Biomedical subjects

T Chimura

Publications and source records attributed to T Chimura.

103 records · Page 6Linked to original sources

PubMed1982

[Effect of infusion therapy on intrauterine fetal growth retardation (author's transl)].

It is requested for the control to the intrauterine fetal growth retardation (IUGR) to clarify the cause-and-effect relationship and to take the proper treatment under such a precondition. Following report covers the clinical report on the maternal infusion therapy mainly consisting of amino acids. 1) In the cases, to which the diagnosis of IUGR was given on basis of the development of symphisis-fundus length on the pregnogram and the fetal biparietal diameter (BPD), the occurrence of appropriate-for-gestational-age (AGA) is as extremely high as 44.5% when it is felt without treatment. In the abnormal patterns of symphisis-fundus length, consisting mainly of the threatened premature labor, the differential diagnosis is needed to the outward IUGR. 2) As the effect of the maternal infusion therapy mainly of amino acids on IUGR, given in addition to the oral nutrition, the increase of placental weight and fetal weight was observed at around NP-Cal/N of 99-116. No abnormality was observed in the maternal renal and liver function. 3) As the result of the maternal infusion therapy to 131 cases of IUGR, the occurrence ratio of the small-for-gestational-age (SGA) was 26.7%. No case of perinatal death or congenital malformation was observed.

Adult↗

PubMed1982

[Influences of indomethacin on the cardiovascular and metabolic systems of fetuses].

The influences of indomethacin--a drug with prostaglandins inhibiting effect--on the cardiovascular and metabolic systems of fetuses were studied. 1) 1mg/day of indomethacin was administered subcutaneously to pregnant Wister rats for 5-6 days. The rats were administered laparotomyon on the 21st day of conception, and the histopathological changes of the lungs of the fetuses were studied. The findings demonstrated no histopathological changes due to indomethacin nor any hypertrophy of the smooth muscles in the small arteries of the lungs. 2) 10-35mg of indomethacin was administered intravenously to rabbits in the final stages of pregnancy, thus, indomethacin was absorbed into the maternal livers, placentas, fetal livers, maternal plasmas, and amniotic fluids as the serum concentrations of indomethacin increased with each added dosage. The percentile changes in relation to the maternal plasma concentration values revealed high percentages in fetal livers, followed by placentas, maternal livers, and fetal plasmas. Amniotic fluid concentrations were as low as 20 percent. 3) As for the clinical results of the use of indomethacin (N = 302), tocolysis showed that abortions numbered 7 out of 101 (5.3%), premature births 63 out of 155 (40.6%), SFD 14 out of 302 (4.6%), perinatal deaths 8 out of 302 (2.6%), and deaths due to distress 3 out of 302 (1%). No neonatal pulmonary hypertension was observed in the 8 premature infants that were delivered dead.

Amniotic Fluid↗

PubMed1981

[Cardiovascular and metabolic effects during longtime treatment with beta 2-stimulants (author's transl)].

To study the influence of beta 2-stimulants on pregnant woman and fetus from cardiovascular and metabolic viewpoint, tests were conducted on pregnant rats and human clinical cases of threatened premature labor. 1) When terbutaline 800 micrograms was administered to groups of pregnant rats for 4 days and 8 days, body weight, and weight of liver, placenta and heart of both mother and fetus indicated the trend of decrease when compared to the control, but the difference was not statistically significant. 2) Concentration of c-AMP in the fetal serum was found to be less than the control (P less than 0.001) under the above conditions and consequently c-AMP/c-GMP indicated decrease. Concentrations of c-AMP and c-GMP in the maternal, fetal cardiac tissue were in a decreasing tendency in the terbutaline group. In the patholo-histological studies, terbutaline-induced myocardial necrosis was not observed. 3) In the past five years, of the terbutaline treated cases, specifically 15 cases of large dose and long period of administration were analyzed and the prognosis of their children were followed up. The doses were 20.6 mg (iv, im), and 1276 mg (po), arrest less than 37W was noted in four cases, but onset of SFD was not observed. During the administration term, no abnormality of mothers was noted before and after delivery, and unusual phenomenon was not recognized in the prognosis traced on newborns.

