PubMed Health⌕ Search

Biomedical subjects

T Erdmann

Publications and source records attributed to T Erdmann.

At least 19 recordsLinked to original sources
PubMed2004

Stability of adhesion clusters under constant force.

We solve the stochastic equations for a cluster of parallel bonds with shared constant loading, rebinding, and the completely dissociated state as an absorbing boundary. In the small force regime, cluster lifetime grows only logarithmically with bond number for weak rebinding, but exponentially for strong rebinding. Therefore rebinding is essential to ensure physiological lifetimes. The number of bonds decays exponentially with time for most cases, but in the intermediate force regime a small increase in loading can lead to much faster decay. This effect might be used by cell-matrix adhesions to induce signaling events through cytoskeletal loading.

Cell Adhesion↗
PubMed1990

[Factors influencing the result of kidney transplantation with special reference to the HLA system in conventional immunosuppression].

Among 331 recipients of cadaveric renal allografts, transplanted from 1976 to 1986 at the Rostock Transplant Center the graft survival rates have been analyzed. All patients have been treated by conventional immunosuppressive therapy using azathioprine and prednisolone. A relation between graft survival and immunological factors was found: the better the HLA match, the better the transplant results. The necessity of a restrictive transfusion regime was stressed. The higher the number of pretransplant transfusions, the higher is the panel reactivity with following lower graft survival. Cold ischemic time was without influence on graft survival. The introduction of cyclosporin may improve the graft survival rate as known of 10-20%.

Azathioprine↗
PubMed1989

[Retrograde ejaculation from the urologic viewpoint and the current status of therapeutic possibilities].

The successful treatment of ejaculatory disturbances is an unresolved problem even today, especially in the patient group of young men after retroperitoneal lymph node dissection because of testicular cancer. A promising therapeutic measure is the treatment with alpha-sympathicomimetics as Pryleugan and Gutron. Pryleugan is recommended as a first- line treatment, whereas Gutron is indicated after failure of this initial therapy. After unsuccessful medical treatment a procedure of sperm production, conservation and insemination is presented. A close cooperation between urologists and gynecologists is necessary for higher therapeutic success rates in ejaculatory disturbances.

Ejaculation↗
PubMed1988

Electron microscopic results on the ventral prostate of the rat after CdCl2 administration. A contribution towards etiology of the cancer of the prostate.

The prostate epithelium of rats which received repeated cadmium chloride (CdCl2) injections showed a gradual disruption of structural differentiation. Electron microscopy studies revealed severe changes in the ultrastructure affecting all epithelial cell organelles, particularly the nuclei, rough endoplasmatic reticulum, the golgi apparatus, and mitochondria. The cells infiltrating the stroma contained secretory vacuoles and their nuclear evaginations on the invasion front showed similarities to ultrastructural pathological changes in man. Examinations of the ventral prostate following oral CdCl2 administration revealed changes ranging in severity up to dysplasia, but there was no evidence of carcinoma.

Administration, Oral↗
PubMed1987

[Relations between atypical hyperplasia, dysplasia and prostatic cancer and the significance of its appearance for the clinician].

In 89 preparations of patients with a carcinoma of the prostate and 100 preparations of patients with a hyperplasia of the prostate (adenoma of the neck of the bladder) the appearance of primarily atypical hyperplasias was investigated. In these cases in the carcinoma group in the uniform as well as in the pluriform carcinomas a coincidence of carcinoma and atypical hyperplasia of 55% was found. The coincidence is particularly high in adenocarcinomas and in carcinomas with dominating adenoid part, respectively, i. e. in more mature glandular structures. Among the various histological types of the atypical hyperplasia the microglandular/papillary clear-cellular form is dominating with 82%. In the group of the benign hyperplasia of the prostate gland a coincidence of the atypical hyperplasia of 33% was found. Though this rate, in comparison to other investigators, seems to be relatively high, it is still significantly lower than in the carcinoma. From this follows that the atypical hyperplasia, particularly its severest forms and dysplastic deformations from other hyperplasias (postatrophic hyperplasia, basal cell hyperplasia, atrophy and metaplasia of the prostate) now as ever are suspected that these cases in question are precancerous lesions. For the clinically working urologist the task is derived in such histopathological diagnoses by clinical and bioptical follow-up controls to find an already existing, but still unrecognized, or developing carcinoma of the prostate gland. In no case the diagnosis may cause surplus therapeutic consequences.

