PubMed Health⌕ Search

Biomedical subjects

T Dutkiewicz

Publications and source records attributed to T Dutkiewicz.

50 records · Page 3Linked to original sources
PubMed1977

Experimental studies on arsenic absorption routes in rats.

Pentavalent inorganic arsenic was introduced by intravenous, intratracheal, gastrointestinal, and skin application in doses 0.1 to 4.0 mg/kg in rats. Isotopic technics were applied by use of As(74). It was found that the dynamics of arsenic distribution in the body as well as the kinetics of its elimination in urine and feces varies very substantially, depending on the mode of administration. Intravenous administration of As causes immediate appearance of arsenic in most tissues and a slow decrease of its concentrations in time. Similar situations could be observed with intratracheal dosing, because arsenic is very rapidly absorbed from the site of administration. Concentration in tissues increases more slowly after gastrointestinal resorption. Skin application causes first the accumulation of arsenic in the skin and next continuous, slow transport from the skin into the blood stream. The rate of skin resorption was 1.14-33.1 mug/cm(2)-hr for 0.01-0.2M concentrations. The red blood cell level of arsenic is very substantial and does not change with time, which indicates the accumulation of arsenic in this tissue. The elimination of arsenic occurred chiefly in urine and feces, but the urine/feces ratio changed very substantially, depending on the route of administration. The kinetics of arsenic elimination in urine was multiphasic, being three-phase in case of intravenous and intratracheal administration and two-phase after gavage and skin resorption. After intravenous administration of As, the half-times of elimination were 2.5, 10, and 690 hr, respectively. Administration of selenium salts during the slow phase increased the rate of arsenic elimination. The straight-line relations found between the absorbed dose of arsenic and its blood or urine concentrations could serve as baselines for exposure tests for humans.

Administration, Oral↗
PubMedDate not supplied

Comparative studies on the influence of decapitation, ketamine and thiopental anesthesia on rat heart mitochondria.

The influence of decapitation, ketamine and thiopental anesthesia on some properties of rat heart mitochondria was compared. Polarographic analysis were performed, oxygen consumption rates, respiratory control index, ADP : O ratio and oxidation of exogenous NADH were determined. Electronmicroscopic and gasometric examinations were also conducted. Mitochondrial fractions from hearts of decapitated rats oxidized at a generally faster rate and mitochondria from such hearts exhibited a significantly lower RCI value. These differences can be explained through the action of uncoupler(s) present in the decapitated group. A hypothesis linking decapitation with the uncoupling effect of fatty acids released intracellularly during catecholamine-stimulated lipolysis is discussed. No differences in the ADP : O ratio and electronmicroscopic details between the groups were found. Gasometric determinations in both anesthetized groups did not show any marked dysfunction of the respiratory system. It is concluded that decapitation leads to some changes in the functional integrity of rat heart mitochondria. Ketamine and thiopental anesthesia can be used with equal success for the isolation of mitochondria from the heart.

Adenosine Diphosphate↗
PubMedDate not supplied

Evaluation of regional environmental and health hazards by applying synthetic measures.

Large geographical areas, urban and rural regions of 49 voivodships in Poland, were evaluated from the point of view of existing environmental and health hazards caused by chemical contamination of the environment. Using routine sources of information, we selected four health-related environmental indicators and eight environmental-related health indicators. All indicator values were normalized and then aggregated to synthetic measures of environmental and health hazards, using the taxonometric method. The synthetic measures characterized the urban and rural regions of the entire country and were used for their ranking for remedial purposes. A consistency of environmental and health synthetic measures was found in urban regions (correlation coefficient r = 0.58). The spatial distribution of environmental and health hazards was determined using geo-graphical information system (GIS) methods. The application of kriging and the interpolation of data improved the interpretation of the results. The worst situation was found in the southwest regions of Poland, which are heavily industrialized with a high population density.

Environmental Monitoring↗