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Biomedical subjects

T GUTHE

Publications and source records attributed to T GUTHE.

At least 19 recordsLinked to original sources
PubMed1963

THE FREQUENCY OF VENEREAL DISEASE AMONG SEAFARERS.

Venereal diseases are known to occur most frequently in the age-groups of greatest sexual activity and more frequently among people in certain occupations (e.g., migrant labourers, military personnel and seafarers) than among the general population. The Brussels Agreement of 1924 and the great improvements in conditions of life at sea and facilities in ports for seafarers since the First World War raised hopes that venereal diseases would be brought under control. The discovery of penicillin and the simplification of the treatment of gonorrhoea and syphilis by its use increased this optimism. Studies undertaken between the two world wars and more recently indicate, however, that the rates of venereal diseases among seafarers continue to be considerably higher than those among the general population in the countries studied. Of particular interest are several studies concerning the treatment of suspected venereal disease on board ships not carrying a doctor. Stricter observance of the revised International Agreement of Brussels and of the minimum requirements for the training of personnel and the equipment in ports and on board ships is considered necessary.

Chlortetracycline↗
PubMed1961

Failure to control gonorrhoea.

There is increasing evidence of emerging resistance of the gonococcus to antibiotics, particularly penicillin, but apparent resistance may sometimes be due to concomitant infection with micro-organisms other than the gonococcus, which are not susceptible to this antibiotic. There is also evidence that clinical complications, particularly in the female, are much more frequent than was previously believed to be the case. The incidence of gonorrhoea has increased significantly in many countries in spite of the availability of the "ideal" drug, penicillin. The reasons for the failure to control gonorrhoea in the individual and in the mass of patients are discussed, taking into account a number of factors relating to emerging drug resistance of the gonococcus, insufficient criteria for diagnosis, the possibility of persistence of infection and increased frequency of reinfection.

Anti-Bacterial Agents↗
PubMed1958

Prevention of venereal infections.

In the first part of this paper, a plea is made for a broad view by health administrations of the preventive aspects of venereal disease control, based on epidemiological rather than purely clinical grounds. Stress is laid on the importance of measures directed towards health promotion, specific protection, early recognition and prompt treatment, disability limitation, and rehabilitation. The value of case-finding and contact-tracing and of systematic blood-testing of certain population groups is emphasized.In the second part, measures for local and systemic prophylaxis are discussed. It is also pointed out that in the past 15 years there has been a rapid reduction in syphilis throughout the world as a whole (although some recrudescence has recently been reported in certain countries), but that over the same period the reservoir of gonorrhoea has been but slightly reduced. The possible epidemiological, immunological and other reasons for this phenomenon are gone into, and the conclusion is reached that the outlook for the control of gonorrhoea is now somewhat less favourable than it was a few years ago. Should apprehension on this score bring about a general orientation away from penicillin (particularly the long-acting preparations) in treating gonorrhoea, the effect on the reservoir of syphilis may also be unfortunate.

Humans↗
PubMed1958

Untoward penicillin reactions.

The literature on untoward reactions following the administration of penicillin is reviewed. These reactions, including a certain number of deaths which have been reported, are of particular interest to health administrations and to WHO in view of the large-scale programmes for controlling the treponematoses which are now under way-programmes affecting millions of people in many parts of the world.The most serious problems are anaphylactic sensitivity phenomena and superinfection or cross-infection with penicillin-resistant organisms, and the reactions involved range in intensity from the mildest to the fatal; the incidence of the latter is estimated at 0.1-0.3 per million injections. The authors point out that with increasing use of penicillin, more persons are likely to become sensitized and the number of reactions can therefore be expected to rise. The best prevention against such an increase is the restriction of the unnecessary use of penicillin.

Humans↗