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S Sulkowski

Publications and source records attributed to S Sulkowski.

At least 145 records · Page 8Linked to original sources
PubMed1987

Plasminogen activator activity in venous walls of patients who died of myocardial infarction.

The aim of this study was to compare the activity of the plasminogen activator in walls of various veins obtained from 29 patients who died of myocardial infarction in the first 24 h. The control group consisted of 12 dissected persons without thrombotic complications before death. The activity of the plasminogen activator was determined by using the chromogenic substrate S-2251 according to SHIMADA technique. The twofold higher plasminogen activator activity was found in vessels of patients who died of myocardial infarction in comparison with persons who died of other causes. A significant correlation between the plasminogen activator activities of veins obtained from different parts of the body was also stated.

Humans↗
PubMedDate not supplied

Expression of the insulin-like growth factor-I receptor in primary breast cancer and lymph node metastases: correlations with estrogen receptors alpha and beta.

Numerous laboratory studies and some epidemiological data have suggested the involvement of the insulin-like growth factor-I receptor (IGF-IR) in breast cancer development and progression. However, data on IGF-IR expression in human tissues, including breast cancer sections, are limited and often inconsistent. We therefore examined by immunohistochemistry the expression of IGF-IR in primary tumors and breast cancer metastases to lymph nodes, and correlated IGF-IR positivity with estrogen receptor (ER) status and selected clinicopathological features. We found that 1) IGF-IR was expressed in primary tumors as well as in lymph node metastases, but the expression in primary tumors was more frequent (56 % vs. 44.4 %); 2) IGF-IR expression in primary tumors was associated with negative node status (p < 0.033); 3) in node-negative primary tumors, IGF-IR positively correlated with ERbeta (p < 0.008; r = 0.538), but not with ERalpha, tumor size or grade; 4) both IGF-IR-positive and IGF-IR-negative primary tumors were found to produce IGF-IR-positive as well as IGF-IR-negative metastases; 5) in metastases, IGF-IR expression did not associate with ERalpha, ERbeta or any of the studied pathobiological markers. The results suggest that IGF-IR could become a viable pharmaceutical target in breast cancer therapy, but such therapy should be based on IGF-IR assessment in primary tumor and metastasis in each potential patient.

Breast Neoplasms↗
PubMedDate not supplied

Papillary Hürthle cell tumor of thyroid: report of a case with a cytomorphologic approach to diagnosis.

BACKGROUND: Hürthle cells are founded often in fine needle aspirates of the thyroid from nonneoplastic and neoplastic lesions. Papillary Hürthle cell tumors of the thyroid are composed of oxyphilic cells with a prominent papillary component. Papillary Hürthle cell carcinoma is a relatively uncommon type of thyroid carcinoma. CASE: A 42-year-old man had two asymptomatic nodules (2.5 and 3.5 cm) in the left lobe and one (2.5 cm) in the right lobe of the thyroid. Fine needle aspiration biopsy of the tumor in the left lobe showed large cells in monolayers and papillary clusters with moderate to abundant eosinophilic, granular cytoplasm with sharp borders, a granular nuclear enlargement with pleomorphism and single nucleoli. Histologic examination showed capsular invasion and infiltration of vessels. CONCLUSION: The cytologic appearance of papillary Hürthle cell carcinoma is not specific but can be suspected on fine needle aspiration.

Adenoma, Oxyphilic↗
PubMedDate not supplied

Bcl-2 expression in primary uveal melanoma.

AIMS: Uveal malignant melanoma is the most common intraocular tumor. The aim of this study was the analysis of bcl-2 oncoprotein expression in this tumor type. The melanomas were evaluated according to tumor location and patient age and sex. The relationship between bcl-2 expression and histological type, clinicopathologic stage and the presence of a set of predetermined morphological parameters was analyzed. METHODS: The study involved 39 patients with ocular melanomas treated with surgery alone between 1983 and 1997. Formalin-fixed, paraffin-embedded tissues were treated with anti-bcl-2 antibody (Dako No M0887). Immunolocalization of the bcl-2 oncoprotein was performed using the labeled streptavidin biotin (LSAB) method. bcl-2 expression in neoplastic cells was evaluated in a semiquantitative manner: lack of reactivity was defined as bcl-2 negative, reactivity present in less than 30% of cells as low bcl-2, and reactivity in more than 30% of cells as high bcl-2. The percentage of cells with a positive reaction was assessed independently by two pathologists, and the results were subjected to statistical analysis using Fischer's exact test. RESULTS AND CONCLUSION: No statistically significant correlation was found between the expression of bcl-2 oncoprotein and the clinicopathologic features analyzed. However, the high percentage of tumors with positive expression of this oncoprotein suggests that it plays a significant role in the biology of uveal melanoma.

Female↗
PubMedDate not supplied

Endogenous lipid pneumonia- and alveolar proteinosis-type changes in the vicinity of non-small cell lung cancer: histiopathologic, immunohistochemical, and ultrastructural evaluation.

Endogenous lipid pneumonia (ELP) and pulmonary alveolar proteinosis (AP) are the most common pathological conditions of lung tissue in which there is an increased accumulation of surfactant elements in pulmonary alveoli. This paper evaluates the morphology, morphogenesis, and pathogenesis of ELP- and AP-type changes in the immediate vicinity of non-small cell lung cancer (NSCLC). The analyses used lung tissue obtained from the vicinity of 56 NSCLC. ELP- or/and AP-type changes in histopathological studies were found in lung tissue surrounding 35 NSCLC. Ultrastructural analyses by transmission electronmicroscopy identified 15 cases with advanced ELP and confirmed the possibility of coexistence of ELP- and AP-type changes in the vicinity of NSCLC and the evolution of ELP into AP. Most cases analyzed showed morphological features characteristic of both AP and ELP, the intensity and degree of these changes being considerably differentiated. Type II pneumocytes, macrophages, and neutrophilic granulocytes play a significant part in the morphogenesis of ELP and AP.

Carcinoma, Non-Small-Cell Lung↗
PubMedDate not supplied

Ultrastructural changes in the trabecular meshwork of congenital glaucoma.

Trabeculectomy specimens from 10 patients with congenital glaucoma were studied by electron microscopy. In all cases proliferation of fibrous connective tissue was found from the inner wall of Schlemm's canal. Accumulation of collagen fibres, sometimes of varied thickness and irregular striation, and agglomerations of microfibrillar material with the structure of collagen microfibrils were observed. This material formed basement membrane-like structures and 'shaggy' or fingerprint-like patterns. The ultrastructural examination of the trabecular meshwork revealed no significant differences between the morphological picture of primary congenital glaucoma and that found in Axenfeld and Rieger anomalies. Ultrastructural pictures of glaucoma cases examined in the present study converged also with those of juvenile glaucoma cases reported in literature, which may indicate the existence of a pathogenic factor common to these forms of glaucoma.

Female↗