Biomedical subjects

Suchada Chantrapromma

Publications and source records attributed to Suchada Chantrapromma.

At least 19 recordsLinked to original sources

PubMed2004

Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam.

A cardenolide glycoside, 3 beta-O-(2'-O-acetyl-l- thevetosyl)-15(14-->8)-abeo-5 beta-(8R)-14-oxo-card-20(22)-enolide (2'-O-acetyl cerleaside A), was isolated from a methylene chloride extract of the seeds of Cerbera odollam, together with four known compounds: cerleaside A, 17 alpha-neriifolin, 17 beta- neriifolin and cerberin. Their structures were elucidated by spectroscopic methods. All compounds except cerleaside A exhibited cytotoxic activities against oral human epidermoid carcinoma (KB), human breast cancer cell (BC) and human small cell lung cancer (NCI-H187).

Antineoplastic Agents, Phytogenic↗

PubMed2003

Redetermination of hydronium perchlorate at 193 and 293 K.

A sample of hydronium perchlorate, H(3)O(+) x ClO(4)(-), crystallized from ethanol at ambient temperature, was found to be orthorhombic (space group Pnma) at both 193 and 293 K, with no phase transition observed in this temperature range. This contrasts with the earlier observation [Nordman (1962). Acta Cryst. 15, 18-23] of a monoclinic phase (space group P2(1)/n) at 193 K for crystals grown at that temperature from perchloric acid. The hydronium and perchlorate ions lie across a mirror plane but it is not possible to define at either temperature a simple description of the H-atom positions due to the three-dimensional tumbling of the hydronium cation.

Journal Article↗

PubMed2003

Polymeric structure of (ethylenediamine)silver(I) 3-nitrobenzoate monohydrate.

In the ternary title compound, catena-poly[[silver(I)-mu-ethylenediamine-kappa(2)N:N'] 3-nitrobenzoate monohydrate], [[Ag(C(2)H(8)N(2))](C(7)H(4)NO(4)) x H(2)O](n), the Ag atom is bicoordinated in a linear configuration by two different N atoms from two symmetry-related ethylenediamine ligands, thus giving linear polymeric chains with an [-Ag-N-C-C-N-](n) backbone running parallel to the a axis. In the crystal packing, these linear chains are interconnected by N-H...O and O-H...O hydrogen bonds to form layers parallel to the ab plane.

Journal Article↗

PubMed2003

Bis[14beta-hydroxy-3beta-O-(L-thevetosyl)-5beta-card-20(22)-enolide] methanol solvate monohydrate and 3beta-O-(L-2'-o-acetylthevetosyl)-14beta-hydroxy-5beta-card-20(22)-enolide.

The title compounds, 2C(30)H(46)O(8).CH(3)OH.H(2)O, (I), and C(32)H(48)O(9), (II), respectively, are cardenolide glycosides which were isolated from the seeds of Cerbera odollam. There are two crystallographically independent cardenolide molecules in (I), together with one methanol and one water solvate molecule. In both (I) and (II), the steroid nuclei are in cis/trans/cis configurations, with the cyclopentane rings showing conformational flexibility, viz. an envelope conformation in (I) and a twisted conformation in (II). In both compounds, the lactone ring is nearly orthogonal to the cyclopentane ring. The packing of (I) is composed of molecular layers stabilized by five O-H...O hydrogen bonds. In the packing of (II), the molecules are packed into columns by one O-H...O hydrogen bond, and are further interconnected into a three-dimensional network by one O-H...O and three C-H...O interactions.

Apocynaceae↗

PubMed2002

Barium(II)-2,4-dinitrophenolate-18-crown-6 at 183 K.

The title compound, bis(2,4-dinitrophenolato-kappa2O,O')(1,4,7,10,13,16-hexaoxadecane-kappa6O)barium(II), [Ba(C6H3N2O5)2(C12H24O6)], is a 1:1 complex of barium(II)-2,4-dinitrophenolate and 1,4,7,10,13,16-hexaoxacyclooctadecane (18-crown-6). Its structure is located on a crystallographic inversion centre. The temperature dependence of the crystal structure has been studied. The monoclinic beta angle of the P2(1)/n space group increases with increasing temperature. The packing structure of the complex is stabilized by intermolecular C-H...O interactions.

Journal Article↗

PubMed2002

Hexamethylenetetramine-4-nitrocatechol-water (1/2/1).

In the title adduct, 1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decane-4-nitrobenzene-1,2-diol-water (1/2/1), C(6)H(12)N(4).2C(6)H(5)NO(4).H(2)O, the hexamethylenetetramine molecule acts as an acceptor of intermolecular O-H.N hydrogen-bonding interactions from the water molecule and the hydroxy groups of one of the two symmetry-independent 4-nitrocatechol molecules. The structure is built from molecular layers which are stabilized by three intermolecular O-H.O, two intermolecular O-H.N and four intermolecular C-H.O hydrogen bonds. The layers are further interconnected by one additional intermolecular O-H.N and two intermolecular C-H.O hydrogen bonds.

