[The behavior of granulocyte oxidases in neuroleptoanalgesia].
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Biomedical subjects
Publications and source records attributed to S Testa.
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The pancreas is usually well recognized by ultrasound, but in some cases it is obscured by the presence of gas in the stomach and duodenum. Water and other orally administered fluids produced poor results. In this study we stimulated pancreatic juice secretion by a standard dose of intravenous secretin in 24 normal subjects, and continuously monitored the pancreatic region for a period of 20 min. Four to five minutes after hormone administration pancreatic juice outflow into the duodenum generated a fluid-filled echofree area around the head of the pancreas, allowing excellent visualization of its boundaries and other channel structures (distal common bile duct, pancreatic duct and gastroduodenal artery). This method should be utilized in selected patients whenever a pathological condition of the pancreatic head region is suspected.
The effects of self-directed in vivo exposure in the treatment of panic disorder with agoraphobia were examined. Seventy-four chronic and severe agoraphobic subjects were randomly assigned to Cognitive Therapy plus graded exposure. Relaxation Training plus graded exposure, or therapist-assisted graded exposure alone. Treatment consisted of 16 weekly 2.5-hour sessions. All subjects received programmed practice instructions for engaging in self-directed exposure as a concomitant strategy to their primary treatment. All subjects were instructed to keep systematic behavioral diary recordings of all self-directed exposure practice. The diary data were analyzed across and within treatments and assessment phases. Statistically significant findings were obtained across all diary measure domains with powerful repeated measures effects observed across all treatments. Significant between group effects and treatment x repeated measures interactions were obtained across the diary measure domains. Multiple linear regressions of in vivo anxiety levels and, to a lesser extent, frequency of self-directed exposure practice were found to be significantly associated with global assessment of severity at posttreatment and 3-month follow-up assessments. Furthermore, depression and marital satisfaction were significantly associated with in vivo anxiety. These and other findings are discussed with regard to their conceptual and clinical implications.
Arterial hypertension (AH), either primary or secondary, is an important issue in childhood for its short- and long-term cardiovascular morbidity. Renal diseases are the most frequent causes of AH in children, but essential hypertension can also be detected early in life. It is important for blood pressure (BP) to be checked regularly (at least once every 5 years) in healthy children and adolescents and every year in those belonging to at-risk categories (family history of AH, low birth weight, obesity, etc). In children, AH is defined as BP recorded in three non-consecutive measurements with an appropriate device and cuff size > or = 95th centile for age, gender and height. Ambulatory BP monitoring is a valuable diagnostic tool and once AH is confirmed, a specific primary cause should always be ruled out (renovascular, cardiac, vascular, endocrine, pharmacologic, other). In case of border-line or significant AH (between 90th and 99th centile) a non-pharmacological treatment should be considered, whereas severe hypertension (>99th centile for height and age) will require pharmacological treatment (Diuretics, Angiotensin Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, beta - and Calcium blockers).
Direct revascularization which involve the femoro-popliteo-tibial district is called "limbs salvage" surgery. Such operations are performed in the arteriopathic patient in order to avoid ulcers and distal necrosis, whose natural evolution, without an adequate treatment, leads to amputation. One of the distal by-pass techniques is obtained by using in situ saphenous vein. The Authors report their experience with 281 patients who underwent direct revascularization surgery (by-pass), discussing technique and results.
Although there is no etiopathogenetic correlation between arterial diseases and gastroduodenal ulcer, a chronic gastric disease can increase postoperative morbidity and mortality, in patients with arterial diseases. Furthermore, postoperative complications due to the development of acute hemorrhagic gastritis are frequent and dangerous, even in patients without any pre-existing gastric pathology. The experience of our Department in this field is reported here, and the risk and severity of hemorrhagic complications after administration of prophylaxis in patients with arterial diseases and gastroduodenal ulcer are evaluated.
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An assessment was made of the blood lipid pattern in a group of patients in critical situations subjected to T.P.N. with a mixed calorie intake (sugars, lipids, amino acids). It was found that the pronounced previous deficiency was corrected in a significantly shorter period, and that despite the large load on calories in the form of fats there were no changes worthy of note in the body fluids. Serial determination of lipoproteins before, during and after T.P.N. substantiated the clinical findings. Lab checks, within the limits set by intuitive variations, did not reveal alterations with a pathological meaning, for the very reason that they were not linked to organic enzyme and hormone deficiencies, but were positive changes attributable to the temporary exogenous input.
Various metabolic disturbances (hydroelectrolytic and basic acid imbalances, hypo- and hyper- glycaemia etc.) are among the possible complications of N.P.T. A comparative statistical study of similar patients undergoing N.P.T. and others not so treated demonstrates that far from stimulating metabolic disturbances, N.P.T. is able to reduce the incidence of such conditions.
The renal complications in course of malaria have notably increased in number during the last years, as well as the cases of malaria in the world. This subject and a case of malaria in the world. This subject and a case of renal complication in course of malaria we could recently observe led us to re-examine the papers in which this problem was debated. Only the Pl. malaria and the Pl. falciparum can cause renal complications, as the first can produce a nephrosic syndrome and the second an acute renal insufficiency functional or organic, or a glomerulonephritis more often acute transitory, which can rarely develop into a nephrosic syndrome or into an acute renal organic insufficiency. Then the various physiopathologic causes of the acute renal insufficiency, of the glomerulonephritis, of the nephrosic syndrome are described, followed by a case description of an acute renal functional insufficiency in course of malaria caused by Pl. falciparum.