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Biomedical subjects

T Decsi

Publications and source records attributed to T Decsi.

At least 55 records · Page 3Linked to original sources
PubMed1995

Vitamin E status of low birthweight infants fed formula enriched with long-chain polyunsaturated fatty acids.

It is recommended in Europe that low birthweight infants (LBWI) who do not receive human milk (HM) should be fed formula enriched with long-chain polyunsaturated fatty acids (LCP). The question has been raised whether LCP supplementation to LBWI formula may have adverse effects on antioxidant status in the recipient infant, particularly on the major lipid-soluble antioxidant vitamin E (alpha-tocopherol, alpha-toc.). We studied alpha-toc. status in LBWI fed HM (n = 15) or formula either without (f, n = 8) or with LCP derived from egg lipids and fish oil (LCP-F, n = 9) on days 4 and 21 of life. Plasma alpha-toc. concentrations increased significantly in infants fed HM [d. 4: 4.53 (1.31), d. 21: 6.35 (2.18), mg/l, mean (SD), p < 0.01], whereas there were no changes in infants fed F of LCP-F. Plasma alpha-toc./total lipid ratios and erythrocyte membrane alpha-toc. concentrations did not change significantly between days 4 and 21 in either group. In contrast, erythrocyte membrane alpha-toc./total lipid ratios decreased significantly in infants fed LCP-F [0.42 (0.13) vs. 0.31 (0.06), p < 0.05], whereas no change occurred in the other two groups. We conclude that an LCP supplementation based on egg lipids and fish oil to formula may induce an early postnatal decrease of alpha-toc./total lipid ratios in erythrocyte membranes of LBWI. Therefore, the effects of different forms of LCP supplementation to infant formula on infantile vitamin E status should be carefully evaluated.

Erythrocyte Membrane↗
PubMed1994

Fatty acid composition of plasma lipid classes in healthy subjects from birth to young adulthood.

The fatty acid (FA) composition of plasma phospholipids, triglycerides and cholesterol esters (STE) was determined by high resolution capillary gas-chromatography in 115 apparently healthy subjects from birth to young adulthood. After birth, percentage contributions of linoleic and alpha-linolenic acid increased, whereas long-chain polyunsaturated fatty acids decreased in all FA fractions. No difference in plasma FA composition was seen between groups of children aged 1-< 5, 5-<10 and 10-<15 years, except for a decrease of total saturated FA in STE between 1-<5 years (18.5%, wt/wt) and 10-<15 years (14.5%, P < 0.005). No difference was observed for the values of boys and girls. The results on plasma lipid FA distribution in children aged 1-15 years may be used as reference values for metabolic and nutritional investigations.

Adolescent↗
PubMed1994

Polyunsaturated fatty acids in infant nutrition.

The availability of long-chain polyunsaturated fatty acids (LCP), such as arachidonic (C20:4n-6) and docosahexaenoic (C22:6n-3) acids, is important for early human growth and development. The capacity for endogenous synthesis of LCP from the precursor fatty acids linoleic (C18:2n-6) and alpha-linolenic (C18:3n-3) acid is limited in preterm and probably also in term infants. In utero, LCPs seem to be transferred preferentially from the mother to the foetus by the placenta. After birth, breast-fed infants receive preformed dietary LCP with human milk. In contrast, most current infant formulae are devoid of LCP. Premature infants fed such formulae develop rapid LCP depletion of plasma and tissue lipids, which is associated with reduced visual acuity during the first postnatal months. Therefore, LCP enrichment of formulae for premature infants is desirable. Recent observations indicate that term infants fed conventional formulae also exhibit lower plasma LCP values and may show functional disadvantages, but these data require further confirmation prior to drawing definite conclusions.

Breast Feeding↗
PubMed1993

Lipid and apolipoprotein levels and enteral nutrition in very low-birth-weight preterm infants.