Journal Article↗

PubMed2002

Di-2-pyridyl ketone N4,N4-(butane-1,4-diyl)thiosemicarbazone.

The title compound, C(16)H(17)N(5)S, is in the thione form and crystallizes with two independent molecules in the asymmetric unit. In both molecules, the pentamethyleneimine five-membered ring adopts an envelope conformation, and in one of the molecules this ring shows positional disorder. The thione S and hydrazine N atoms are in the Z configuration with respect to the C-N bond.

Journal Article↗

PubMed2002

A ternary complex of aqua(18-crown-6)bis(o-nitrophenolato)barium(II), the triaqua(18-crown-6)(o-nitrophenolato)barium(II) cation and the o-nitrophenolate anion.

In the title compound [systematic name: triaqua(1,4,7,10,13,16-hexaoxacyclooctadecane-kappa(6)O)(2-nitrophenolato-kappaO)barium(II)-aqua(1,4,7,10,13,16-hexaoxacyclooctadecane-kappa(6)O)bis(2-nitrophenolato-kappa(2)O,O')barium(II)-2-nitrophenolate (1/1/1)], [Ba(C(12)H(24)O(6))(C(6)H(4)NO(3))(H(2)O)(3)][Ba(C(12)H(24)O(6))(C(6)H(4)NO(3))(2)(H(2)O)](C(6)H(4)NO(3)), the two Ba(II) atoms encapsulated by the 18-crown-6 rings have different coordinations. Although both Ba(II) atoms are coordinated to the six O atoms of the crowns, in the neutral moiety, the Ba(II) atom is coordinated to one terminal O atom from a water molecule, two phenolate O atoms and two nitro-group O atoms, while in the cationic moiety, the Ba(II) atom is coordinated to three terminal O atoms from water molecules and one phenolate O atom. Both the crowns are eclipsed and translated along the b direction. In the asymmetric unit, the three components are interconnected by four O-H.O interactions. The packing is stabilized by two intermolecular C-H.O interactions and by one O-H.O interaction.

Journal Article↗

PubMed2002

Di-mu-sulfido-bis[diaqua(18-crown-6)barium(II)]-saccharin (1/2).

The molecule of the title compound [systematic name: di-mu-sulfido-bis[diaqua(1,4,7,10,13,16-hexaoxacyclooctadecane-kappa(6)O)barium(II)] bis[1,2-benzisothiazol-3(2H)-one 1,1-dioxide]], [Ba(2)S(2)(C(12)H(24)O(6))(2)(H(2)O)(4)](C(7)H(5)NO(3)S)(2), lies on an inversion centre. The Ba(II) atom encapsulated by the 18-crown-6 ring is coordinated by the six O atoms of the crown, two water O atoms and two bridging S atoms. The four-membered ring composed of the Ba(II) atoms and the bridging S atoms makes a dihedral angle of 67.1 (1) degrees with the crown-ether ring. The aromatic ring system of the saccharin moiety is essentially planar. The packing is built up from layers of the molecules and is stabilized by three intermolecular O-H.O hydrogen bonds.

Journal Article↗

PubMed2002

The ternary complex 4-(2-pyridyl)pyridinium-3,5-dinitrobenzoate-3,5-dinitrobenzoic acid (1/1/1).

In the title ternary complex, C(10)H(9)N(2)(+).C(7)H(3)N(2)O(6)(-).C(7)H(4)N(2)O(6), the pyridinium cation adopts the role of the donor in an intermolecular N-H.O hydrogen-bonding interaction with the carboxylate group of the 3,5-dinitrobenzoate anion. The molecules of the ternary complex form molecular ribbons perpendicular to the b direction, which are stabilized by one N-H.O, one O-H.O and five C-H.O intermolecular hydrogen bonds. The ribbons are further interconnected by three intermolecular C-H.O hydrogen bonds into a three-dimensional network.

Journal Article↗

PubMed2002

Bis[1-(pyridin-2-yl)ethanone-kappa N 4-phenylthiosemicarbazonato-kappa 2N4,S]manganese(II).

One half of the molecule of the title complex, [Mn(C(14)H(13)N(4)S)(2)], is related to the other half by a twofold axis passing through the Mn atom. This high-spin Mn atom is six-coordinated, in an octahedral geometry, by the azomethine N, the pyridyl N and the thiolate S atom of two planar 1-(pyridin-2-yl)ethanone N(4)-phenylthiosemicarbazone ligands. In the crystal, the molecules are interconnected by N-H.S and C-H.N interactions, forming a three-dimensional network.

Journal Article↗

PubMed2002

11-Methyl-12a-phenyl-9a,12a-dihydrophenanthro[9',10:5,6][1,4]dioxino[2,3-d]thiazole.

In the title compound, C(24)H(17)NO(2)S, the dioxine and thiazoline rings are distorted from planarity towards a half-chair and an envelope conformation, respectively. The configurations of the dioxine ring, the thiazoline ring and the attached phenyl ring are conditioned by the sp(3) state of the two bridgehead C atoms. The phenanthrene system is nearly coplanar with the dioxine ring, while the attached phenyl ring is orthogonal to the thiazoline ring.

