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Biomedical subjects

T Fujitani

Publications and source records attributed to T Fujitani.

At least 73 records · Page 4Linked to original sources
PubMed1983

Malignant lymphoma presenting as a parotid mass.

Primary malignant lymphomas of the salivary glands are very rare. Three cases of diffuse B-cell malignant lymphomas, each developing as a parotid mass, were presented. The preoperative early diagnosis is essential in these cases to avoid an unnecessary radical procedure as well as to have a beneficial effect on the prognosis. If there were a possibility of malignant lymphoma, present authors stressed that an incisional biopsy should be performed for diagnosis. The usefulness of immunopathological diagnosis of these tumors has been discussed with regards to the prognosis.

Aged↗
PubMed1981

Clinical and prognostic significance of the T-B immunological classification of non-Hodgkin's lymphomas.

This study was made to test the clinical significance and the prognostic value of the T-B immunological classification of non-Hodgkin's lymphomas. Thirty-four patients with adult diffuse lymphomas were studied. Nine patients with T-cell lymphomas and three patients with non-T and non-B lymphomas had poor immunity and poor prognosis. Fifteen patients with B-cell lymphomas have been found to be associated with a prognosis of intermediate range between that of T-cell lymphomas and undetermined lymphomas. Seven patients with undetermined lymphomas, which were considered to have lost surface markers of B-cells, had the best prognosis. Thus the T-B immunological classification of this disorder appears to be essential for clinicians, and provides a basis for proper differentiation of treatment for different groups.

Adult↗
PubMed1978

Extramedullary plasmacytoma of the oropharynx producing kappa-type Bence-Jonas protein.

A case of extramedullary plasmacytoma in the oropharynx of a 41 year-old woman is reported. Histologically, the tumor was plasmacytoma consisting mainly of matured plasma cells and showing a deposit of amyloid in the interstitial structure. Immunoelectrophoretic studies of the concentrated urine specimen revealed a kappa-type Bence-Jones protein even though there was no increase in blood M-protein. Lineac electron radiation of 5,100 rad was given over a period of eight weeks but no effect was noted. After the tumor was surgically removed, follow up of the patient was made for 2 years without evidence of recurrence or metastasis.

Adult↗
PubMedDate not supplied

Thiabendazole (TBZ) nephrotoxicity and recovery in ICR adult mice.

The nephrotoxicity and recovery following administration of thiabendazole (TBZ) were investigated in ICR adult mice. A single oral administration of TBZ (500-2000 mg/kg body wt.) caused a dose-dependent proximal tubular necrosis in the kidney and increase in serum urea nitrogen 24 h after dosing. These changes were marked in mice of high dose groups (1000 or 2000 mg TBZ/kg body wt.). The time course of changes on kidney of mice treated with 1000 or 2000 mg TBZ/kg body weight were examined at 1, 2, 3, 5, 7 or 10 days after dosing. Light microscopy showed necrosis of proximal convoluted tubules from 1 day after dosing. Tubular necrosis was extensive 2 or 3 days after dosing. Partial regeneration from tubular necrosis was seen 3 days after dosing, and substantial regeneration had occurred from 5 days after dosing. Thus, TBZ-induced renal injury was most severe at 2 or 3 days after dosing and was followed by regeneration. Electron microscopy showed swelling of mitochondria in the proximal tubular epithelium at 1 day after dosing. The pathological changes were correlated with the changes in urinalysis, serum urea nitrogen concentration and kidney weight.

Administration, Oral↗
PubMedDate not supplied

Effects of thiabendazole (TBZ) on mitochondrial function in renal cortex of ICR mice.

The effects of thiabendazole (TBZ) on mitochondrial function of the renal cortex were investigated in ICR mice. Mice were given 1000 or 2000 mg TBZ/kg body weight by gavage and mitochondria were isolated from the renal cortex for the measurement of respiratory rates. The state 3 and DNP-uncoupled respiratory rates of renal cortical mitochondria were dose-dependently depressed at 6 hours after dosing. The depression of these respiratory rates of renal cortical mitochondria was more marked at 16 hours after dosing. There was no depression in these respiratory rates of renal cortical mitochondria at 3 hours after dosing, although renal cortical concentrations of TBZ were higher than those at 6 or 16 hours after dosing. Histochemical examination revealed that NAD-linked isocitrate dehydrogenase, a marker enzyme of mitochondria, was inhibited in renal cortical tubules at 16 hours after dosing of 1000 or 2000 mg TBZ/kg body weight. Furthermore, renal cortical ATP level was significantly decreased at 16 hours after dosing of 1000 or 2000 mg TBZ/kg body weight. The results indicate that administration of TBZ caused mitochondrial dysfunction in renal cortical tubules of mice.

Adenosine Triphosphate↗
PubMedDate not supplied

Developmental toxicity of chlorpropham in mice.

The present studies were designed to evaluate the developmental toxicity of chlorpropham in mice. The first study was conducted to determine administration time, and the second study was designed to evaluate dose-response effects. Chlorpropham was administered to pregnant mice by gavage on Days 8, 8.3, 9, 9.3, 10, and 11 of gestation at a level of 3000 mg/kg bw, and the females were killed on Day 18 of gestation. The administration on Day 8.3 of gestation induced the highest percentage of external malformations with brachyury occurring among more litters than in other groups. Chlorpropham was administered to pregnant mice by gavage at a level of 0 (control), 750, 1500, and 3000 mg/kg bw on Day 8.3 of gestation, and the females were killed on Day 18 of gestation. The total resorption rate was significantly increased in the 3000 mg/kg bw group. The average fetal body weight of each sex was significantly reduced in the 3000 mg/kg treatment group. The total incidence of external malformations was significantly increased in the two highest dose groups in a dose-related manner. Again brachyury was significantly increased in the 3000 mg/kg bw group.

Abnormalities, Drug-Induced↗