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Biomedical subjects

T Kitajima

Publications and source records attributed to T Kitajima.

At least 235 records · Page 13Linked to original sources
PubMed1977

Suppression of dibutylnitrosamine-induced bladder carcinomas in hamsters by dietary indole.

Effect of dietary indole on the urinary bladder tumorigenesis by chronic dibutylnitrosamine (DBN) treatment was evaluated in hamsters. In the first experiment, in which DBN-water and diet were given ad libitum, dietary indole significantly suppressed bladder tumor incidence. The inhibitory effect was more pronounced in males. In the second experiment, in which consumption of both diet and DBN-water was rigidly controlled by pair-feeding, dietary indole again significantly suppressed bladder tumor incidence; its effect was similar in both males and females. This suppressive effect of indole on bladder tumorigenesis contrasted markedly with its failure to suppress tumors at other sites such as nasal sinuses, trachea, esophagus, and fore-stomach.

Administration, Oral↗
PubMed1977

Continuous ECG monitoring on civil air crews during flight operations.

Cardiovascular disease is one of the disorders resulting in sudden incapacitation and is the most common malady leading to medical retirement. It is very important for us to control this disease among pilots. Generally, pilots undergo medical checkups at health control service on the ground, but they do not undergo these checkups during flight operations. We obtained a continuous ECG recording on four pilots to assess cardiac reserve capacity for mental load during flight operation. Results show that no significant ischemic changes of ST-segment and T-wave during flight were noticed except in one case of atrial fibrillation in which significant depression of ST-segment occurred while walking up a stairway after flight. An increased number of ectopic beats was found in another normal case. In general, it was suspected that mental load is greater at landing than takeoff.

Accidents, Aviation↗
PubMed1976

Effects of rapid round trips against time displacement on adrenal cortical-medullary circadian rhythms.

The effects of rapid round trips against time displacement on circadian rhythms was investigated. The study was carried out on three occasions using one volunteer healthy physician on east-west trips (Tokyo-San Francisco-Tokyo) of short and prolonged stays. The control study was performed on a north-south trip (Tokyo-Sydney-Tokyo) which had practically no time displacement. The circadian rhythms of urinary 17-OHCS, 17-KS, and noradrenaline excretions and plasma cortisol in short-stay trips were disrupted and not synchronized; however, the recovery was rapid with the circadian rhythms returning to normal within 1 to 2 d. On the other hand, the circadian rhythms of these variables in the control study were not disrupted. These results suggest that a short, overnight stay during the trip minimizes the ill effects due to time displacement.

17-Ketosteroids↗
PubMed1975

IgA glomerulonephritis in Japan.

A clinicopathological study was done on 85 Japanese patients with IgA glomerulonephritis. Of patients with glomerulonephritis whose clinical course is of slow progression, the presence of IgA glomerulonephritis was demonstrated immunohistologically. The majority of such patients presented with a mild degree of proteinuria and/or persistent microscopic hematuria. In 15% of the patients, recurrent gross hematuria was noted. These findings suggest that immunohistological study is important in dealing with adult patients with so-called idiopathic renal hematuria. Light-microscopic findings of IgA glomerulonephritis were divided into 4 groups. In 56% of the patients, diffuse stalk thickening of the mesangium was noted and in one third of them, small crescent formations were present. In 22% of the patients, focal segmental proliferation was noted. Diffuse mesangial deposition of IgA noted by immunofluorescence was considered to correspond to the characteristic nodular deposition detected by light microscopy and to the relatively large globular hemispheric deposits detected by electron microscopy.

Female↗