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T L Sherman

Publications and source records attributed to T L Sherman.

4 recordsLinked to original sources
PubMed1993

Paroxetine: a new serotonin reuptake inhibitor for the treatment of depression.

The introduction of the selective serotonin reuptake inhibitors (SSRIs) over the past several years has made a major impact on the treatment of depression and other neuropsychiatric disorders. Agents in this heterogeneous group of compounds are generally better tolerated and less toxic than the tricyclic antidepressants (TCAs), which they have in many respects superseded. This review summarizes available data on paroxetine, the newest SSRI to receive approval for the treatment of depression.

Depressive Disorder↗
PubMed1984

Patterns of electrochemical proton gradient formation by membrane vesicles from an obligately acidophilic bacterium.

Isolated membrane vesicles from the obligately acidophilic bacterium Bacillus acidocaldarius generated an electrochemical gradient of protons (delta mu- H+) upon energization with ascorbate-phenazine methosulfate at pH 6.0 or 3.0. At pH 6.0, there was little or no transmembrane pH gradient (delta pH), but a transmembrane electrical potential (delta psi) of ca. -77 mV, positive out, was observed. At pH 3.0, a delta pH equivalent to - 100 mV, acid out, and a delta psi of -73 mV, positive out, were observed upon energization. The total magnitude of the delta mu- H+ was higher than that of whole cells at acid pH, but the very large delta pHs and the reversed delta psi s, i.e., inside positive, that are typical of acidophile cells were not observed in the vesicles. The vesicles exhibited energy-dependent accumulation of alpha-aminoisobutyric acid that was inhibited by both nigericin and valinomycin (plus K+) at pH 3.0 but was inhibited little by nigericin at pH 6.0.

Aminoisobutyric Acids↗
PubMed1983

Allocating your merit increases the SMART way.

Although other formulas for determining merit increases can be developed and implemented successfully, the formula described in this article has been used successfully on a relatively large group of employees. Proper utilization of this method requires effective job evaluation and performance appraisal programs, both of which must have the capability of being summarized quantitatively. Human resource managers generally believe that employee performance is a function of an employee's ability and motivation and that money acts as a motivator. If you share this belief, then you must assure the employees you serve that they will be rewarded impartially and without predilection. The Systematic Merit Allocation Reward Technique is one method through which you can provide this needed assurance.

Employee Performance Appraisal↗