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T Fernández Aparicio

Publications and source records attributed to T Fernández Aparicio.

At least 19 recordsLinked to original sources
PubMed2003

[Use of statistical analysis in original articles in "Actas Urológicas Españolas." Accessibility for the reader].

OBJECTIVES: To describe the use of statistical methods employed in original articles published in Actas Urológicas Españolas as the first step to quantify the accessability for the readers. METHODS: Observational, retrospective, descriptive and transversal study to analize all the original articles published in Actas Urológicas Españolas during the year 2000. Once the anectotic cases were excluded, 55 original studies were selected. In each article it was minuciously reviewed the methods and results sections, tables and figures included, to identify the statistical analysis used and to classify them into 18 categories with three accessability levels as Emerson and Colditz and Mora y cols, previously reported: descriptive statistics, bivariables analysis and complex analysis. A randomized sample of the originals were reviewed again by the same investigator three months later to evaluate the criteria liability. The accessability was defined as a) article dependent (rate of originals that readers with different statistical knowledge are able to understand) and b) analysis dependent (rate of statistical methods respect to the total performed overall the articles that readers are able to understand). RESULTS: Our major findings are that the more frequently used technics are descriptive analysis (39.3%), bivariable tables (12.1%), survival analysis (10%), t Student and z tests (6%), and nonparametric tests (8.6%). The accessability for a reader which statistical konowledge includes bivariable methods is 63.6% (IC 95% 49%-76%) and 79% (IC 95% 71%-85), article and analysis dependent respectively, rates that are similar to the reported for biomedical journals in our country. CONCLUSIONS: A great percentage of original articles in Actas Urológicas Españolas includes complex analysis. It could be good that readers were able to increase our statistical and methodological knowledge to perform a critical approach to our publication.

Bibliometrics↗
PubMed2002

[Extramedullary hematopoiesis, a simulator difficult to diagnose].

The extramodular hematopoiesis is the result of the bone marrow sever chronical hypofunction, being the genitourinary affection very unusual. We are presenting a singular case by its own clinicopathology consequences and exceptional incidence in context of a upper tract urothelial tumor.

Aged↗
PubMed2001

[Experience with cadaver renal transplant with ex situ reconstructed arteries].

OBJECTIVE: To review our experience with cadaveric kidney transplantation with ex situ reconstruction of damaged renal artery. METHODS: To obtain a minimum follow-up of 5 years, 20 cases treated from January 1989 to December 1994 were retrospectively reviewed. The control group comprised 73 patients that had received an "ideal" graft during the same period. Both groups were similar for all the variables that could influence graft outcome. RESULTS: Both groups showed similar results for incidence of NTA, rejection episodes, creatinine values, surgical complications or reoperations. However, a strong trend (25% of the cases) to develop renal artery stenosis was found (p = 0.052). These latter cases were diagnosed by the onset of arterial hypertension that was difficult to control and were treated conservatively by percutaneous angioplasty with good functional results in 100% of the cases, although 80% required more than one session. This complication, however, did not lead to graft failure. CONCLUSIONS: Renal grafts with arteries damaged during procurement or as a result of pathological changes, such as arteriorclerosis or aneurysm, are useful after bench reconstruction before transplantation. However, the greater trend to develop symptomatic arterial stenosis that has been observed makes it convenient to look for this complication routinely during follow-up. If diagnosed and treated early, it does not influence the graft outcome. The therapeutic approach is first by percutaneous transluminal angioplasty and if it fails, then by open surgery.

Adolescent↗
PubMed2000

[Cadaver kidney grafts from donors over 60 years of age should be considered as suboptimal].

Considering the scarcity of organs for transplantation, one possible solution is the use of grafts from aged donors (over 50 years). We have reviewed our experience in the case of kidney transplantation considering the period from 1989-1994 in order to attain a minimum follow-up of 36 months. We compare three groups: donors aged between 50-60 years (n = 32), donors aged over 60 years (n = 25) and a control group formed by donors of "ideal" ages. The results show that kidneys from donors over 60 years evidence, as compared to the control group, a higher incidence of acute tubular necrosis (p = 0.032), significantly higher blood creatinine levels in all the intervals considered, and a graft survival which is 14% less at 12 months and 40% less at 36 months (p = 0.0009). These differences are most probably to be attributed to the changes caused in these organs by advancing age and by previous pathological situations, as we have not detected a higher incidence of immunologic or surgical complications.

