The authors studied the plasma level of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E) and progesterone (P) in 2 female patients with chronic renal insufficiency (ChRI), aged 21--42, without any genital ailments. The patients were conservatively treated. The authors found elevated plasma level of FSH and LH in the plasma of the female patients with ChRI and decreased E and P. The direct lesion of the hypophyseal-ovarial axis by uremic toxins is the reason, admitted by the authors for the hormonal dysbalance in the patients with ChRI. Similar changes are admitted to be found at the hypothalamus level as well. According to the authors the hormonal dysbalance in the female patients with ChRI is the cause for the grave changes observed in the genital cycle.

Adult↗

PubMed1981

[Plasma levels of follicle-stimulating and luteinizing hormones, prolactin and estradiol in women with chronic kidney failure on programmed hemodialysis].

The plasma level of FSH, LH, P and E of 24 women with CRI, aged from 16-61, on a programmed hemodialysis was determined, 13 of them with Balkan endemic nephropathy, 8--chronic pyelonephritis and one patient with chronic glomerulonephritis, polycystosis of kidneys and lupus nephritis. The patients were grouped into three groups according to age and genital cycle: with genital cycle--10, secondary amenorrhea--7, and in menopause--7. The patients with genital cycle were grouped as follows: 4 with eumenorrea, 4--opsomenorrhea and I with hyper- and I with hypomenorrhea. Plasma hormone level prior to and post hemodialysis was determined by radioimmunologic methods. The results obtained showed that FSH levels, as compared with the control group of healthy women, was unchanged, LH and P--was elevated and E was elevated only in the patients with genital cycle. No significant discrepancy was found in the levels of the hormones studied, in the three groups of females with CRI on programmed hemodialysis (with genital cycle, secondary amenorrhea and menopause), except for E in the women with cycle. The studies of the authors showed that plasma levels of FSH, LH, P and E prior to and post hemodialysis, are insignificantly changed. That provided grounds to admit that the hormones are nondialysable. The authors admit that the programmed hemodialysis is a treatment method by which the genital cycle in some CRI patients with secondary amenorrhea could be restored.

Adolescent↗

PubMed1981

[Hypophyseal anal ovarian disorders in chronic kidney failure].

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Adult↗