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Biomedical subjects

S Widgren

Publications and source records attributed to S Widgren.

At least 19 recordsLinked to original sources
PubMed2001

[Giardia lamblia gastritis. A case report].

A 56 year-old male patient had a gastric resection (Billroth II) at age 33. In 1993 he had vague upper digestive complaints. During investigations for a moderate anaemia biopsies performed during an oesogastroduodenoscopy revealed a jejunitis with Giardia lamblia (G.l.) trophozoites which were also found on the gastric mucosa associated with Helicobacter pylori related chronic active gastritis. The few publications dealing with the presence of Giardia lamblia in the stomach either assert or cast some doubts on the pathogenicity of this protozoa for the gastric mucosa. Gastric involvement by G.l. is usually associated with duodeno-jejunal disease responsible for diarrhoea which may occur as epidemics of varying extension. Since Giardia lamblia infection is not submitted to reporting in Switzerland, the epidemiology in our country is scarcely known and investigated. In our opinion, however, health authorities in Switzerland should consider the need of reporting this infectious disease.

Animals↗
PubMed1997

Inflammatory fibroid polyp in a continent ileo-anal pouch after colectomy for ulcerative colitis--case report.

The most frequent complication occurring in continent ileo-anal pouches after colectomy for ulcerative colitis (UC) is pouchitis. Recurrences of adenomas or carcinomas in pouches of familial adenomatous polyposis (FAP) patients are exceptional, whereas in those with ulcerative colitis dysplasia it is a very rare occurrence. We describe the case of a young woman who developed a mass in a J pouch three years after its construction following colectomy for ulcerative colitis. Histological and immunohistochemical studies showed that this mass had the features of an inflammatory fibroid polyp. A review of the literature of lesions observed in continent ileo-anal pouches after colectomy for UC would suggest that this lesion is an exceedingly rare complication of those devices.

Adult↗
PubMed1994

[Enterocolitis due to a saponin-containing drug. Apropos of a case].

The case of a 60-year-old female patient with watery diarrhea is reported. The history was characterized by prolonged diagnostic vagaries, due in part to histological features of ileal, rectal and duodenal biopsies which were suggestive of celiac disease. This was clinically excluded. After halting the intake of a compound drug containing saponins, administered for venous insufficiency, the diarrhea ceased immediately but could be provoked by rechallenge with the same drug. The patient thus had drug induced chronic diarrhea mimicking celiac disease, a condition which is less rare than is thought and easily diagnosed by a thorough enquiry on drug intake.

Biopsy↗
PubMed1992

[Bone marrow involvement in Whipple's disease].

The authors present the case of a 57 years old woman who had atypical Whipple's disease characterized solely by migratory arthralgia, weight loss and unexplained anemia which had lasted for 5 years. Once the diagnosis of Whipple's disease was established on abdominal lymph node biopsy, the retrospective study of a bone marrow biopsy revealed the presence of PAS-positive sickle-formed particles within medullary macrophages. Review of the literature attests the rarity of ante-mortem diagnosis of Whipple's disease in bone marrow preparations. We suggest that bone marrow biopsies stained with the PAS technique be employed in clinical settings of chronic migratory arthralgia and unexplained anemia.

Anemia↗
PubMed1991

Acinic cell carcinoma of minor salivary gland origin.

The occurrence of acinic cell carcinoma in the minor salivary glands appears to be exceptional. A review of the English language literature revealed about 80 previously reported cases. In this paper, the clinical behaviour and pathological findings in three cases are reported. The tumours took their origin from the hard palate, soft palate and lower lip. The three cases presented with malignant clinical behaviour; all three recurred. In one case the local recurrence was multinodular with capsular infiltration. Two cases developed regional lymph node metastasis, and one metastasized to the lung and liver. In one the tumour infiltrated bony structures, and nerve in another. These cases tend to support the belief of some authors that acinic cell 'tumours' are clinically malignant and should be included in the carcinoma group.

Aged↗
PubMed1990

Collagenous colitis with protracted course and fatal evolution. Report of a case.

We report the case of a female patient who suffered from collagenous colitis for 13 years, the complications of which may have contributed to her death. The disease was associated with seropositive rheumatoid arthritis and Sjögren's syndrome. Cases of collagenous colitis with a course leading to death have not been reported in the literature, to the best of our knowledge.

Aged↗
PubMed1990

[Perforated tubular duplication of the sigmoid colon in adults].