Age Factors↗
PubMed2000

[Experience with kidney transplantation with children as donors].

OBJECTIVE: To analyze the results achieved with transplantation of children kidneys to adult recipients. METHODS: The results achieved with transplantation of children cadaver kidneys (< 15 years) from 1989 to 1994 over a follow-up period of at least 36 months were reviewed. Patients (n = 43) were stratified into group A (13 grafts from donors < or = 6 years), group B (30 grafts from donors > 6 years) and group C (control group), which comprised 73 patients who received grafts from donors of an ideal age during the same time period. All three groups were similar for variables considered to influence the results of transplantation, except for the higher incidence of hypotension in group B. RESULTS: The number of episodes of rejection was three-fold higher in group A than in the control group (p = 0.019). A higher incidence of surgical complications, principally vascular complications (arterial thrombosis, renal rotation), was found in group A versus the control group (p = 0.039). When the grafts transplanted en bloc from donors under 12 months were excluded from the analysis, the incidence of vascular or urological surgical complications in group A was not found to be higher than that of the control group. No difference was found for mean length of stay, renal function (creatininemia), graft or patient survival for the three groups. CONCLUSIONS: Grafts from donors more than 6 years old showed a similar behavior as those from donors of an ideal age. Furthermore, single kidneys from donors aged more than 12 months can be transplanted with excellent results. It is necessary to have a larger series to confirm and explain the high incidence of acute rejection in grafts from donors less than 6 years old.

Adolescent↗
PubMed1996

[Renal transplantectomy].

OBJECTIVES: Renal transplantation is currently the treatment of choice for most of the cases with end-stage renal failure. However, approximately 35% present failure of graft function within 5 years post-transplantation. The need for graft removal, which is infrequently discussed in the literature, and the surgical technique employed are discussed. METHODS: From September, 1976 to December, 1994, we have performed 877 renal transplants; of these, 145 (16.5%) required removal. The literature is reviewed, with special reference to the indications for graft removal and the different surgical techniques employed. RESULTS: Our data show that 42% of non-functioning renal transplants required removal at some time. No complications arising from conservative management were observed in the remaining 58%. Graft failure due to acute or early acute rejection invariably necessitated removal; thereafter transplant nephrectomy was uncommon. There were no deaths from failed grafts maintained in situ in this series. CONCLUSIONS: Like other authors, our approach is to leave the graft in situ with or without low doses of corticosteroids. Transplant nephrectomy is reserved for the symptomatic cases. For cases requiring nephrectomy less than three months post-transplantation, we utilize the extracapsular approach; thereafter we utilize the subcapsular technique.

Blood Loss, Surgical↗
PubMed1994

[Complications of varicocele embolization: adhesion of the intravascular catheter during infusion of bucrylate].

The introduction of percutaneous occlusion techniques to manage a varicocele has made possible the control of the process with success rates similar to those obtained with conventional surgery. Its efficacy and minimal invasive nature, although not entirely risk-free, are responsible for its expansion. Contribution of one case of adhesion of the intravascular catheter to the underlying spermatic vein wall during infusion with isobutyl cyanoacrylate (bucrylate) as embolization material, an event which forced immediate surgical removal.

Adult↗
PubMed1994

[Hydatid cyst and renal adenocarcinoma: an exceptional association].

Presentation of one case of an exceptional association in the same renal unit of a hydatid cyst and an adenocarcinoma, in a female patient who arrived to the emergency service with a picture of haematuria and lower back pain. The paper discusses the diagnostic complications posed by the large central necrotic component of the tumour, the adjacent position of both lesions and, basically, the initial intention of performing conservative surgery after it was demonstrated that the patient had mild renal insufficiency and simple cysts in the other kidney. In the end, faced with the perioperative finding of a neoplastic-like mass, radical surgery was performed. Analysis of the diagnostic and therapeutical difficulties with complex cystic masses in general.

Adenocarcinoma↗
PubMed1993

[Abdominal paragangliomas. The experience of the Hospital 12 de Octubre].

