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Biomedical subjects

T Anzai

Publications and source records attributed to T Anzai.

At least 145 records · Page 8Linked to original sources
PubMed1985

[Giant aneurysm of the right coronary artery with complete proximal obstruction: a case report].

A 46-year-old woman was admitted to our hospital for evaluation of oppressive chest pain and ECG abnormalities. Her ECG on admission showed old inferior myocardial infarction. Chest radiography on admission indicated cardiomegaly (cardiothoracic ratio was 60%). The echocardiogram showed compression of the right atrium, right ventricle, and tricuspid annulus by a tumor which was located between the liver and the heart. The tumor's echo density was heterogenous. Cardiac computed tomography showed compression of the tricuspid annulus by the tumor which was located anterior to the right atrium and the right ventricle. The tumor registered 65.1 HU and was not enhanced by contrast medium. These findings strongly suggested a giant right coronary aneurysm filled with thrombus, and this diagnosis was confirmed at surgery and pathologically. Coronary aneurysms are rarely diagnosed during life, and usually are incidental findings during coronary arteriography performed to evaluate myocardial infarction or angina pectoris. The coronary aneurysm of the present case was clearly and easily recognized using computed tomography and appeared as a pericardial tumor. Computed tomography may be helpful for observing the growth of tumor and thrombus formation within it.

Aneurysm↗
PubMed1984

Relationship between ototoxicity of aminoglycoside antibiotics and their transferability into inner ear fluids.

The purpose of this study is to clarify the question whether the difference of severity of ototoxicity induced by the aminoglycoside antibiotics depends on the difference of quantity of transferability into inner ear. Aminoglycoside antibiotics (tobramycin, kanamycin, netilmicin and ribostamycin) were injected for 30 consecutive days to rabbits. The relationship between the severity of hair cell damage and concentration of antibiotics in perilymph was investigated. The drug concentration in the perilymph was determined by the bioassay method, and using the surface preparation technique the hair cell damage was observed under a phase contrast microscope. It was concluded that the difference of severity of ototoxicity induced by the aminoglycoside antibiotics is due to the difference of their own toxicity to hair cells but not to the difference of their transferability into the perilymph.

Aminoglycosides↗
PubMed1984

Mechanism of protective effect of fosfomycin against aminoglycoside ototoxicity.

The purpose of this study was to clarify the mechanism of the protective effect of fosfomycin (FOM) against inner ear damage induced by an aminoglycoside dibekacin (DKB), when administered concurrently DKB and FOM. Rats were treated with 50 mg/kg of DKB with or without 500 mg/kg of FOM for short-term administration. No significant difference was seen in the serum peak level and in the area under the curve between the group receiving DKB alone and the combined administration group of DKB and FOM. On the other hand, the DKB level in the kidney was significantly lower in the combined administration group than in the group receiving DKB alone. The mechanism of protective effect of FOM against DKB-induced ototoxicity may be considered as follows: FOM inhibits the accumulation of DKB in the kidney and reduces its concentration in the kidney and serum. Consequently, the transferability of DKB into the inner ear is decreased, and finally inner ear damage is reduced.

Animals↗
PubMed1984

[Reduction of cisplatin toxicity by fosfomycin in animal models].

The protective effect of fosfomycin against cisplatin-induced toxicities was studied in rats. A total of 64 Fischer rats were injected intravenously with daily doses of 1, 2, 5 and 10 mg/kg of cisplatin with or without 300 mg/kg of fosfomycin for a period varying from 1 to 10 days. The same total dose of 10 mg/kg of cisplatin was given to all animals. Cisplatin-induced toxic side-effects of body weight loss, nephrotoxicity and ototoxicity were significantly reduced functionally or histopathologically by the combined administration of cisplatin and fosfomycin. A comparison of different dosage schedules with a total dose of 10 mg/kg of cisplatin showed that a higher daily dose for a shorter time period produced more marked toxicities.

Alanine Transaminase↗
PubMed1983

Lipolytic activity of crude or partially purified lipase of the mouse mammary gland at various substrate concentrations.

The lipolytic activity in crude extracts prepared from mouse mammary glands during lactation and pregnancy or that in extracts partially purified with anion exchange chromatography and ammonium sulfate precipitation depended on the ratio of the extract volume to the substrate amount in the assay emulsion. When the ratio was high, the fatty acid release ceased within a short time of incubation. In this case, the substrate concentration available for the lipase dropped. This decline was considered to occur due to the interaction of the substrate with some substance in the extracts.

Animals↗
PubMed1982

Persistent fifth aortic arch left subclavian aneurysm in an adult.

Persistent fifth aortic arch is so rare an anomaly that only seven cases have been reported. We treated an adult with this anomaly in which there was a single lumen aortic arch, single arterial trunk and left subclavian aneurysm. The patient underwent corrective surgery. From an analysis of the eight cases, this anomaly can be divided into two groups, depending on the aortic arch. The first group of six had double lumen aortic arch. All in this group had intra and/or extra cardiac anomalies, and only two with only PDA underwent ligation. The second group of two had a single lumen aortic arch and corrective surgery was done. Thus, those patients with a persistent fifth aortic arch should be classed into the first or second group, according to the angiographical findings.

Adult↗
PubMed1982

[Pericardial puncture under the ultrasonic cardiotomographic guidance: application to pericardial effusion].

Pericardial puncture drainage was attempted in five patients with pericardial effusion under the guidance of real time two-dimensional echocardiography (ultrasonic cardiotomography). The needle fixed to the scanner probe was inserted from the anterior chest wall under the observation of ultrasound images. After the needle was placed into the pericardial space, then the drainage catheter was introduced according to the Seldinger technique. The image of the needle should be appropriately monitored from the site of puncture as near as possible because the pericardium is so close to the anterior chest wall. Both mechanical and linear sector scanners were used in this study, and linear type was proved to be useful for this purpose. It was concluded that the pericardial puncture under the guidance of ultrasonic cardiotomography is safer and reliable compared to the conventional blind puncture technique.

Adult↗