Brain atrophy in Werdnig-Hoffmann disease.

M Yohannan; P Patel; T Kolawole; T Malabarey; A Mahdi

doi:10.1111/j.1600-0404.1991.tb04982.x

Home/Archive/PubMed

PubMed · 1776391

Brain atrophy in Werdnig-Hoffmann disease.

M Yohannan·P Patel·T Kolawole·T Malabarey·A Mahdi

View original source ↗Export metadata ↓

Abstract

CT scan imaging of the brain was done in eight children with Werdnig-Hoffmann Disease. Seven of them showed generalized cerebral cortical atrophy and one had low attenuated, non-enhancing areas in the white matter involving both frontal lobes. These changes could be due to repeated episodes of hypoxic injury.

Explore related subjects

Atrophy Brain Cephalometry Diagnosis, Differential Female Follow-Up Studies Humans Infant Infant, Newborn Male Neurologic Examination Spinal Muscular Atrophies of Childhood Tomography, X-Ray Computed Journal Article

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

M Yohannan, P Patel, T Kolawole, T Malabarey, A Mahdi. 1991. Brain atrophy in Werdnig-Hoffmann disease.. https://doi.org/10.1111/j.1600-0404.1991.tb04982.x

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Cavum septum pellucidum in patients with first episode psychosis and individuals at high risk of psychosis.

Explore the source record for details and available documents.

Atrophy↗

PubMed2007

Multiple sclerosis.

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that commonly leads to inflammatory and atrophic brain pathology, often causing cognitive impairment. MS-associated cognitive impairment was first described over a century ago. However, with the advent of standardized neuropsychological testing and quantitative brain imaging, the frequency, quality, and correlates of cognitive impairment are better understood. Dementia is rare in MS, although it is known to occur in 10 to 25% of patients. Our data suggest a frequency of 22% among clinic attendees. In addition to the cognitive impairments evident in MS dementia, changes in personality and social behavior also occur. For example, some patients develop euphoria sclerotica and marked deficiency in social empathy, conditions that in combination with executive dysfunction cause considerable hardship for patients and caregivers. These neuropsychiatric manifestations of MS dementia are correlated with magnetic resonance imaging indicators of brain atrophy, including ventricle enlargement, neocortical volume, and normalized whole brain volume. Recent developments in pharmacological treatment for disease progression and management of cognitive symptoms hold promise for patients suffering from the degenerative aspects of MS.

Atrophy↗

PubMed2007

Inflammation, atrophy, and gastric cancer.

The association between chronic inflammation and cancer is now well established. This association has recently received renewed interest with the recognition that microbial pathogens can be responsible for the chronic inflammation observed in many cancers, particularly those originating in the gastrointestinal system. A prime example is Helicobacter pylori, which infects 50% of the world's population and is now known to be responsible for inducing chronic gastric inflammation that progresses to atrophy, metaplasia, dysplasia, and gastric cancer. This Review provides an overview of recent progress in elucidating the bacterial properties responsible for colonization of the stomach, persistence in the stomach, and triggering of inflammation, as well as the host factors that have a role in determining whether gastritis progresses to gastric cancer. We also discuss how the increased understanding of the relationship between inflammation and gastric cancer still leaves many questions unanswered regarding recommendations for prevention and treatment.

Atrophy↗