Intestinal duplications are rare malformations and a diagnostic challenge. The case presented herein relates to a perforated tubular duplication of the sigmoid colon in a 23-year-old man with intermittent abdominal pain during 3 months and a bout of peritonitis which resolved spontaneously. This case is unusual since duplications generally spare adults, are seldom found in the colon, and do not perforate. The only cases of duplication which can be suspected preoperatively belong to the communicating type or those containing ectopic gastric mucosa. The intraoperative finding in this case of a malformative mesenteric cyst reminds us that duplications can be found in association with other intestinal, vertebral, or genitourinary tract malformations. In conclusion, intestinal duplications should be resected even when they are asymptomatic, as occasional cancerous transformation associated with a poor prognosis have been reported.

Abscess↗
PubMed1990

Dermoid cyst of the pancreas. Case report and review of the literature.

During an annual check-up in a 46 year-old man, a round mass was discovered in the left hypochondrium upon abdominal ultrasonography. Computed tomographic scan located the mass at the upper border of the body of the pancreas, suggesting an expansive process. Left pancreatectomy was performed, leading to the discovery of a dermoid cyst. This cyst was apparently part of the pancreatic parenchyma. Only 11 cases of dermoid cysts of the pancreas have been reported between 1918 and 1977. Elective enucleation of the cyst is thought to be adequate surgical treatment.

Dermoid Cyst↗
PubMed1990

[Digestive amyloidosis with ischemic ulcer of the colon in a chronic hemodialysis patient].

A 78 year old male patient who had been treated by haemodialysis for 17 years for renal failure, secondary to tuberculosis, is reported. Following severe rectal bleeding, an ischaemic ulcer of the ascending colon was noticed, which required right hemicolectomy. On the surgical specimen, the ulcer showed massive vascular involvement with amyloidosis of the type found in haemodialysed patients, and constituted of beta 2 micro-globulin deposits. These amyloid deposits have certainly played an important part in the development of this ischaemic lesion.

Aged↗
PubMed1989

Colonic pericryptal fibroblasts. Differentiation pattern in embryogenesis and phenotypic modulation in epithelial proliferative lesions.

Experimental evidence has shown that fetal gut mesenchymal cells can modulate epithelial cell differentiation. It is postulated that reciprocal stromal-epithelial interactions in the digestive tract are maintained beyond embryonic life. The mature colonic mucosa contains pericryptal fibroblasts (PCF), a stromal cell type exhibiting smooth muscle morphological features, which are thought to regulate the growth and differentiation of adjacent epithelial cells. Using an antibody directed at alpha-smooth muscle actin, which is constantly expressed in smooth muscle cells, we performed an immuno-histochemical study on human embryonic tissues to assess PCF differentiation during development. PCF expressing alpha-smooth muscle actin were first detected around the 21st week of gestation, at the bases of the crypts; the number of differentiated PCF increased then progressively, in synchrony with epithelial proliferation, to achieve at birth the characteristic distribution found in adults. We analyzed a series of non-malignant and malignant epithelial proliferative lesions of the adult colon by the same technique. Only sparse immunoreactive PCF were observed in 10/10 pure tubular adenomas, whereas in 11/11 villous adenomas immunoreactive PCF were consistently found bordering proliferative epithelia. Interestingly, 3/5 papillary adenomas, associated with areas of moderate to marked dysplasia, demonstrated foci of multilayered immunoreactive PCF. In 14/14 carcinomas examined, PCF were no longer recognizable; stromal cells expressing variable amounts of alpha-smooth muscle actin, constituting the desmoplastic reaction, were constantly present. These observations establish immunohistochemically a smooth muscle phenotypic feature of PCF, which is acquired at mid-gestation, and the ability of PCF to proliferate in conjunction with some epithelial neoplasias. These findings might help to clarify the histogenesis of PCF and to improve our understanding of the mesenchymal-epithelial interactions suspected to operate during organogenesis as well as benign and malignant neoplastic conditions.

Actins↗
PubMed1988

Collagenous colitis: histologic, morphometric, immunohistochemical and ultrastructural studies. Report of 21 cases.

We examined 129 colonic biopsies from 21 patients with collagenous colitis, most of whom presented with diarrhoea. Morphometric measurements gave a mean thickness of the subepithelial collagen deposit of 19.5 mu +/- 5.1. The trapped fusiform and/or stellate cells within the deposits were identified immunohistochemically as myoid cells, being positive with antibody against smooth muscle cell alpha-actin. Ultrastructurally, these cells have all the characteristic features of myofibroblasts. Similar cells are also present along the crypts, where they were formerly referred to as pericryptal fibroblasts. Although there is still much debate as to the pathogenesis of this condition, we would like to suggest that collagenous colitis is a disease of pericryptal myofibroblasts. During their migration and maturation into the subepithelial region they may synthesize an excess of collagen, under some yet unknown or undefined stimulus/stimuli.

Adult↗