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Biomedical subjects

T Ise

Publications and source records attributed to T Ise.

At least 91 records · Page 5Linked to original sources
PubMed1975

Bronchial hypersensitivity to methacholine in monkeys with beta-adrenergic blockade.

In monkeys with beta-adrenergic blockade caused by administration of propranolol, we found that the conductance of the total respiratory system markedly decreased following intravenous administration of methacholine. The presence of beta-adrenergic blockade was judged from inotropic effect on the heart, levels of blood glucose and lactic acid, and the reaction of eosinophils after adrenalin injection.

Animals↗
PubMed1975

Effects of beta-adrenergic stimulating and blocking agents on the adrenaline response and adenyl cyclase activity of leukocyte in monkey and human being.

Using the method in which leukocyte suspensions were incubated with NaF or metaproterenol at 30 degrees C for 15-30 min to allow them to convert 3H-ATP (10 muCi) to 3H-cyclic AMP, followed by separation of the formed 3H-cyclic AMP by common chromatography, the leukocyte adenyl cyclase activity of monkeys and human beings was measured with high reproducibility. The oral administration of metaproterenol increased the leukocyte adenyl cyclase activity which was stimulated by NaF and decreased the count of peripheral eosinophils in some of the monkeys. In the beta-adrenergic blockade of the monkey which was made by administration of propranolol, the leukocyte adenyl cyclase activity significantly decreased. The leukocyte adenyl cyclase from patients with coronary heart disease also decreased after oral medication with propranolol.

Adenylyl Cyclases↗
PubMed1975

Leukocyte adenyl cyclase activity in human bronchial asthma.

Changes in adenyl cyclase activity of the peripheral blood leukocytes were investigated in patients with bronchial asthma. Estimation of the leukocyte adenyl cyclase activity was carried out following in vitro stimulation by sodium fluoride (NaF) or metaproternol. The NaF-stimulated adenyl cyclase activity was significantly lower during asthmatic attacks. An oral administration of metaproterenol to patients during an attack was found to enhance the activity back to the control levels. Off-attack asthmatic patients showed a normal value which was again elevated considerably when they were administered metaproterenol. In contrast, measurements of adenyl cyclase activity using metaproterenol stimulation showed little change in patients in spite of asthmatic attacks or metaproterenol regimen. The lowering of the NaF-stimulated leukocyte adenyl cyclase activity was inversely proportional to the degree of lymphopenia during attacks and positively correlated with an increasing percentage of neutrophils.

Adenylyl Cyclases↗
PubMed1975

A study of western red cedar-induced asthma.

Seventeen asthmatic patients who were workers dealing with Western Red Cedar in a Japanese wooden frame factory were studied. One fraction from the aqueous extract of the lumber induced a positive skin test, Prausnitz-Kustner test and the inhalation test. This confirms the existence of antigen in Western Red Cedar and its ability to produce allergic asthma in sensitive workers.

Acetylcholine↗
PubMed1975

A study of Western Red Cedar sensitivity: workers' allergy reactions and symptoms.

In 154 individuals who work with Western Red Cedar in Japanese wooden frame factories a high incidence (24.7%) of bronchial asthma was observed. A positive intradermal test was found in 89% of the asthmatics and in 56% of all. A highly positive inhalation test was obtained only in the asthmatic group. It is suggested that other symptoms in addition to bronchial asthma might be caused by Western Red Cedar because of the frequency of positive skin reactions to the Western Red Cedar antigen.

Asthma↗