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Biomedical subjects

T Foukal

Publications and source records attributed to T Foukal.

27 records · Page 2Linked to original sources
PubMed1979

[Cystic degeneration of adventitia].

A description is presented of the cystic degeneration of the adventitia of the external iliac and femoral arteries. Numerous cysts in the adventitia compressed the arterial lumen and resulted in thrombotic occlusion. The histologic picture was similar to that of tendinous sheath ganglion. A list is given of cases already described with a discussion of the views concerning its aetiology and pathogenesis.

Cysts↗
PubMed1979

Histologic changes in the human skin melanoma after intratumorous treatment with BCG.

Twenty six patients with malignant skin melanomas were treated with an intratumorous injection of 0.1 ml BCG applicated in certain time intervals. Histologic changes in tumor tissue starting with dystrophy and necrosis of the cells and ending with the formation of a granular tissue replacing the tumor are described. In one case the untreated satellite localized 2 cm from the injected tumor disappeared. The results indicate that the reaction of the cells on the applicated vaccine varied. In some tumors dystrophic changes and necroses were very large, in others they were of a lesser extent, but in all the process ended with the formation of a granular tissue. The mechanism of the action of BCG is discussed. For the time being, it seems that the intratumorous application of BCG is a useful adjuvant therapy.

BCG Vaccine↗
PubMedDate not supplied

Influence of physical exertion on early isoproterenol-induced heart injury.

The effect of swimming instantly following an injection of isoproterenol was studied in rats in whom the administration of the drug caused changes in the cardiac muscle. The animals were compared with those of a group kept only under normal cage activity after the administration. Oxygen inhalation in the exercised group of rats was higher than in the sedentary group and after 4 minutes of measuring, continually remained at a higher level. It was determined that swimming prevented the early death of the rats. This was more pronounced in the animals of higher body weight. The extent of myocardial damage in the exercised group was markedly smaller. The intensity of enzyme reaction, SDH, LDH and G6PDH, in the area of undamaged tissue was the same in both the exercised and sedentary groups, in areas of damage it was minimal. The intensity of alpha GP was lowered in the exercised group, but in the sedentary group it was lowered throughout the entire section. Electron optic examination of the tissue, which under the light microscope appeared normal, revealed no substantial differences between the exercised and sedentary groups. We presume that the better condition of the rats was in part due to the peripheral breakdown of the catecholamine owing to the increased blood flow created by muscular activity.

Animals↗