Journal Article↗

PubMed2002

11-Methyl-12a-phenyl-9a,12a-dihydrophenanthro[9',10':5,6][1,4]dioxino[2,3-d]oxazole and 9a-(10-hydroxyphenanthren-9-yl)-11,12a-diphenyl-9a,12a-dihydrophenanthro[9',10':5,6][1,4]dioxino[2,3-d]oxazole.

In the title compounds, C(24)H(17)NO(3), (I), and C(43)H(27)NO(5), (II), the dioxine ring is not planar and tends toward a boat conformation. The oxazoline ring adopts a twisted conformation in molecule (I) but is essentially planar in molecule (II). The configuration of the dioxine-oxazoline system is determined by the sp(3) state of the two shared atoms. The phenanthrene moiety is nearly coplanar with the dioxine ring, while the phenyl ring is perpendicular to the attached oxazole ring. The triclinic unit cell of (II) contains two crystallographically independent molecules related by a pseudo-inversion centre.

Journal Article↗

PubMed2002

(Dibenzyl sulfoxide-kappa O)bis(1,3-diphenylpropane-1,3-dionato-kappa(2)O,O')dioxouranium(VI).

In the title compound, [UO(2)(C(15)H(11)O(2))(2)(C(14)H(14)OS)], the U(VI) atom is coordinated by seven O atoms in a distorted pentagonal-bipyramidal geometry. Both diphenylpropane-1,3-dionate systems are nearly planar. The sulfoxide moiety is in a distorted tetrahedral geometry, while its two aromatic rings are nearly orthogonal to one another. The crystal packing is stabilized by two bifurcated hydrogen-bonding interactions involving both uranyl O atoms.

Journal Article↗

PubMed2002

1-Acetyl-3'-(4-bromophenyl)-3'-chlorospiro[3H-indole-3,2'-oxetan]-2(1H)-one.

In the title compound, C(18)H(13)BrClNO(3), the heterocyclic ring of the indole is distorted from planarity towards an envelope conformation. The orientations of the indole, oxetane, chloro and bromophenyl substituents are conditioned by the sp(3) states of the spiro-junction and the Cl-attached C atoms.

Journal Article↗

PubMed2002

1-Acetyl-3-[1-(4-methoxyphenyl)-2-oxopropylidene]-1H-indol-2(3H)-one: a twinned crystal.

The crystal of the title compound, C(20)H(17)NO(4), which was used for collecting intensity data was twinned. Each of the two crystallographically independent molecules in the asymmetric unit has a planar indole moiety perpendicular to a planar oxopropyl moiety. The distribution of the bonds at the central C atom joining the oxopropyl, phenyl and indole substituents is also planar. The packing is stabilized by intermolecular C-H* * *O interactions, as well as by dipole-dipole and van der Waals interactions.

Journal Article↗

PubMed2002

Formation of molecular ladder elements with macrocyclic platforms via linear bifunctional ligands.

Reaction between 4-aminopyridine and a dinuclear zinc(II) component of a Robson macrocyclic ligand has resulted in the formation of a molecular ladder element motif. X-ray single crystal structural analysis indicates that two pyridine rings are assembled at the same direction of the macrocycle, which are placed in a nearly parallel way via pi-pi interactions, forming a concavity structure with a macrocyclic base. It is significantly noted that one hydrogen-bond cycle generated from hydrogen atoms of two amino groups with two perchlorate anions has sustained such an assembly of two 4-aminopyridine species to stand in a face to face pattern through a weak molecular interaction on the macrocyclic platform by one-end coordination bonding. The self-assembly of 4-carboxylic pyridine acid and the same macrocyclic component in the presence of sodium hydroxide has yielded an interesting wheel-like complex. Two macrocyclic dinuclear zinc(II) components have been linked through coordination bonding with two pyridine derivatives situated on the same direction of a macrocycle. X-ray structural results suggest that the compound has a unique sandwich-like structure consisting of two macrocyclic covers with two inversely positioned bridging pyridine carboxylic groups in the middle.

Journal Article↗

PubMed2002

Piperazine-1,4-diium--2,4-dinitrophenolate--water (1/2/2).

In the title 1/2/2 adduct, C(4)H(12)N(2)(2+) x 2C(6)H(3)N(2)O(5)(-) x 2H(2)O, the dication lies on a crystallographic inversion centre and the asymmetric unit also has one anion and one water molecule in general positions. The 2,4-dinitrophenolate anions and the water molecules are linked by two O-H...O and two C-H...O hydrogen bonds to form molecular ribbons, which extend along the b direction. The piperazine dication acts as a donor for bifurcated N-H...O hydrogen bonds with the phenolate O atom and with the O atom of the o-nitro group. Six symmetry-related molecular ribbons are linked to a piperazine dication by N---H.O and C---H.O hydrogen bonds.

Journal Article↗