PubMed Health⌕ Search

Biomedical subjects

S Sulkowski

Publications and source records attributed to S Sulkowski.

156 records · Page 9Linked to original sources

[Endocardial fibroelastosis in children to one year of age].

Out of 2398 autopsies of newborns and infants performed between 1976 and 1985, thirty two cases of endocardial fibroelastosis were found, i.e. 10.6% of the congenital heart diseases in this age group. Endocardial fibroelastosis was most frequent (44%) in infants aged between 3 and 6 months. Seventeen cases of the disease were seen in male infants and 15 cases in female infants. Twenty cases of the endocardial fibroelastosis (62.5%) were of isolated character (primary) whereas 12 cases (37.5%) were of the secondary character associated with other heart abnormalities. Nine cases (about 28%) coexisted with congenital abnormalities of joint and bone system and respiratory tract. A morphologic analysis of the endocardial fibroelastosis with particular reference to its etiopathogenesis suggest its congenital origin or (and) an effect of infection on myocardium. It was also suggested that endocardial fibroelastosis may be a symptom of collagenic disease. About 70% of autopsied infants were hospitalized over 3 days what meant that the course of the disease was severe. Endocardial fibroelastosis was diagnosed clinically only in 6 cases (18.75%).

Endocardial Fibroelastosis↗

[Clinico-morphologic analysis of subacute sclerosing panencephalitis in patients up to the 19th year of life].

Deaths of patients with the subacute sclerosing panencephalitis were analysed in the non-selected autopsy material within 1976-1985. Fifteen cases of the disease, i.e. 0.12% of all autopsies and 3.8% of autopsies in the age group between 1 and 19 years, were noted. Fourteen cases of the subacute sclerosing panencephalitis were noted in the age group of 5-14 years. Mean age was 9.3 years. The disease was nearly three-fold more frequent in male patients. Time lapse between measles infection or antimeasles vaccination and hospitalization for the subacute sclerosing panencephalitis was 4.2 years for both sexes and was much lower for male patients--2.9 years. Morphological lesions characteristic for the subacute sclerosing panencephalitis were seen in the white matter and cortex of the brain in all examined patients. Lesions to the basal ganglia were noted in 9 cases, and additionally to the brain stem and vermiform lobe in 3 cases. The most frequent clinical symptoms accompanying the subacute sclerosing panencephalitis at the beginning of the hospitalization, other diseases and conformation of the clinical diagnosis with sectional findings are also discussed.

Adolescent↗

[Multifocal periventricular leukomalacia in children up to 1 year of life].

The authors present an analysis of the multifocal leucoencephalomalacia in children under 1 year of life based on the material obtained from 2.398 autopsies. It was found that 32 autopsied children suffered from this disease (1.33%). Twenty four of these children were premature. The disease was more frequent in the infants (23 cases) than in neonates (9 cases), and in boys (20 cases) than in girls (12 cases). Multifocal leucoenephalomalacia was manifested mainly as spastic infantile paralysis in the majority of the infants (14 cases). Morphological lesions to the brain most frequently embraced white substance adjacent to the cerebral ventricles (foci of leucoencephalomalacia of 1 cm in diameter) and cerebral vessels. Widening of the ventricular system of the brain was seen in 15 cases. Pathological reaction resulted from the brain anoxia and ischemia in perinatal period (20 cases) or septicaemia (12 cases) while predisposing factors included: prematurity, respiratory failure with hyaline membranes in the lungs and congenital abnormalities of the heart.

Female↗

[Malignant neoplasms in autopsy specimens and the magnesium level in the soil of the communities of Gródek and Tykocin].

Morphological and statistical analysis was done of deaths caused by neoplasms in the populations of the communities Gródek and Tykocin on the basis of autopsies carried out in the years 1982-1986. The content of magnesium was determined also in the arable layer of soil in these communities. The proportion of deaths from malignancies in the analysed autopsy material was nearly threefold higher in the Gródek community (27.67%) than in the Tykocin community (9.87%). The Gródek community had nearly twice as much (49%) sandy soils with low magnesium content as the Tykocin community (24%). The prevailing malignancies in the Gródek community were in males aged 51-60 years mainly in the digestive tract (61.3%) and respiratory system (22.3%). Histological structure was in most cases that adenocarcinoma and squamous cell carcinomas.

Adult↗

[Coexistence of polycystic kidney and other developmental defects. Analysis of autopsy specimens 1953-1985].

The cases of polycystic disease of kidney selected from 33 years postmortem data were presented. They were classified into 4 types (according to Osathanond, Potter and Heptinstall) and the results correlated with accompanying malformations. It has been established that type I of polycystic disease of kidney was mostly correlated with CNS, skull and spine abnormalities. Type II and III were coexisting with genitourinary and ++gastrointestinal system malformations. No type IV of the disease has been found.

Abnormalities, Multiple↗

[Biological properties of cytokines and their role in lung pathology].

In the past decade, cytokines came into focus as important multifunctional mediators regulating cellular functioning and intercellular connections. Particular cytokines may both inhibit and stimulate cells playing an important role in maintaining homeostasis of the normal tissue. In the majority of pathologies not individual cytokines but their complexes are involved. Numerous studies on cytokines are mainly aimed at evaluating the role of the following cytokines in pulmonary diseases: tumour necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta), insulin-like growth factor I (IGF-I), interleukin-1 (IL-1), and recently interleukin-6 (IL-6). The possible physiologic significance and role of cytokines in lung diseases are surveyed.

Animals↗