This is a revision of our experience between 1975 and 1992 over a total of 35 patients who underwent surgery in 40 occasions for pheochromocytoma. If we dismiss one case of pheochromocytoma with early metastatic malignant presentation and which was not removed, a total of 6 patients with abdominal paraganglioma (17%) have undergone surgery in 10 occasions. Three of them (50%) were multiple and recurrent, an one (16%) become malignant after multiple recurrences. Average age was 34.6 years with balanced sex distribution. No patient had neurofibromatosis, Von Hippel Lindau disease, MEN syndromes or Carney's triad and only one case, which corresponded to the malignant pheochromocytoma, showed direct familial background. All patients were hypertensive. Four cases (66%) presented with catecholamine crisis, one case was an incidentaloma that at the 24-hour monitoring presented hypertensive crisis during the sleep, and the last one was diagnosed while investigating a case of sustained HTA in a young female. All patients had high urinary catecholamine excretion. To establish location of the tumour MIBG scanning (90% sensitivity) was used in first place followed by guided CT (80% sensitivity) since both techniques have a good correlation in order to design the surgical approach. Angiography was reserved for cases where the other two techniques were inconclusive or when it was necessary to obtain a better profile of the surgical anatomy. A total of 15 paraganglioma were removed, the most frequent location being renal parahilar (26%) followed by preaortic in Zuckerkandl's organ (20%) and vesical (20%). The most relevant intraoperative complications were HTA crisis related to anaesthetics manoeuvres and tumoral handling (90%), and hypotension following tumour exercises (10%). During the postoperative period, three patients required blood transfusion and one of them had to be re-intervened for bleeding caused by unnoticed damage to the right renal vein. Currently, three patients (50%) are disease free, one with residual mild HTA controlled with diuretics. Two patients (33%) are awaiting for re-intervention due to recurrence (one with multiple extra-abdominal recurrence) after one and two prior interventions respectively. The last one (16%) is the malignant pheochromocytoma, operated four times for recurrence which currently shows lung metastasis with adequate drug control of clinical manifestations, after polychemotherapy failure and 27-months follow-up since metastasis has been detected. Revision of existing literature and discussion of issues related to signs and symptoms, diagnosis, surgical preparation and approach, as well as prognostic implications related to paraganglioma as compared with adrenal-located pheochromocytoma.

Abdominal Neoplasms↗
PubMed1993

[Renal cystic carcinoma: report of five cases].

Of 204 renal adenocarcinomas seen in the Urology Service at the Hospital "12 de Octubre", from January 1974 to December 1992, we found five cases (2.5%) of cystic renal carcinoma in patients with an average age of 51.8 years (range 35-69), with a female vs male ratio of 3:2, and a right-sided vs left sided ratio of 4:1. The article describes the signs and symptoms, diagnostic methods used, treatment and subsequent evolution of our series, and includes a revision of the published literature.

Adult↗
PubMed1993

[Intradiverticular bladder tumors].

Retrospective study conducted on 58 patients with vesical diverticulum seen in our unit between 1975 and 1992, of which a total of 11 (18.9%) patients had vesical tumours. Of these, 6 (10.3%) were intradiverticular and 5 (8.6%) extradiverticular. Sixty-six percent of patients with intradiverticular tumours also had prior or concurrent history of extradiverticular vesical tumours. The most frequent clinical presentation was gross haematuria. The abdomino-pelvic CT is the most sensitive morphological examination although in 33% cases it resulted in overstaging. Curative treatment was only possible in the 4 patients with urothelial tumours, in whom 3 partial cystectomies with pelvian lymphadenectomy (2 pT1 G2 and 1 pT3 G3) and 1 TUR (T1 G2) were performed. The 2 (33%) remaining patients had advanced locoregional epidermoid carcinoma (T4 N+). All patients with urothelial carcinoma are alive with follow-up ranging between 6 months for the one infiltrant case and 136 months for a surface tumour undergoing partial cystectomy. Prognosis for both epidermoid carcinoma was ominous with mean survival time of 9 months. Review of the literature and discussion of epidemiological, clinical, diagnostic, therapeutic and prognostic issues.

Aged↗
PubMed1993

[Incidental renal adenocarcinoma: study on 54 cases].

