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Biomedical subjects

T Ino

Publications and source records attributed to T Ino.

At least 307 records · Page 17Linked to original sources
PubMed1983

Recent results and problems in the surgical treatment of acquired valvular heart disease.

From June, 1977 to August, 1981, 388 patients underwent open heart surgery for acquired valvular heart diseases. The over-all surgical mortality rate during this period was only 4%, but a high incidence of postoperative complications (26% for major complications) was still observed. It is an urgent concern for all cardiac-surgeons to reduce postoperative complications in order to obtain better surgical results. Even with improved techniques in modern cardiac surgery, 28 patients with a giant left atrium were still in the high risk group, with an over-all mortality rate of 29% and with a high incidence (68%) of postoperative complications. This seemed to be attributable mainly to deteriorated conditions such as cardiac cachexia, but not necessarily to impaired pulmonary function. Therefore, more careful considerations should be paid not only for their circulatory and pulmonary conditions, but also for the improvement of their general condition, including nutrition and metabolism. On the other hand, 27 patients with infective endocarditis showed a remarkable improvement after prosthetic valve replacement in spite of their seriously deteriorated preoperative condition. There were 4 hospital deaths (15% mortality). All transferred to our institution in a far advanced stage of the disease. Early surgical intervention for intractable cardiac failure should be strongly recommended for these patients.

Adolescent↗
PubMed1983

[Two-dimensional echocardiographic observation of a rapidly growing floating left atrial ball thrombus: report of a case with mitral stenosis].

This report dealt with a rapidly growing ball thrombus floating in the left atrium in a case with mitral stenosis detected by serial two-dimensional echocardiography and confirmed at operation. A 45-year-old female was admitted to our hospital on January 7, 1982 because of dyspnea, orthopnea and fever. On admission she had typical auscultatory signs of mitral stenosis, and her chest roentgenogram revealed slight pulmonary venous congestion and marked left atrial enlargement. Laboratory findings including complete blood counts, coagulation studies and blood chemistry were normal except a positive CRP test. Two-dimensional echocardiography performed on January 8 revealed a tight mitral stenosis with the mitral orifice area of about 0.9 cm2, and a floating ball thrombus in the left atrium, which was 2.5 X 3 cm in size. Fuzzy echoes flowing slowly around the thrombus were also observed. Intravenous administration of heparin was started immediately. In the next morning (January 9), the two-dimensional echocardiography was reexamined, which revealed a markedly growing thrombus which became 4 X 4 cm in size. Several hours after the reexamination mitral valve replacement was performed. The removed thrombus was 5.5 X 7 cm in size and consisted of three laminated structures. This finding was consistent with the echocardiographic observations. Coagulation studies made just before operation showed increased coagulability. Increased stagnation of blood in the left atrium due to heart failure and a transient increase of blood cell aggregation and coagulability induced by preceding infection might be responsible for the genesis of such a thrombus.

Echocardiography↗
PubMed1982

Etiology of mitral regurgitation in secundum atrial septal defect.

Non-rheumatic mitral regurgitation was found in 9.1% (27 patients) of all patients with secundum atrial septal defect (298 patients) who were operated on during a 13-year period at the Mitsui Memorial Hospital. This combined lesion was more frequent in female (12.3%, 19 patients) than male (5.6%, 8 patients), and the incidence tended to increase with age. Inspection at operation revealed a marked fibrous thickening of the anterior and posterior mitral valve leaflets with a localized bulging into the left atrium in the posteromedial commissural area. Similar, but less prominent change was found in nearly all patients above 20 years of age with mitral regurgitation, although the small area where the commissural chordae were attached was not involved. A friction between anterior and posterior mitral leaflets due to abnormal left ventricular motion secondary to the right ventricular volume overload might be responsible to the genesis of this lesion. Mitral annuloplasty was performed on 21 of 27 patients with a satisfactory result without operative mortality. Except one case of early death from cerebral thromboembolism they were all restored to a functional status of class I by NYHA standard within one year after operation, and there were no late death during a follow-up period of as long as 12 years. We propose a new entity "ASD, MR complex" for this combined lesion, as it demonstrates a specific pathophysiology, and necessitates a different procedure for surgical correction from that of a secundum atrial septal defect without other anomalies.

Adolescent↗
PubMed1982

Electrocochleographic study of summating potentials in Menière's disease.

(1) The polarity of summating potentials (SP) and the SP/AP ratio in Menière's disease depend on the electrode position in the tympanic cavity, on the interval between sound stimuli and the method of recording, whether it is by transtympanic or extratympanic recording. (2) In a series of 42 patients with unilateral Menière's disease abnormal SPs were not very closely related to the time elapsed since the onset of vertigo, audiometric pattern, or the results of the glycerol test. (3) It was not possible to differentiate Menière's disease from sudden deafness on the basis of large SP/AP ratios alone. Such ratios were found frequently in both diseases. (4) Recovery or progression of hearing impairment was not always related to changes in the SP. (5) Positive SPs were seen more often in Menière's disease than in other types of sensorineural hearing loss.

Action Potentials↗
PubMed1982

Experimental studies on vertical infection of mice with Japanese encephalitis virus III. Effect of gestation days at the time of inoculation on placental and fetal infection.

An experiment was carried out on the effect of gestation days at the time of inoculation on the establishment of experimental vertical infection with Japanese encephalitis virus in mice. In it, mice of the CFW strain in a closed colony were inoculated intravenously with a field strain at different times over a period from 3 to 12 days of gestation. After that, an attempt was made to recover the virus from the placenta and fetus to estimate the rate of infection. As a result, placental infection was established not when the virus was inoculated at 3 days of gestation, but when it was inoculated at 4 days of gestation or later. The rate of infection was relatively high when the virus was inoculated at 6 days of gestation or later. Fetal infection was established relatively frequently when the virus was inoculated some time between 7 and 10 days of gestation, but quite infrequently when the virus was inoculated at any other time than this. There was a difference in rate between placental and fetal infection at a given time of inoculation in days of gestation. This difference seemed to have been induced not by a difference in intensity of viremia appearing after inoculation, but by a difference in degree of development between placental and fetal tissues at the time of inoculation.

Animals↗