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Biomedical subjects

T Kumoi

Publications and source records attributed to T Kumoi.

At least 19 recordsLinked to original sources
PubMed1995

Evaluation of mastoid obliteration surgery.

The anatomic results of mastoid obliteration surgery on 54 ears during the past 10 years were analyzed, and the comparative utility of several materials for obliteration was evaluated. Thirty-three ears had primary chronic otitis media with or without cholesteatoma (group 1), and 21 ears had old open mastoid with intractable chronic discharge due to incomplete epithelialization (group 2). The materials used for obliteration were biologic (pedicled muscle flap, autogenous bone chips, tragal cartilage with perichondrium, allograft dura), nonbiologic (hydroxyapatite), or a combination of two of these materials. Evaluation at 2 months postoperatively showed that 42 ears were anatomically complete, whereas the other 12 ears were incomplete: three cases in group 1 and nine cases in group 2. The main causes of these unsatisfactory results were exposure of transplanted artificial material or partial loss of the pedicled muscle flap. In the long-term follow-up results, four ears were evaluated as unsatisfactory in group 1, and six ears in group 2, owing to shrinkage of obliterated tissue. The major causes of failure were anatomic incompleteness following surgery for old open mastoid cavity, in which the use of biologic materials for obliteration was much safer than nonbiologic material, and from the protrusion of artificial materials used.

Biocompatible Materials↗
PubMed1994

Developmental anomaly of the process of Folius.

We present four cases of an ossicular anomaly considered to consist of an abnormality of the anterior process and manubrium mallei (malleus handle). In one case, a thick bony bar was found extending from the neck of the malleus which fused with the posterior bony wall or the tympanic bone. No trace of the short process and umbo of the malleus was recognized. In two other cases, a similar bony bar was seen as well as a cartilaginous malleus handle that apparently was attached to the anterior part of the bony bar. On the basis of these findings, the bony bar was assumed to represent abnormally developed mesenchyme bone (os goniale), which later develops into the anterior process of the malleus. In the last case, no bony bar was seen, but a V-shaped ossicle was recognized, one end of which was connected to the malleus head by fibrous tissue. Since this abnormally shaped ossicle was bony and hard and no trace of the short process and umbo characteristic of the handle of the malleus was found, it was though to be an abnormally developed os goniale.

Adult↗
PubMed1993

Dermoid cyst in the middle ear.

A case of a moderate essentially low tone unilateral conductive hearing loss without a previous history of secretory otitis media in a six-year-old female patient is described. The condition was found to be due to a dermoid cyst in the tympanic cavity, which was confirmed by pathological examination of the surgically removed specimen. This is the sixth documented case of dermoid cyst in the tympanic cavity.

Child↗
PubMed1993

The embryologic development of the human anterior nasal aperture.

During the final period of embryogenesis, the nasal pit is clearly apparent in the Carnegie stage 15 embryo, and extends backwards into the oral cavity forming the nasal sac. In the stage 19 embryo of about 7 weeks, abundant epithelial proliferation into the lumen forms the nasal meatal plug. The complete recanalization of this meatal plug occurs in the 16-17 week fetus, and not in the 24th week of fetal life as is generally accepted in textbooks on human embryology. The findings of the present study of the embryology of the anterior nares can well explain the anomalies of the human anterior nares aperture.

Embryonic and Fetal Development↗
PubMed1993

Ultracytochemical study of ouabain-sensitive K(+)-dependent p-nitro-phenylphosphatase activity in stria vascularis of reserpinized guinea pigs.

In order to clarify the effect of reserpine on the Na(+)-K+ active transport in the stria vascularis we investigated the localization of ouabain-sensitive K(+)-dependent p-nitro-phenylphosphatase (K-NPPase) activity in the stria vascularis of reserpinized guinea pigs using the cerium-based method. The K-NPPase activity in marginal cells differed from cell to cell, and was almost completely absent in some cells. These results are consistent with the previous results and suggest that Na(+)-K+ active transport in the stria vascularis may be inhibited by reserpine administration.

4-Nitrophenylphosphatase↗
PubMed1993

Hemorrhage from spontaneous rupture of a parathyroid adenoma (a case report).

A case of extracapsular hemorrhage from spontaneous rupture of a parathyroid adenoma is reported. In the case presented here, adenoma was revealed by a sudden onset of a huge ecchymosis and hematoma of the entire anterior neck and right chest, causing recurrent nerve paresis. These cases of hemorrhage from rupture of silent parathyroid adenoma mimicking a dissecting thoracic aortic aneurysm are discussed.

