PubMed Health⌕ Search

Biomedical subjects

T J Crow

Publications and source records attributed to T J Crow.

At least 415 records · Page 23Linked to original sources
PubMed1973

Impaired learning and decreased cortical norepinephrine after bilateral locus coeruleus lesions.

Bilateral lesions of the nucleus locus coeruleus in rats deplete the cerebral cortex of norepinephrine and significantly diminish the rate of increase of running for food reward in a simple L-shaped runway. As assessed in this situation, learning was absent in those rats with the most complete ablations of the locus coeruleus, although these rats showed normal weight gain and normal motor and exploratory activity.

Animals↗
PubMed1973

Behavioural studies of the actions of cocaine, monoamine oxidase inhibitors and iminodibenzyl compounds on central dopamine neurones.

1. Turning behaviour after unilateral lesions of the nigro-striatal dopamine pathway in rats has been used to compare the actions of cocaine and desipramine on central dopamine-containing neurones.2. Administration of cocaine alone (5-20 mg/kg) resulted in no turning or minimal turning towards the lesioned side; the monoamine oxidase inhibitors nialamide and pargyline administered alone were also ineffective.3. After pre-treatment with nialamide (100 mg/kg) or pargyline (25 mg/kg) cocaine evoked high rates of turning towards the lesioned side.4. Desipramine (1-100 mg/kg), either alone or in combination with nialamide did not evoke turning.5. Turning evoked by the cocaine-nialamide combination was abolished by pre-treatment with alpha-methyl-p-tyrosine (150 mg/kg).6. Pre-treatment with reserpine (5 mg/kg, 24 h previously) substantially diminished turning evoked by the cocaine-nialamide combination but potentiated turning resulting from administration of methylamphetamine (5 mg/kg).7. Cocaine (20 mg/kg) administered 15 min prior to (+)-methylamphetamine (5 mg/kg) reduced the turning behaviour in the first hour after administration of the latter drug but prolonged the total duration of the effect.

Amphetamine↗
PubMed1973

An analysis of the learning deficit following hyoscine administration to man.

1. Twelve volunteer subjects completed a free-recall word learning test, a number-colour association test, and a scanning task after the following treatments: saline 1 ml, hyoscine 0.4 mg, or atropine 0.6 mg, administered by intravenous injection.2. Performance on all three tests was not significantly impaired after atropine.3. Performance on the two learning tests but not on the scanning task, was significantly impaired after hyoscine.4. Analysis of the results of the free-recall word learning test indicates that impairment of learning following hyoscine does not affect recall over intervals of a few seconds, but affects that portion of the learning curve which has been attributed to long-term (or secondary) rather than short-term (or primary) memory.5. The results suggest that hyoscine 0.4 mg may impair learning processes, without significantly depressing other psychological functions, and that the impairment of learning following hyposcine does not affect recall over intervals memory.

Adult↗