Between 1974 and 1992, both inclusive, 204 renal adenocarcinomas were treated in the Urology Unit of the '12 de Octubre' Hospital, of which 54 (26.4%) were diagnosed by chance. The relative frequency of these renal tumours has experienced a highly significant progressive increase, from 0 in the 1974-1978 interval, to 13.04% in 1978-1980, 14.7% between 1981-1983, 20.68% in 1984-1986, 37.84% in 1987-1990, to reach over the last three-year period of 1990-1992 the remarkable figure of 41.93%. There has been no differences regarding incidence by sex (50% males and 50% females). Mean age at presentation is 61.5 years, ranging from 23 to 78 years. The suspected pathological cause most frequently leading to carry out the study where renal carcinoma is accidentally diagnosed are gastrointestinal disorders (50% of cases). The most frequently used imaging diagnostic technique is ultrasound (50% cases), emphasising the gradual increase in the number of cases diagnosed by ultrasound or CAT during the course of the study. Carcinomas accidentally diagnosed by CAT are those with less volume in our series. Regarding tumour characteristics, it should be pointed out a higher occurrence in the right kidney (64.8%) and a most frequent location in the upper renal pole (48%). Mean tumoral volume was 126 cc, although that value has gradually dropped, so that now the mean volume of accidental tumours treated over the last 5 is being 91 cc. Most cases present low staging at the time of diagnosis, 81% being pT2 N0 M0. Current overall survival is 89% of all cases followed-up.

Adenocarcinoma↗
PubMed1993

[Tumors of the female urethra: presentation of cases and review of the literature].

Female urethra tumours are rare conditions and so the series presented in the literature gathers just a few cases, and therefore is difficult to reach a conclusion with regard to the definite treatment to be adopted in each case. It appears to be certain that even histologically malignant forms of this disease can be cured in the earlier stages. The most representative cases presented in our experience are analyzed and an overall review of the literature is made aiming to examine the experience of various authors with regard to the diagnosis and treatment of the injuries.

Adenocarcinoma↗
PubMed1992

[Therapeutic options in metastatic renal carcinoma].

Within the scope of urogenital tract tumoral diseases, renal adenocarcinoma is the third most frequent neoplasia diagnosed in the adult population. The limited clinical presentations in early analysis and their anarchical behaviour are the cause for 50% to 60% of patients having already developed distant disease at the time of diagnosis. The only curative procedure so far is radical surgery, which is possible when there is a single metastatic site and sometimes even, depending on various factors which will be analyzed, several sites. In these occasions, the traditional therapeutic choices (Hormonotherapy, Chemotherapy, Radiotherapy) have proven to have limited or no efficacy in managing the disease. This fact, together with the successful results obtained in other tumoral processes, have allowed the clinical development of different modalities of Immunotherapy for the management of metastatic renal carcinoma, with results clearly hopeful. This work is a review of the results reported for each of the mentioned therapeutic choices, basically analyzing the role currently played by surgery and immunotherapy in the management of advanced renal carcinoma.

Combined Modality Therapy↗
PubMed1992

[Extrinsic stenosis of the ureter. Our caseload and review of the literature].

Obstructive uropathy is the common presentation course for various processes with an origin either intraluminar, parietal or extraluminar. A retrospective analysis of 41 cases of extrinsically originated obstructive uropathy seen in our Urology Unit from 1976 to 1991 was carried out. The cases were divided in three groups following an exclusively etiological criterion: 21.9% (9 patients) corresponded to primary retroperitoneal fibrosis; 51.2% (21 patients) to tumoral ureteral obstruction; and 26.8% (11 patients) to non-tumoral processes. For each division established, the features of clinical presentation, performance of the various diagnostic procedures used, and different therapy approaches are described also including a review on the current literature.

Adult↗
PubMed1992

[Priapism caused by cauda equina compression. Report of a case and review of the literature].

As a result from the mechanical irritation provoked on the sacral roots, the cauda equina compression syndrome can involve, as part of its symptomatic state, involuntary erections and mictional disorders which arise when standing and stretching the spine. In the eight cases of priapism from this cause reported in the international literature, surgical decompression has solved the clinical picture. We now present a new case with the peculiarity that, following unsuccessful surgical therapy, the infiltration of the compromised spinal roots has rendered excellent results.

Aged↗