Adenoma↗
PubMed1992

A case of congenital ossicular malformation with mild auricular deformity: embryological and surgical considerations.

A case of bilateral congenital conductive deafness with mild auricular deformity is presented, and the anomalous structure deformity of the ossicles was multi-focal in this case, and a previous report indicates that ossicular malformation in the ear with congenital conductive deafness is multi-focal when the external ear is only slightly deformed. Bilateral ossicular reconstruction with replacement of the stapes yielded satisfactory results.

Acoustic Impedance Tests↗
PubMed1992

Animal model for ischemic facial nerve paralysis with selective vascular embolization.

An experimental model that reliably and easily produces acute ischemic facial nerve paralysis would be useful for the controlled study of treatment and to improve our understanding of the pathophysiology and treatment of facial nerve palsy. Most documented models that simulate clinical facial nerve palsy cause direct damage to the nerve. We describe an experimental model for ischemic facial nerve paralysis in the cat that employs arterial block of the internal and external maxillary and posterior auricular arteries using embolizing material (Avitene). All animals develop stable acute ischemic facial nerve palsy lasting for approximately 2 months. Electromyographic study of this model revealed that the site of the lesion resulting from selective embolization may be within the temporal bone. This model has the advantages of simplicity of technique, cost-effective use of cats, and reproducibility of facial nerve palsy.

Animals↗
PubMed1992

The embryologic development of the human external auditory meatus. Preliminary report.

During the final period of embryogenesis, a funnel-shaped tube continues medially into the mesenchymal tissue forming a curved path. Although this may sound simple, the development occurring during early fetal life is in fact very complex. At first, ectodermal cells proliferate to fill the lumen of the meatus, forming the meatal plug, and then at 10 weeks the bottom of the plug extends in a disc-like fashion, so that in the horizontal plane the meatus is boot-shaped with a narrow neck and the sole of the meatal plug spreading widely to form the future tympanic membrane medially. At the same time, the plug in the proximal portion of the neck starts to be resorbed. In the 13-week fetus, the disc-like plug begins to show signs of its final destiny; the innermost surface of the plug in contact with the anlage of the malleus is ready to contribute to the formation of the tympanic membrane. In the 15-week fetus, the innermost portion of the disc-like plug splits, leaving a thin ectodermal cell layer of immature tympanic membrane. The neck of the boot forms the border between the primary and secondary meatus, and is the last part to split. In the 16.5-week fetus, the meatus is fully patent throughout its entire length, although the lumen is still narrow and curved. In the 18-week fetus, the meatus is already fully expanded to its complete form.

Cartilage↗
PubMed1992

[A phase I study on a weekly schedule of DWA2114R].

A phase I study on a weekly schedule of DWA 2114R, a new platinum analogue, was conducted in 21 patients with various tumor types by clinical groups at 10 institutions. Nineteen of the 21 patients entered in this study were evaluable. The starting dose was 200 mg/m2 (1 n) administered intravenously for 1 hr and gradually escalated stepwise to 700 mg/m2 (3.5 n). The dose limiting factor (DLF) was leukocytopenia, especially neutropenia and maximum tolerated dose (MTD) was 700 mg/m2. The major clinical toxicity was gastrointestinal. Nephrotoxicity and hepatotoxicity were mild. Ototoxicity and cardiac failure did not emerge. Following administration of the drug, total platinum (Pt) showed a biphasic decay and AUC of total Pt was dependent on the dose. Excretion into urine 24 hr was between 42.6 and 100% of the administered platinum. The recommended dose of phase II study on a weekly schedule was 600 mg/m2, repeated every 2 or 3 weeks and administered via intravenous within drip infusion.

Adult↗
PubMed1991

Hydrogen peroxide generation by eosinophils in allergic rhinitis.

It was the aim to study the hydrogen peroxide (H2O2) generation by eosinophils in allergic rhinitis caused by house dust which was examined in nasal secretion and peripheral blood. The concentration of H2O2 in nasal secretions was increased after nasal challenge with house dust, and subsided gradually by the increase of peroxidase activity. The population of eosinophils and H2O2 generation which was morphologically detected on the plasma membrane of eosinophils in nasal secretion, were increased with the release of eosinophil chemotactic activity after nasal challenge. Also, in peripheral blood, the number and phagocytic activity of eosinophils in extremely high density 1.102 g/ml were increased after nasal challenge. A high number of eosinophils was found in a density of 1.097 g/ml in the high IgE group, but showed less phagocytic activity than in the lower IgE group. Considering from these findings, H2O2 generation by eosinophils appeared to be an important event in tissue injury and augmentation of allergic reaction.

Adolescent↗