years (1990-2001) involved examination of 29,629 newborns at the Clinic of Obstetrics and Gynaecology. Congenital anomalies were detected in 1244 cases (live-, stillbirths and terminated pregnancies) which gives an average incidence rate of 42.0 per 1000 among the studied population. Congenital cardiac anomalies and CA of the central nervous system were the most common types of isolated CA. They provided frequencies of 7.76 per 1000 and 6.85 per 1000 cases respectively. The incidence of the neural tube defects (NTD), particularly, varied throughout the years (t = 2.69; p < 0.01) but stated high--on average 2.12 per 1000 with the highest rate of 3.89 per 1000 in 1993. A reduction in the incidence of NTD is possible with a recommendation of periconceptional folic acid supplementation. Registration of CA is a strategy for identifying families at risk to give births of child with CA. This approach enabled us to provide more accurate genetic counselling and prenatal diagnosis for genetic pathology. Active screening of newborn population is likely to be an effective and necessary service.

Bulgaria↗
PubMed2004

[Gynecological laparoscopy and Mayer-Rokitansky-Kuster-Hauser syndrome (report of three cases)].

The syndrome is described in 1838 and it is named after the four authors. It includes combined agenesis of uterus, cervix and the upper 2/3 of the vagina, but the fallopiantubes and ovaries are normally presented. Expect abnormalities of the female reproductive system there are abnormality of the kidneys, vertebral bodies and loss of hearing. The authors of the present publication describe in details etiology, pathogenesis, clinical presentation, differential diagnosis and therapeutic methods for syndrome's treatment. There are presented three clinical cases, which are by laparoscopy proved. In conclusion it is indicated the importance of the gynecological laparoscopy like a modern method for diagnosis of the congenital anomalies of the female genital tract leading to primary amenorrhea.

Abnormalities, Multiple↗