Biomedical subjects
Publications and source records attributed to T Foukal.
The presence of calcified plaques is one of the few unequivocal indications for surgery of Peyronie's disease. The mean size of plaques described in the literature is 1.5-2 cm whereby it may vary from 1 mm all along the penis. The authors treated successfully an unusually large calcified plaque 7 x 0.8 cm with excellent postoperative results--restoration of the patient's full sexual activity which was not possible before operation.
It was described a case of sudden death. Its cause found during the microscopical evaluation was the idiopathic granulomatous myocarditis.
Fine needle biopsy was performed in 48 patients suffering from X-ray detected osteolytic lesions, during two years. A representative sample was obtained in 38 of them (79.2 percent). Cytologic conclusions could be proved in 35 patients by histology or clinical finding of primary tumour (in cases with bone secondaries). Cytologic diagnosis was correct in 30 patients (87.7 per cent). Especially good results were found out in bone metastases, plasmacytomas, and Ewing's sarcomas. Fine needle biopsy is to be recommended as an integral part of complex diagnosis of bone tumours.
The assessed elevated catecholamine levels in the organism during substantial physical or mental stress lead to changes in the heart rate and to intensification of contractions. The demands of the heart muscle as regards increased oxygen supplies and are not met. This may have serious consequences for the patient. The authors wanted to find out therefore whether the beta-blocker celiprolol will be able to reduce the negative effect of large amounts of catecholamine in the organism and thus play a part in the prevention of myocardial damage. When celiprolol was administered half an hour before isoprenaline, the extent of necrosis caused by catecholamine was reduced. When administered half an hour after isoprenaline administration, the marked protective effect was no longer observed. The necroses in the heart muscle were similar as in animals given catecholamine only.
The authors describe the case of an 80-year-old woman with a plasmocytoma IgD-lambda, which developed into plasmocellular leukaemia. The laboratory finding reminded at first of chronic lymphatic leukaemia. The correct diagnosis was assisted by marked leucocytosis with the release of a major number of plasmatic cells into the peripheral blood stream. The finding was confirmed on the basis of sternal puncture, cytochemical examination, immunochemical examination of the blood and urine and X-ray of the skull. Treatment led to marked clinical and laboratory improvement. The patient died, however, from pneumonia three months after establishment of the diagnosis. Post-mortem examination revealed an extensive infiltration of many organs and a myelomatous kidney. The authors present some differential diagnostic reflections on plasmocellular leukaemia.
The authors investigated ultramicroscopically the intercellular connections in the myometrium of pregnant women. In a small group an increased frequency of these connections was observed in association with labour, but unrelated to the period of pregnancy. By measuring the electric resistance of the myometrium in vitro a lower electric resistance of the uterine musculature was recorded in women where uterine activity was under way. The authors assume that the increased presence of free connections reduces the electric resistance of tissue and makes more rapid spread of information in the myometrium possible. In the long run it is one of the factors which lead to spontaneous uterine activity.
A thyroid tumour in a 58 year-old woman was studied by light and electron microscopy and immunohistology. Initial diagnosis of anaplastic osteoclastoid carcinoma had to be changed to malignant fibrous histiocytoma. Histogenetical evaluation was discussed.
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Influence of Neo-Gilurytmal was studied upon catecholamine heart lesion in rats of two weight categories: In bigger ones (350-420 g) the lesion was diminished, in smaller animals (200-230 g) any protective influence did not occur. Sensitivity of myocardium to Neo-Gilurytmal is supposed to concur with that to catecholamine effect in rats of increasing weight.
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The authors summarize the morphological findings on cementoma-like fibromas of long bones registered at the Reference Centre for Bone Tumours in Brno or referred to it. One of the cases registered is described in detail from the submicroscopic point of view. Their experience has shown that cementoma-like fibromas of long bones are genuine bone tumours sui generis, differing to some extent from cementomas of the jaws. The cementicles in such tumours are identical to acellular dental cement and structurally quite different from osteoid.