PubMed Health⌕ Search

Biomedical subjects

T Decsi

Publications and source records attributed to T Decsi.

62 records · Page 4Linked to original sources
PubMed1988

The metabolic and hormonal effects of continuous subcutaneous insulin infusion therapy in diabetic children.

To find out whether the concurrent metabolic and hormonal abnormalities are corrected when normoglycaemia is achieved, two groups of diabetic children (newly-diagnosed and chronically-treated) were treated with insulin pumps. Fasting levels of metabolites, lipids and hormones were measured before and after 8 to 10 days of pump treatment and the immediate postprandial hormonal and metabolic changes after a test-meal were also measured. Restoration of normoglycaemia was accompanied by correction of multiple metabolic abnormalities including the normalisation of fasting plasma free insulin, growth hormone, free fatty acid, triglyceride and total cholesterol levels. Plasma glucagon, however, decreased below normal, and significant hypoketonaemia developed in newly-diagnosed diabetic children. The fall in (VLDL + LDL)-cholesterol levels was accompanied by a substantial increase in HDL2-cholesterol concentration in newly-diagnosed diabetic children, whereas pump-treatment resulted in a decrease of the HDL3-cholesterol subfraction in chronically-treated diabetic children. The postprandial blood glucose and free insulin profiles were similar to that of control subjects, but there was an "abnormal" postmeal fall in plasma glucagon and free fatty acid levels. These changes together with the fasting hypoglucagonaemia and hypoketonaemia indirectly suggest that optimal glycaemic control is only achievable at the expense of "increased insulin action" despite the failure to detect peripheral hyperinsulinaemia. Furthermore, the restoration of normoglycaemia and the simultaneous normalisation of the metabolic and endocrine milieu is not entirely possible with this mode of therapy.

Adolescent↗
PubMed1988

Resting energy expenditure and food-induced thermogenesis in diabetic children receiving continuous subcutaneous insulin infusion.

The effect of short-term (8-10 days) optimal glycaemic control achieved by continuous subcutaneous insulin infusion on resting energy expenditure and food-induced thermogenesis was studied. Oxygen consumption and carbon dioxide production were measured by indirect calorimetry in six newly-diagnosed and six chronically-treated diabetic children before and following the consumption of a standardized test meal. The metabolic and hormonal responses to the test meal and nutrient utilization were also assessed and compared with those measured in nine non-diabetic children. The restoration of normoglycaemia was accompanied by hypoglucagonaemia, hypoketonaemia, increased insulin:glucagon ratio and abnormal postmeal fall in free fatty acid levels in spite of normal fasting and post-prandial plasma free insulin levels. These changes suggesting increased insulin action were most pronounced in newly-diagnosed diabetic children. Possibly as a result of increased insulin action high carbohydrate, low fat utilization and increased food-induced thermogenesis were observed in the newly-diagnosed diabetic children. In the chronically-treated group these parameters were approaching the normal. Resting energy expenditure was normal in both groups of diabetics. These findings suggest that precise glycaemic control can be achieved only at the expense of some degree of peripheral hyperinsulinisation which leads to altered nutrient utilization and food-induced thermogenesis in the newly-diagnosed diabetic children.

Adolescent↗
PubMed1986

Severe hypertension in a ten-year-old boy secondary to an aldosterone-producing tumour identified by adrenal sonography.

Severe hypertension discovered incidentally in a 10 year-old boy was associated with persistent hypokalaemia and metabolic alkalosis. Primary hyperaldosteronism was diagnosed by demonstrating elevated plasma aldosterone levels and increased urinary aldosterone excretion with concomitant depressed plasma renin activity. Adrenal sonography identified a left adrenal adenoma which was removed surgically; normotension and normalization of plasma renin and aldosterone values ensued. This appeared to be the first use in children of sonography to identify adrenal adenoma and it is suggested to be the first step in the differential diagnosis of primary hyperaldosteronism.

Adenoma↗
PubMed1986

Early postnatal growth in preterm infants.

Changes in weight of 50 preterm infants (gestational age 32.7 +/- 0.3 weeks, birthweight 1772 +/- 49 g) were studied during the period of the 0-4 postnatal weeks. Intrauterine weight gain of fetuses with equivalent gestational age, weight percentile position and sex was calculated and used as a control. Study infants achieved significantly less weight by age of 4 weeks (116.2 +/- 1.2%) than it could have been expected theoretically (144.7 +/- 1.0%). Growth performance did not correlate significantly with calorie intake, but was closely related with gestational age.

Birth Weight↗
PubMedDate not supplied

Lipid levels in very low birthweight preterm infants.

Free fatty acid (FFA), triglyceride (TG),total cholesterol (T-C), VLDL + LDL-C, HDL-C and its subfractions were determined in 18 very low birthweight (birthweight: 1064 +/- 179 g; gestational age: 28.7 +/- 1.6 weeks, mean +/- SD) preterm infants on postnatal days 1, 14, 28, 42 and 56 (data are given in mmol/l). FFA levels remained low throughout the study (day 1: 0.13 +/- 0.09 ... day 28: 0.15 +/- 0.06...day 56: 0.16 +/- 0.06). TG levels increased significantly from day 1 to 14 and from day 14 to 28 (day 1: 0.61 +/- 0.26, day 14: 1.14 +/- 0.28, day 28: 1.70 +/- 0.89), thereafter they remained unchanged. T-C levels increased significantly from day 1 (2.29 +/- 0.83) to day 14 (3.05 +/- 0.71), continued to increase up to day 28 (3.34 +/- 1.58), subsequently decreasing to the level of day 1 (day 56: 2.63 +/- 0.87). More marked alterations were seen in VLDL + LDL-C (day 1: 1.51 +/- 0.70, day 28: 2.32 +/- 1.34, day 56: 1.76 +/- 0.74), whereas in HDL-C it was HDL2-C that changed significantly.

Female↗