Adult↗

PubMed1981

[beta 1, beta 2-effects of ritodrine in pregnant animal experiments (author's transl)].

beta 2-Stimulant are at present the most effective tocolytic agents. The purpose of this paper is to outline the beta 1-, beta 2-effects of ritodrine in animal experiments. 1) In the pregnant rat uterus at term, ritodrine and terbutaline showed the potent effect. The c-GMP level in the bath medium was significantly decreased by the administration of ritodrine, while the c-AMP levels was significantly increased. 2) When the changes in the maternal serum c-AMP and c-GMP levels after the administration of ritodrine were examined, these results coincided with those obtained experiments in vitro. But decreased in c-AMP and c-GMP levels by administering beta-blocker. The c-AMP and c-GMP levels of placenta, liver, uterus and fetus showed similar patterns, especially c-AMP in the uterine and fetal tissues increased when ritodrine was administered. 3) The administration of ritodrine and terbutaline at the last trimester of pregnancy led to the increased, showing dose-response relationship, in the heart rate of mother and fetus in rabbits. 4) The effect of ritodrine on fetal and neonatal serum glucose concentrations was examined in rats. Sustained hypoglycemia was observed in fetus and neonate delivered within 18 hours of the termination of administration (ritodrine, 10-20 mg, sc).

Animals↗

PubMed1981

[Beta 1-, beta 2-effects of ritrodine and terbutaline in the treatment of preterm labor (author's transl)].

beta 2-Stimulants are at present the most effective tocolytic agents. The aim of the study was to evaluate the beta 1- . beta 2-effects of terbutaline and ritodrine in the treatment of preterm labor. 1) Terbutaline, administered intravenously at a rate of 0.4-1.2 microgram/min, and ritodrine also at a rate of 50-300 microgram/min, effectively inhibited uterine activity during 180 minutes. Among the patients there was no difference in responses between those who received terbutaline and ritodrine. 2) The levels of c-AMP and c-GMP in the blood after administration of terbutaline or ritodrine increased and showed dose-response. The levels of c-AMP during a 180-minute infusion increased from 15 to 27 pmol/ml. 3) The action of c-AMP related substances on the circulatory systems was manifested as the dose-response of beta 1 action to the maternal blood pressure, maternal and fetal heart rate. Both beta 2-stimulants produced a tolerable changes in maternal heart rate and blood pressure, no significant changes during the infusion.

Cyclic AMP↗

PubMed1980

The comparative actions of uterine inhibiting drugs in the pregnant rat.

Studies were made to determine the effect of various contraction-inhibitors against spontaneous uterine contraction in rats during late pregnancy. 1) The duration and rate of inhibitory activity differed from inhibitor to inhibitor, showing dose-response relationship. As a result of this investigation of the changes in the intensity and frequency for 17 inhibitors, Ca-blocker, beta 2-stimulants and dibutyryl c-AMP had the strongest effects, PG-antagonist, and the anti-inflammatory drugs such as aminophylline were much weaker in their inhibitory activity. 2) When the progress of uterine inhibition was investigated on the basis of quantitative changes of PG and c-AMP in bath medium, it was found that both PGE1 and PGF2 alpha were significantly reduced after administration of terbutaline and indomethacin, c-AMP decreased significantly after administration of PGE1 analogue, oxytocin and PGF2 alpha. The c-AMP levels increased significantly after administration of terbutaline and verapamil. These were no significant changes in c-AMP levels when indomethacin and aminophylline were used. During the administration of the uterine inhibitors, c-AMP increased significantly both in vivo and in vitro. Therefore, c-AMP may be regarded as an important parameter indicating the degree of inhibition of contraction.

Adrenergic beta-Agonists↗

PubMed1980

The treatment of threatened premature labor by drugs.

CLINICAL STUDIES: There are many reports describing the extent of uterine excitement in vitro and clinical conditions of uterine contractions at the time of threatened premature labor. Changes in blood levels of c-AMP, Ca and PG appear to be the most useful parameters for uterine contraction and relaxation. 1) The blood level of c-AMP during threatened premature labor increased when any of the uterine inhibitors went administered. 2) An inhibitory effect was also seen with intravenous administration of dibutyryl c-AMP, an analogue of c-APM. When the inhibitory effects against threatened premature labor by various inhibitors were classified by their inhibitory pattern, terbutaline and dibutyryl c-AMP had the a strongest and quickest effect, whereas ethanol and indomethacin were weaker and slower in promoting the onset of their activities. 3) Analysis of 263 cases of threatened premature labor treated in our department in the past 5 years demonstrated that there are 2 phases of contraction during premature labor. They are the active phase and the depressed phase. The active phase is best treated with beta 2-stimulants whereas the drug of choice for the depressed phase can be varied to suit the clinical situation.

Bucladesine↗

PubMed1972