Lipid, lipoprotein cholesterol and apolipoprotein A-I, A-II and B levels were determined in 10 very low-birth-weight (birth weight 1279 +/- 144 g; gestational age 29.2 +/- 1.2 weeks, mean +/- SD) preterm infants on postnatal days 3, 10 and 21. Feeding with pooled human milk began on day 3 +/- 1 and by day 10 all infants were exclusively enterally fed. Both triglyceride and total cholesterol levels increased significantly from day 3 to day 10 (0.84 +/- 0.28 versus 1.53 +/- 0.72 and 2.42 +/- 0.47 versus 3.24 +/- 0.80, mmol/l, respectively) (p < 0.01); thereafter no further increase was observed. The increase in total cholesterol level was primarily due to a significant enhancement of very low-density lipoprotein and low-density lipoprotein cholesterol (1.52 +/- 0.34 versus 2.29 +/- 0.73 mmol/l, p < 0.01). Apo A-I, A-II and B levels did not change between day 3 and day 10. From day 10 to day 21, however, a significant increase in apo A-I concentration was noted (0.57 +/- 0.20 versus 0.87 +/- 0.17 g/l, p < 0.01), whereas apo A-II levels increased significantly from day 3 to 21 (0.15 +/- 0.03 versus 0.27 +/- 0.08 g/l, p < 0.01). No change in apo B level was seen.

Aging↗
PubMed1992

[Mortality among mature neonates requiring intensive care].

Causes of mortality among term infants hospitalized in a Neonatal Intensive Care Unit during a period of five years were investigated. Among the 107 fatal cases analyzed, congenital malformation was the cause of death in 63 and hypoxia/asphyxia in 35 cases, whereas 9 newborns died primarily of infection. Though congenital malformation is the leading cause of mortality, nevertheless, also perinatal asphyxia and primary and secondary infections play an important role. The utmost importance of prevention and proper medical care is emphasized.

Asphyxia Neonatorum↗
PubMed1992

[Comparison of human milk with 3 different types of infant food in the nutrition of full-term neonates].

Healthy, term infants who were either breast-fed, or received conventional formula (Mildibé, EGIS; Pre-Aptamil, Milupa), or a formula containing hydrolyzed proteins (Aptamil H. A., Milupa) were investigated. Each group consisted of 10 infants who were fed ad libitum. Somatic development (gain in weight, length and head- and chest circumferences), serum Ca and P levels, alkaline phosphatase activities and basic biochemical parameters of protein metabolism (serum total protein, albumin, uric acid, creatinine and urea nitrogen levels) were determined at the ages of 2, 4 and 8 weeks. Anthropometric measurements did not reveal considerable differences between the groups investigated. At the age of four weeks, serum calcium levels were significantly higher in the breast-fed infants than in those receiving formula. Both at the ages of four and eight weeks, serum total protein levels were significantly lower in the infants receiving the formula consisting of hydrolyzed proteins than in the breast-fed controls. No difference of considerable extent was seen in the other biochemical parameters measured. The results obtained indicate that, in the lack of the possibility of breast-feeding, all the three formulae investigated can be used as substitute of breast milk.

Breast Feeding↗
PubMed1992

[Glycosylated proteins, blood sugar levels and postnatal growth in very low birth weight (less than 1500 g) neonates].

The concentration of HbA1c, glycosilated serum proteins and blood glucose were followed up during the first eight postnatal weeks in 10 preterm babies of mean (+/- SD) birthweight and gestational age of 1259 +/- 140 g and 30.2 +/- 2.0 weeks, respectively. Both blood glucose and the glucosilation of proteins remained unchanged over the study period. No relationship was found either between growth rate and blood glucose level, or the latter and HbA1c concentration. Statistically significant correlationship could be observed between carbohydrate and total calorie intake and growth rate, but only during the first four postnatal weeks.

Blood Glucose↗
PubMed1992

Electrolyte and glucose concentration in plasma and cerebrospinal fluid measured parallel in pathologic newborn infants.

Cerebrospinal fluid and plasma sodium, potassium, chloride, calcium and glucose concentration were measured parallel in 14 pathological newborn babies of gestational age and birthweight of 36.3 +/- 4.3 wks and 2410 +/- 890 g, respectively, at the age of 37.8 +/- 4.4 wks postconceptionally. Whilst potassium, calcium and glucose level is much lower in the cerebrospinal fluid than in the plasma, similar sodium and higher chloride concentration was found in the cerebrospinal fluid. The significant positive correlation between plasma and cerebrospinal fluid glucose and sodium levels proves the lack of a functioning barrier for these compounds. On the other hand, cerebrospinal potassium level varied within a narrow range, independently of the plasma-concentration and the maturity of the studied babies. Pathophysiological implications of the results are further discussed in short.

Blood Glucose↗
PubMed1992

Campomelic dysplasia without campomelia.

