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Biomedical subjects

T Jennings

Publications and source records attributed to T Jennings.

26 records · Page 2Linked to original sources
PubMed1988

Posterior sub-Tenon's injections of corticosteroids in uveitis patients with cystoid macular edema.

Cystoid macular edema (CME) is a major cause of visual impairment and is thought to be due to abnormal perifoveal capillary permeability. Posterior sub-Tenon's corticosteroid injections are used to improve the visual acuity in CME, although their mechanism of action is uncertain. In this study, visual acuity, blood retinal barrier (BRB) permeability, and fluorescein angiograms were recorded immediately before and one and four weeks after the administration of steroid injections. Ten patients (12 treated eyes) with CME secondary to uveitis were studied. Visual improvement, defined as an increase in at least two lines of Snellen visual acuity, was seen in half of the treated eyes. In some patients, these improvements were not directly related to changes in the BRB permeability or the amount of macular fluid. Posterior sub-Tenon's corticosteroid injections do not consistently affect blood retinal barrier permeability.

Adolescent↗
PubMed1987

Study of neuromotor reaction times under the influence of thyrotropin-releasing hormone.

Neuromotor reaction times (simple, choice, and decision) were measured when Thyrotropin-releasing hormone (TRH) was administered intravenously to nine healthy men in a double-blind study. Measurements were made of simple reaction time, choice reaction time, and decision time for each subject at various intervals over a 54-hr. period. Given the observed inherent interaction of the drug with the long time used (54 hr.), most analyses were conducted across separate time epochs. Injected subjects showed inhibition in the normal improvement of simple reaction time (which occurs with practice), and they reduced the time required to make a decision. Choice reaction time, however, remained unchanged across the drug-nondrug experimental conditions.

Adult↗
PubMed1986

Effect of inspiratory volume on intrathoracic pressure generated by an L-1 maneuver.

Since each muscle has an optimal length at which it can generate the maximum tension, an optimal inspiratory volume may exist for producing the maximum intrathoracic pressure during the L-1 maneuver. Intrathoracic pressures were measured in eight healthy men after they inspired various volumes of air and performed the L-1 straining maneuver in a 1-G environment. Both the peak and mean intrathoracic pressures increased at greater inspiratory volumes, except for the mean intrathoracic pressure at the highest volumes. The ability to increase intrathoracic pressure with larger inspiratory volumes may improve +Gz tolerance.

Adult↗
PubMed1985

Effect of body inversion on hemodynamics determined by two-dimensional echocardiography.

The purpose of this study was to determine if head-down inversion of normal men from a supine position would increase blood return to the heart. Eight healthy, normovolemic men were placed into 10 degrees, 30 degrees, 60 degrees, and 90 degrees head-down tilt positions. BP and two-dimensional echocardiograms were recorded at the supine baseline and immediately after inversion. There was no significant change in left ventricular end-diastolic volume, stroke volume, cardiac output, or BP with inversion, except for a significant increase in diastolic pressure at the 60 degree position. The efficacy of placing hypotensive shock patients in the head-down tilt position is discussed.

Adult↗
PubMed1982

Completeness of infant death registration for very low birthweight infants: Washington State 1978-79.

Washington State hospitals were queried about the fate of 507 infants born in 1978-79 for whom no linked death certificate existed. Only ten previously unregistered deaths were discovered, raising mortality for this group by 2.5 per cent. In addition, 13 previously unmatched death records were linked to birth records, providing more accurate calculation of birthweight-specific mortality rates. Washington State infant death registration is more complete that that found in either Georgia or North Carolina.

Birth Certificates↗
PubMed1981

The mechanisms which affect the periodic cycle of Pacific Wuchereria bancrofti microfilariae.

1. Investigations were made of the effect of various procedures in raising or lowering the microfilaria count of Pacific type Wuchereria bancrofti in the peripheral blood. 2. Raising the body temperature in the early morning was followed by a moderate fall in the counts. Breathing increased oxygen, or reduced oxygen (hypoxia) or increased carbon dioxide, or the ingestion of sodium bicarbonate produced no consistent and significant change in the count. Ingestion of glucose (in one volunteer) was followed by a small rise in the count. Muscular exercise was followed by a fall in the count, which is interpreted as probably being a response to a lower concentration of oxygen in the venous blood returning to the lung. 3. It has not been possible to identify the physiological components on the circadian rhythm of the human body which entrain the cycle of these microfilariae. Attempts to obtain evidence incriminating the stimuli described above have been unsuccessful.

Adult↗
PubMed1979

A growth factor from spinal cord.

Mitogenic activity is present at a variety of sites in the central nervous system. A growth factor was purified from neonatal bovine spinal cord. It has a pI of 9.5-9.8 and a molecular weight of about 11,000 daltons. Spinal cord growth factor is a basic polypeptide that is inactivated by extremely acid or basic conditions. Its mobility on SDS polyacrylamide gels suggests that this factor is different from pituitary FGF and brain FGF-1.

Animals↗