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Biomedical subjects

T Iversen

Publications and source records attributed to T Iversen.

At least 73 records · Page 4Linked to original sources
PubMed1982

Pelvic lymphoscintigraphy with 99mTc-colloid in lymph node metastases.

Twenty-four patients with cervical cancer stage Ib were examined by pelvic lymphoscintigraphy with 99mTc-colloid prior to operation. Four of the patients had histologically verified lymph node metastases. No difference in the lymphoscintigrams was found between the patients with pelvic metastases and those without. The removed involved lymph nodes did not contain less radioactive colloid than the histologically normal nodes. In two involved lymph nodes the uptake of radioactivity was far above any of the noninvolved nodes.

Adult↗
PubMed1982

X-linked congenital adrenal hypoplasia. A study of five generations of a Greenlandic Family.

In a Greenlandic family comprising 171 descendants in 5 generations, 11 boys had died with a clinical picture of adrenocortical insufficiency within three weeks of birth. Three treated male patients, who survived, were closely studied. The adrenal glands could not be identified by computed tomography. The clinical picture and biochemical studies were consistent with congenital adrenal hypoplasia. The pedigree indicates X-linked recessive inheritance. The pubertal development was delayed in two patients aged 14 years. LHRH stimulation yielded a significant rise in LH and FSH in at least one of the patients, adrenal androgen values were very low. A family instruction programme has been set up.

Adolescent↗
PubMed1982

Irradiation and bleomycin in the treatment of inoperable vulval carcinoma.

Fifteen patients with inoperable squamous cell carcinoma of the vulva were treated with Bleomycin and irradiation. Only 2 patients were also treated with vulvectomy and bilateral lymphadenectomy 2 weeks later. One patients survived more than 4 years without signs of recurrence, another survived 2 1/2 years and 2 more 18 and 12 months respectively. The rest died less than 6 months after the treatment. Three patients developed signs of lung fibrosis. Bleomycin and irradiation may render a tumor operable, but in most cases this regime merely aims at palliation.

Aged↗
PubMed1982

Stage IB carcinoma of the cervix, the Norwegian Radium hospital. II. Results when pelvic nodes are involved.

From 1967 through 1972, 562 patients with squamous cell carcinoma of the cervix, stage IB (FIGO), underwent radical hysterectomy with pelvic lymphadenectomy. The patients with pelvic metastases were treated with external beam supervoltage irradiation of 4000 or 5000 rads to the pelvis. Metastases in the pelvic lymph nodes were found in 21.3%. In this study the authors analyzed in detail which nodes were involved with metastases and the relationship with survival and with recurrence. The overall 5-year survival for patients with pelvic lymph node metastases was 53%; for patients without metastases it was 92%. The site of recurrence in patients without demonstrable pelvic lymph node metastases was also examined. The main conclusion drawn from the study is that patients with pelvic node metastases below the common iliac group have a much better prognosis than patients in whom metastases are located in the common iliac nodes; in addition, when nodal involvement is below the common iliac level, patients with disease limited to one node or one group of nodes do not have a better prognosis than patients with multiple metastatic nodes.

Carcinoma, Squamous Cell↗
PubMed1981

Radical surgery in stage I carcinoma of the corpus uteri.

Thirty-four patients with stage I adenocarcinoma of the corpus uteri were selected for radical hysterectomy combined with bilateral transperitoneal pelvic lymphadenectomy and followed 8 to 15 years. Metastases to the pelvic lymph nodes were diagnosed in 18%. Invasion of tumour in lymph or blood vessels was found in 17 patients, and five of these patients had lymph node metastases whereas this was true in only one out of 17 patients without demonstrable vessel invasion. The 5-year crude survival was 80% with 15% urinary tract complications.

Adenocarcinoma↗
PubMed1981

Squamous cell carcinoma of the vulva. Localization of the primary tumor and lymph node metastases.

A total of 154 patients with squamous cell carcinoma of the vulva stages II, III and IV treated with radical vulvectomy and bilateral inguinal lymphadenectomy, of whom 72 also underwent pelvic lymphadenectomy, have been followed-up for 3-21 years. Metastases from unilateral tumors were found in the lymph nodes on the same side. No other significant relationship between the localization of the primary tumor and lymph node mestastases was found. Pelvic lymphadenectomy seemed not to influence the prognosis.

Carcinoma, Squamous Cell↗
PubMed1981

Individualized treatment of stage I carcinoma of the vulva.

A series of 117 patients with stage I squamous cell carcinoma of the vulva was followed for 3 to 21 years. Twenty recurrences (17.1%) were found, 12 in the vulva or vagina, 7 in the groin, and 1 in a patient who developed distant metastases. Invasion of tumor cells in lymph or blood vessels was found in operative specimens from 19 patients (16.2%), 8 of whom (42.1%) developed local recurrences of metastases. Of 76 patients who underwent lymphadenectomy, 7 had ipsilateral and 1 had bilateral metastases to the inguinal lymph nodes. Five-year crude survival rate for the whole series was 79%, but only 52% for the group of patients with vessel invasion. Treatment should in most cases be hemivulvectomy with ipsilateral inguinal lymphadenectomy.

Female↗
PubMed1979

Factors influencing the treatment of patients with stage Ia carcinoma of the cervix.

A total of 122 patients with Stage Ia carcinoma of the cervix was followed for 5 to 25 years. Eight recurrences were found, four of which were located in the vagina, cervix or the bladder and four on the pelvic wall. Five of the recurrences were detected after 5 years of follow-up. Tumour cells were found in blood vessels or lymphatic channels in eight patients and five of them developed metastases. It is proposed that only tumours with a depth of stromal invasion of less than 5 mm should be treated conservatively. If blood vessels or lymphatic channels contain tumour, we would recommend a Wertheim's hysterectomy or treatment by intracavitary and external irradiation.

Adult↗
PubMed1979

Effect of irradiation on the feto-placental tissues.

Seven pregnant patients with genital carcinoma were treated with high voltage irradiation in combination with operation. Five patients aborted spontaneously after a dose of 30 to 34 Gy. Two were operated within 2 weeks after completed irradiation. Angiography, microscopy and hormone analyses indicate that damage of the fetal central nervous system and not placental insufficiency is responsible for the intrauterine fetal death.

Abortion, Therapeutic↗