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T Kolawole

Publications and source records attributed to T Kolawole.

10 recordsLinked to original sources
PubMed1999

Sotos syndrome (cerebral gigantism): a clinical and radiological study of 14 cases from Saudi Arabia.

Fourteen children (of Arab ethnic origin) with Sotos syndrome are described. They were referred to King Khalid University Hospital, Riyadh between July 1992 and June 1997. Their phenotypic characteristics were compared with established diagnostic criteria. There was a male:female ratio of 1.3:1 and a high rate of consanguinity (36%) among parents. At birth, 54% were large and about one-third showed increased height and occipitofrontal head circumference (OFHC). The neonatal histories revealed respiratory and feeding problems in 21%, followed later by delayed motor milestones and speech development in 57%. During childhood, weight, height and OFHC increased further to > 97th centile in 71%, 71% and 93%, respectively. A seizure disorder affected 43%, and 75% had mental retardation (IQ < 70). A non-specific EEG abnormality was found in half of those with seizures. Cranial CT/MRI showed ventricular dilatation in 15% and one patient had corpus callosum dysgenesis. Abdominal ultrasound revealed hydronephrosis in two patients. Radiological cephalometric measurements showed relative prognathism in cases of Sotos syndrome compared with controls (p = 0.003). The study highlights the importance of considering Sotos syndrome in children who present with psychomotor delay.

Adolescent↗
PubMed1998

Moyamoya syndrome with unusual angiographic findings and protein C deficiency: review of the literature.

We describe the findings in a six-year-old female with typical clinical symptoms of Moyamoya phenomena, but with an unusual angiographic appearance. The vertebral artery showed segmented occlusion in the upper cervical region, with reconstitution via collateral circulation through muscular branches. The carotid circulation showed involvement of the external carotid artery (ECA) branches and marked narrowing of the internal carotid arteries (ICA) bilaterally, suggesting that this disease is systemic in nature.

Brain↗
PubMed1998

Ossification of the ligament flavum.

A total of 82 patients who underwent spinal computed tomographic scan, in an 8-month period at the King Khalid University Hospital, Riyadh, Saudi Arabia, were analyzed for age, sex, the presence/absence, site, and type of ossification of the ligamentum flavum (OLF) as well as associated diseases. The OLF was radiographically present (bilaterally or unilaterally) as linear (74.5%) or nodular types (25.5%). The linear type was especially seen at the inner aspects of the ligamentum flavum. OLF was present in 35.4% of patients, and was seen at single and multiple levels in 51% and 41% of them, respectively. OLF was identified in a total of 47 levels in the study group and was associated with other disease in the spine in 38 (81%) of these levels. In none of the patients was OLF the cause of myelopathy. The incidence of OLF and its pathogenesis and significance are discussed. This paper is the first report of OLF from the Middle East. OLF in this part of the world is usually asymptomatic.

Adolescent↗
PubMed1996

Cerebro-vasculopathy and malignancy: catastrophic complications of radiotherapy for optic nerve glioma in a von Recklinghausen neurofibromatosis patient.

The authors report a unique case of a patient with intraorbital optic nerve glioma and von Recklinghausen neurofibromatosis who developed cerebro-vasculopathy and malignant transformation in the orbit 18 months after radiotherapy treatment. The case is an important reminder of the possibly increased susceptibility of von Recklinghausen neurofibromatosis patients to the complications of radiotherapy.

Brain↗
PubMed1993

Dysgenesis of the corpus callosum: computed tomographic changes.

The CT findings in 32 cases of DCC are presented classifying them into three groups: Type I: Anatomical changes primarily due to callosal dysgenesis. Type II: Associated central nervous system anomalies. Type III: Incidental findings. The findings were compared with those of others. This study confirms that the CT findings which are of a high diagnostic index are those of Type I changes which include enlargement and elongation of the interventricular foramen, enlargement and continuity of the interhemispheric fissure with the third ventricle, which is invariably enlarged, elevation and anterior displacement of the third ventricle. Separation and parallelism of the lateral ventricle is also one of the most diagnostic features. Three rare syndromes (Soto's, Aicardi's and De Morsier's) and the rare occurrence of associated teratoma which were encountered as part of the associated congenital abnormalities are mentioned. The embryological basis of the CT findings is discussed.

Abnormalities, Multiple↗
PubMed1991

Brain atrophy in Werdnig-Hoffmann disease.

CT scan imaging of the brain was done in eight children with Werdnig-Hoffmann Disease. Seven of them showed generalized cerebral cortical atrophy and one had low attenuated, non-enhancing areas in the white matter involving both frontal lobes. These changes could be due to repeated episodes of hypoxic injury.

Atrophy↗
PubMed1988

Tumoral calcinosis: case reports from Saudi Arabia with a review of the literature.

Tumoral calcinosis is a rare disease mainly reported among blacks, especially from the tropical and sub-tropical regions of Africa. Hitherto, no reports of this disease entity have been reported from North Africa and the Arab Peninsula. This paper is therefore the first documentation of tumoral calcinosis in nine patients from the Arabian Peninsula; seven of whom are Saudis and two Yemenis. Peculiar osseous and joint changes co-existed in one of the cases. Moreover, there was a high incidence in the feet, in 75% of cases. One of the lesions was quite extensive. Reason for these changes are suggested.

Adult↗
PubMed1987

Adult geophagia--report of three cases with review of the literature.

This is the first report of three cases of adult geophagia in Saudi Arabia, two with a history of eating mud, and the third of eating pebbles. The presentation in these patients were of abdominal pains, with the radiographs showing very dense opacities within the intestine, especially the colon. These opacities were of varying sizes, and of varying densities, some of them polygonal in shape. These opacities changed in position with time differentiating them from other densities such as renal calculi with which they are may be confused. A review of the clinical and pathological changes of geophagia is given. The association of iron-deficiency anaemia, hepatomegaly, dwarfism and hypogonadism with a geophagia syndrome is noted and its pathogenesis explained. The role of socio-cultural and other predisposing factors in the aetiology of geophagia is discussed.

Abdomen↗