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Biomedical subjects

T J Crow

Publications and source records attributed to T J Crow.

At least 433 records · Page 24Linked to original sources
PubMed1971

Turning behaviour as an index of the action of amphetamines and ephedrines on central dopamine-containing neurones.

1. Rats lesioned unilaterally in the substantia nigra show no obvious abnormalities after recovery from the operation but rotate towards the lesioned side after administration of drugs of the amphetamine and ephedrine groups.2. (+)-Amphetamine and (-)-amphetamine are equally potent in producing turning behaviour but (+)-methylamphetamine is considerably more effective.3. (-)-Ephedrine (with a beta-OH group on the ethylamine side chain) induces turning but only in doses approximately 20 times greater than (+)-methylamphetamine.4. (+)-Norpseudoephedrine was the most effective of the ephedrine isomers tested followed by (-)-ephedrine and (+)-pseudoephedrine.5. Turning produced by (-)-ephedrine and (+)-methylamphetamine is not reduced by FLA63 (50 mg/kg) 4 h previously, but is almost completely inhibited by alpha-methyl-p-tyrosine (150 mg/kg) 12 h previously.6. Reserpine pretreatment potentiates turning produced by (-)-ephedrine.7. Chlorpromazine (5 mg/kg) completely blocks turning induced by (+)-methylamphetamine although it concurrently increases exploratory activity. The level of exploratory activity after the (+)-methylamphetamine-chlorpromazine combination is more than 3 times that attained after saline alone.

Amphetamine↗
PubMed1970

Lack of coincidence between neural and behavioral manifestations of cortical spreading depression.

The presence of cortical spreading depression is typically inferred from the presence of hypesthesia. The electrocorticogram and slow-potential change were recorded during cortical spreading depression and it was found that hypesthesia remained long after the cortex recovered from neural depression. Hypesthesia, therefore, is an unreliable indicant of cortical spreading depression; if cortical spreading depression is used as a research tool, neural activity must be monitored. These data offer a special problem for memory transfer studies.

Animals↗