Adenocarcinoma↗
PubMed1986

[Dielectric behavior of isolated dog kidneys following storage preservation and subsequent autotransplantation].

A measurement of the vitality of kidney transplants before the implantation is not yet possible, however, criteria for the proof of anoxic and hypothermic lesions on isolate kidneys are known. With the investigation means of the passive-electric behaviour over the determination of the DK-course and the dispersion of epsilon' an original evaluation of the vitality is possible. With the help of the measurement of epsilon' in frequencies between 0.5 MHz and 3 MHz we establish the proportion of intact cell membranes and mitochondria. The modul M3 explains the distribution of relaxing structures. Our hitherto performed experiments have shown that by means of the observation of the two sizes a judgment of the vitality seems to be possible. Examinations on bastard dogs of either sex were performed. For the supplementation of the dielectric measurements in certain time intervals tissue samples of the preserved kidneys were investigated electron-microscopically.

Animals↗
PubMed1985

Carcinogenic effects of cadmium on the prostate of the rat.

The carcinogenic effects of cadmium were tested in an animal experiment to check the results of epidemiological studies showing that the incidence of prostatic carcinoma is above average in workers industrially exposed to high cadmium levels. For this purpose 1.9 mg CdCl2 (1.2 mg Cd/kg body weight) was injected into the right ventral prostatic lobe of 12-month-old male inbred rats of the Okamoto-toki strain. Simple hyperplasia was found in 38, atypical hyperplasia in 29, atypical hyperplasia with severe dysplasia in 11 and invasive prostatic carcinoma in 5 of 100 animals 270 days after the injection. Various mechanisms are discussed in connection with the carcinogenic action of cadmium.

Animals↗
PubMed1984

[Microsurgical blood vessel reconstruction in kidney transplantation].

Of 214 donor kidney transplants, 14.5% exhibited multiple arterial supply, 2.8%, injuries to vessels, and 1.8%, severance of the polar vessel. Microsurgical procedures were used on 14 of these kidneys; 11 functioned immediately, so that the patients could be discharged. Techniques of anastomosis using an operating microscope or magnifying spectacles are described.

Cadaver↗
PubMed1984

[Radical prostatovesiculectomy in the treatment of prostate cancer. Indications, operative technic and personal results].

Cancer of the prostate is the most common form of carcinoma in males of advanced age. If treated at an early stage, it can be healed by prostatovesiculectomy. Rectal prophylactic examination of all males aged 45 years or more should therefore be performed on a larger scale in order to detect these carcinomas as early as possible. Radical operation is indicated in males younger than 70 years old from stage T1 up to stages T3 and M0. Criteria vary in regard of the N-categories. The surgical technique practiced in the perineal and retropubic approach to prostatovesiculectomy is described, advantages and disadvantages are dealt with. No complete urinary incontinence could be observed in the 20 patients who underwent this operation at our hospital. Only 1 patient suffers from severe stress-induced incontinence, all others experiencing no difficulty in this respect. In 2 cases rectal lesions occurred during the operation. Postsurgical strictures occurring in the region of the urethra-bladder anastomosis in 2 other patients could be eliminated by internal urethrotomy. Impotence is the most common complication following this operation.

Adult↗
PubMed1983

[Therapeutic attitude of kidney transplantation patients--initial results of a psychological test study].

After kidney transplantation the patient is subject to psychological stress due to problem situations. To date these problems have described only in very general clinical terms. Initial results of a psychological study on 26 kidney-transplant patients allow us to recognize factors which influence the patients' attitude to the disease and therapy. Such factors are: success of therapy, emotional tension, attitude towards the doctor and the self-confidence of the patient. The doctor-patient relation corresponds to the attitude towards therapy only in the immediate post-operative period and in patients with a negative attitude towards therapy. In the assessment of the doctor-patient relation it is only of medium importance whether the patient likes the doctor. The Study is being continued.

Adolescent↗
PubMed1982

[Immunologic after-care after organ transplantation using the electrophoretic mobility test].

55 of 113 receivers of cadaver donor kidney transplants could be control-examined and analysed postoperatively immunologically with the electrophoresis mobility test (EM test). A high coincidence appears in the group with clinical rejection symptoms and a rejections hint in the EM test (28 of 29) and also in the group with the rejection clinically not conceivable and with a negative test result (20 of 26). The EM test appears suitable for an additional support of the diagnosis "acute rejection". More cases should confirm this assertion.

Cell Movement↗