We present a male infant with campomelic dysplasia syndrome (McKusick 21197) in whom no bowing of the tibiae or femora was seen, but widely set nipples and long upper segment of the arm were observed. In accordance with two previous case reports, the present findings suggest that a campomelic dysplasia variant without campomelia may exist.

Abnormalities, Multiple↗
PubMed1991

[Calcium, phosphorus, magnesium status and postnatal growth during 0-8 weeks in low birth weight premature infants].

Mineral intake and biochemical parameters of calcium, phosphorus and magnesium metabolism were studied during the first eight postnatal weeks in 12 very low birthweight preterm infants. However, the intake of calcium and phosphorus was less than that generally advised in the relevant literature, only marginally lowered serum mineral concentration and no rise in alkaline phosphatase activity were found. Urinary calcium/creatinine and phosphorus/creatinine ratio did not reflect mineral deficiency either. At the same time, a significant inverse correlation was found between postnatal growth rate and calcium excretion in the study babies, whose postnatal growth rate was much less than the control foetal growth rate. The authors briefly discuss the main aspects of neonatal mineral supply and homeostasis.

Calcium↗
PubMed1991

[Lipid- and lipoprotein-cholesterol levels in the first 8 months of low-weight (less than or equal to 1500 g) premature infants].

Lipid levels were determined in 30 low birthweight (less than or equal to 1500 g) preterm infants (birthweight: 1122 +/- 192 g, gestational age: 29,0 +/- 1,7 weeks, mean +/- SD) on the 1st, 14th, 28th, 42nd and 56th days of life. Triglyceride and cholesterol were measured by a Boehringer kit, while HDL-cholesterol and its subfractions by microprecipitation methods. Both triglyceride and cholesterol levels increased significantly from the 1st to the 14th and from the 14th to the 28th days. VLDL + LDL-cholesterol level increased significantly by the 14th day, while HDL-cholesterol level by the 28th day. From the 1st to the 14th day the increment of cholesterol levels was significantly higher in breast milk-fed newborns (n = 18) than in those receiving formula (n = 12). Consequently, on the 14th, 28th and 42nd days cholesterol levels were significantly higher in breast milk-fed newborns than in those receiving formula. By the age of two months, however, the difference diminished.

Cholesterol↗
PubMed1990

Postnatal weight gain and serum total protein and albumin levels in very low birthweight (less than or equal to 1500 g) preterm infants.

Postnatal weight gain during the first 8 weeks of life of 20 very low birthweight preterm infants (gestational age: 28.9 +/- 1.7 weeks, birthweight: 1098 +/- 199 g, mean +/- SD) was compared to the in utero weight gain of theoretical control fetuses. By the end of the study period preterm infants gained significantly less weight than their controls (155 +/- 15 vs 221 +/- 16%, p less than 0.001). During the first 6 weeks of life daily additional weight gain of the preterm infants was less than that of the controls, but after that time no significant difference was seen (7th-8th week: 12.0 +/- 3.6 vs 13.7 +/- 3.9 g/kg/day, study infants vs controls, ns). During the 7th-8th weeks of life positive correlation was found between calorie intake and weight gain (r = 0.33, F = 2.17, p less than 0.05). The changes in serum total protein and albumin levels, including an initial increase by the age of 2 weeks, were statistically not significant.

Blood Proteins↗
PubMed1990

Early postnatal changes of immunoglobulin levels in very low birth weight (less than or equal to 1500 g) preterm infants.

Immunoglobulin levels were measured in 16 very low birth weight preterm infants (birth weight: 1091 +/- 221 g, gestational age: 28.8 +/- 1.6 wks, mean +/- SD) at birth and at postnatal ages of 2, 4, 6 and 8 weeks. IgM level increased significantly by the age of 2 weeks (0.26 +/- 0.25 g/l vs 0.76 +/- 0.45 g/l, p less than 0.05), then remained unchanged throughout the study period. IgA level did not change significantly. IgG level decreased significantly by the age of 6 weeks (6.04 +/- 3.8 g/l vs 4.4 +/- 1.4 g/l, p less than 0.05), but after that no further decrease could be detected. The extent of the decrease in IgG level, however, proved to be smaller than expected on the basis of the reference data for term infants. The possibility is suggested that the packed red cell transfusions given to the patients may have resulted in the higher immunoglobulin levels.

Blood Transfusion↗