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Biomedical subjects

S Sulkowski

Publications and source records attributed to S Sulkowski.

At least 127 records · Page 7Linked to original sources

[Morphological changes of bone marrow in patients with bronchial and gastrointestinal carcinoma and hematological abnormalities in peripheral blood].

The authors carried out the morphological and clinical analysis of 200 cases patients suffering from carcinoma but not treated (104 cases of carcinoma of the bronchus, 30 cases of the stomach, 26 cases of the pancreas, 24 cases of the liver and gallbladder and 16 cases of the large intestine) and have estimated the hematological and bone marrow abnormalities. Most frequently occurring hematological changes in this group were: anaemia (28.5%), thrombocytopenia (22.4%), clinical symptoms of thrombosis (22.0%) and changes of bone marrow: sclerosis (42.5%), neoplastic metastases (30.0%), and atrophy (27.5%). In the examined cases the authors have not found any particular connection between the kind of hematological abnormalities and the kind of morphological changes of the bone marrow. The most common changes in the bone marrow which accompanied hematological abnormalities were neoplastic metastases and atrophy of the marrow especially in cases with anaemia and thrombocytopenia.

Adult↗

[Atrophy of the bone marrow].

The authors made a quantitative analysis of the active hematopoietic tissue of the bone marrow with particular consideration of its atrophy in the course of various diseases. The material consisted of 407 non-selected autopsy cases. For a morphometric analysis the bone marrow was sampled from the sternum, ala ossis illi and spine. In the quantitative analysis of the active hematopoietic tissue we took into account age groups as quantitative changes appear with age. Atrophy of the bone marrow was in 19.4% of the studied cases. The presence of bone marrow atrophy was found in the course of various diseases, most frequently neoplastic, particularly in patients aged from 50 to 59 years.

Adolescent↗

[Biliary atresia in children].

Congenital biliary tract atresia was found in 0.58% of children dying in the first year of life. Most frequently atresia included the extrahepatic bile ducts, among them the common bile duct. Five cases (35.7%) had atresia associated with other developmental anomalies, which may suggest a genetic determination of the atresia. The most frequent cause of death of the newborns and infants with congenital biliary tract atresia was bronchopneumonia with associated biliary cirrhosis of the liver.

Bile Ducts↗

[Congenital anomalies of the central nervous system in autopsy specimens].

On the basis of an analysis of 2398 autopsies of infants aged up to 1 year in 194 cases congenital anomalies of the central nervous system were found (8.1%). Most cases of these anomalies were noted in the group of newborns (85%) and the most frequent anomalies were: myelomeningocele (35.6%), multiple anomalies (20.1%), congenital hydrocephalus (17%), anencephaly (14.4%) and corpus callosum malformations (3.6%). Myelomeningocele, congenital hydrocephalus, anencephaly and true microcephaly were more frequent in girls, while multiple anomalies and corpus callosum malformations were more frequent in boys.

Abnormalities, Multiple↗

[Analysis of neoplasm metastases to the bone marrow in patients with lung cancer].

The authors analysed bone marrow metastases in lung cancer in 104 deceased patients. Trepano-biopsy was taken from the sternum, hip bone and spine. Bone marrow metastases were found in 33 cases (31.73%). Most often they were seen in small cell lung cancer (16 cases--35.56%). In 12 cases the bone marrow was the only site of lung cancer metastases.

Adult↗

[Primary sarcoma of the lung].

The authors present two cases of rare primary lung neoplasms smooth cell sarcoma and fibrosarcoma. Diagnostical dilemmas are discussed.

Adult↗

[Sclerosis and fibrosis of the bone marrow in lung and gastrointestinal tract cancers].

The authors analyzed the incidence of pathologic lesions of the bone marrow in the form of sclerosis and fibrosis in patients with lung and gastrointestinal tract (gastric, pancreatic, hepatic and bile duct) carcinomas. In the analysis of argentaffin and collagen fibres in the bone marrow we used Kundel's score modified by Bauermeister. The results obtained in the studied group were compared with the bone marrow of persons without neoplastic diseases and other disorders that might have affected the bone marrow. It was found that in patients with neoplastic disease and fibrosis of the bone marrow were quite frequent disturbances.

Aged↗

[Pulmonary bone marrow embolism in nonselected autopsy material].

We analyzed the incidence of bone marrow emboli of the pulmonary arteries in nonselected autopsy material involving 620 cases. We evaluated the incidence of these emboli, age, sex, underlying disease and microscopic picture. It was found that bone marrow emboli of the pulmonary arteries occurred in 7% of cases, most frequently in patients aged from 50 to 69 years and they were located in the medium and small-lumen arteries. It was found that bone marrow emboli of the pulmonary arteries may complicate posttraumatic bone fractures, costal and sternal fractures in the course of reanimation as well as malignant neoplasms and shock.

Adult↗

[Neoplastic metastases in the bone marrow from cancers of the digestive system (stomach, pancreas, liver and gallbladder].

The authors analyse the incidence of metastases into the bone marrow in carcinomas of the stomach, pancreas, liver and gallbladder. Specimens from the bone marrow taken were by trephine biopsy from the sternum, ala ossis ilii and spine. Metastases into the bone marrow were found in carcinomas of the stomach, pancreas and gallbladder but not in hepatic carcinoma. Neoplastic metastases were most frequent in adenocarcinoma of the stomach.

Adenocarcinoma↗

[Necrosis of the bone marrow].

The authors analyzed the incidence of necrosis of the bone marrow in nonselected autopsy material. The studies included 419 cases of various disease types. Necrosis of the bone marrow was found in 83 cases (19.8%). It was most frequently observed in patients with neoplastic disease of the hematopoietic and lymphatic systems (26.3%) and malignant neoplasms of different origin (21.9%). In 40% cases necrosis of the bone marrow were accompanied by neoplastic metastases into the hematopoietic tissue, and thrombotic changes in the blood vessels occurred in 22.9% of these cases. Our results point to a fairly frequent occurrence of necrosis of the bone marrow, especially in the course of neoplastic disease.

Bone Marrow↗

[Lymphocytic aggregations in the bone marrow: their occurrence and morphologic analysis].

We analyzed the morphology and incidence of aggregations of mature lymphocytes of the bone marrow in the autopsy material of 425 cases excluding disorders of the hematopoietic and lymphatic systems. We found that lymphocytic aggregations occurred in 21.1% cases. There were two morphologic types of lymphocytic aggregations of the bone marrow, namely lymphoid follicles and infiltrates. It was shown that the incidence of lymphoid nodules of the bone marrow increased with age and that the structures were more frequent in women. We pointed to the significance of lymphocytic aggregations presence in the bone marrow in differentiating with malignant infiltrations of the lymphatic system involving the bone marrow.

Adolescent↗

[A case of primary cardiac myosarcoma].

The case of the very rare, primary malignant neoplasm of a cardiac origin was presented. Authors discussed diagnostic difficulties and clinical symptoms of a disease.

Heart Neoplasms↗

[Primary malignant lymphomas of the digestive tract. Morphologic and clinical analysis of 100 cases].

The morphologic and clinical evaluation of malignant lymphomas having the primary localization in the digestive tract has been presented. The analysis of particular cases involved the localization of tumors, the histological types, age, sex and clinical symptoms. It has been stated that malignant lymphomas are rare primary malignancies of the digestive tract which develop most frequently in the stomach and their clinical course may be masked by other diseases of digestive tract.

Adult↗