PubMed Health⌕ Search

Biomedical subjects

T K Banerjee

Publications and source records attributed to T K Banerjee.

At least 55 records · Page 3Linked to original sources

Physiological adaptation in relation to hyperosmotic stress in the epidermis of a fresh-water teleost Barbus sophor (Cypriniformes, Cyprinidae): a histochemical study.

The changes in distribution of mucopolysaccharides, glycogen and protein bound sulphydryl groups of cysteine in the various cellular components of the epidermis of Barbus sophor along with its structural alterations as a result of hyperosmotic stress, have been described using histochemical techniques. The hyperosmotic saline induces a cyclic secretion of acid mucopolysaccharides by the mucous cells. Simultaneously the polygonal cells also show a marked disturbance in the processes of mucogenesis and keratinization, indicating an inverse relationship between the degree of keratinization and the amount of mucus secreted by epidermis. The role of glycogen in the polygonal cells has been discussed in relation to disturbed mucogenesis. The appearance of intercellular spaces in basal layer and middle layer has been correlated with the passage for movement of increased amounts of nutrients through the skin.

Adaptation, Physiological↗

Lipids in the skin of a cat-fish Heteropneustes fossilis (Bloch) (Heteropneustidae, Pisces). A histochemical investigation.

Localization and characterization of different lipids in the cellular constituents of the skin of Heteropneustes fossilis has been made using several histochemical techniques. High contents of cholesterol, its esters and phospholipids have been correlated with the metabolically active state of the basal cells undergoing cell proliferation and differentiation. The polygonal cells in the outermost layer of the epidermis, though rich in phospholipid contain small amounts of cholesterol and its esters. This has been correlated with the metabolically less active state of theses cells. Neutral lipids and phospholipids in the polygonal cells of the outermost layer may contribute to the contents of surface slime and act as an efficient barrier for the penetration of water through the skin. The deposits of neutral lipids in the subcutis may provide energy during the period of fasting, act as a barrier for water diffusion through the skin and serve as shock absorbing pads protecting the fish from mechanical injury.

Animals↗

A cytochemical study of the "chloride cells" in the skin of a fresh-water teleost (Channa striata (Bl.) Channidae, Pisces).

The chloride cells in the skin of Channa striata have been described. The cytoplasm of these cells is filled with acidophilic, osmiophilic and sudanophilic granules. The sudanophila is due to phospholipids. These cells give positive reaction for chloride ions and exhibit the presence of neutral mucopolysaccharides. The cytoplasm of these cells is packed with numerous mitochondria and exhibit high succinic dehydrogenase activity which may provide the energy needed for the active transportation of ions. Alkaline phosphatase activity could not be demonstrated in these cells. The presence of chloride cells in comparatively large numbers in the regions where the epidermis is thin is correlated as an adaptation for the increased efficiency of these cells for the transportation of ions so as to maintain the osmotic concentration of its body fluid which is higher than that of the surrounding medium.

Alkaline Phosphatase↗

High-dose diethylstilbestrol diphosphate therapy of prostatic cancer after failure of standard doses of estrogens.

Ten patients with metastatic prostatic cancer no longer responsive to conventional doses of estrogens (stilbestrol 15 mg. daily or equivalent) were treated with high doses of diethylstilbestrol diphosphate. Objective responses lasting from three to fifteen months were obtained in four patients; three of the patients had previously shown progressive disease following orchidectomy.Toxic manifestations consisted mainly of increased gynecomastia and water retention. No serious cardiovascular complications were encountered. This dose-response effect of estrogens indicates the persistence of hormone-dependent tumours in some patients with recurrent disease despite conventional estrogen therapy.

Body Fluids↗

Bone marrow transplantation in a patient with drug-induced aplastic anemia.

A 23-year-old woman gravely ill with Pseudomonas septicemia secondary to presumed drug-induced bone marrow aplasia received marrow transplantation from two male HL-A identical sibling donors. She had a successful engraftment with excellent but temporary clinical improvement. Subsequently she succumbed to graft-versus-host disease manifested by Pseudomonas and Candida albicans septicemia, cytomegalovirus pneumonitis, three phases of dermatitis, nausea, vomiting, dysphagia, diarrhea, fever, edema and bone pain, with gradual but complete graft suppression by the 74th day after the transplantation. A second marrow transplant on the 70th day was unsuccessful.

Anemia, Aplastic↗

Local versus regional procurement and distribution of granulocytes.

Granulocyte concentrates obtained by discontinuous flow centrifugation (DFC) and continuous flow centrifugation (CFC) were studied. The DFC granulocytes were obtained from a regional center and stored for 24 hours prior to transfusion. The CFC granulocytes were obtained locally and transfused within a few hours. Even at 24 hours, DFC granulocytes had significantly reduced bactericidal capacity, chemiluminescence, nitroblue tetrazolium reduction, chemotaxis and random mobility. Granulocyte kinetics utilizing DF32P and skin windows demonstrated the ability of DFC granulocytes to circulate and migrate into the tissues despite the in vitro abnormalities. Until effective storage techniques for granulocyte preservation became available, rapid transportation and processing from regional centers or local procurement of granulocytes is necessary to transfuse functional granulocytes.

Blood Bactericidal Activity↗