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Biomedical subjects

T L Zaets

Publications and source records attributed to T L Zaets.

At least 19 recordsLinked to original sources
PubMed1992

Enteral hyperalimentation of burned patients: the possibility of correcting metabolic disorders by the early administration of prolonged high calorie evenly distributed tube feeds.

Metabolic processes and the ways they may be treated were investigated in severely burned patients receiving prolonged high calorie evenly distributed tube feedings. It was shown that in critically ill patients the absorption of nutrients in the upper regions of the intestine was slightly impaired but the ability to absorb was preserved, which made it possible to provide prolonged evenly distributed tube feeding. For these purposes we used the nutrient mixture 'Combustal'. Restoration of nitrogen balance could be reached within about 10 days after starting tube feeding. However, the creatine excretion remained high, a manifestation of increased dystrophy of muscle tissue. Pseudocholinesterase activity in serum was also decreased, suggesting subnormal biosynthetic processes. To provide the full correction to normal of the metabolic processes the tube feeding with 'Combustal' should be given for at least a month.

Adolescent↗
PubMed1990

[Changes in several characteristics of the erythrocyte membrane and erythrocyte structure in severe burns in animal experiments].

It is determined in experiments on rats that the IIIB degree thermal injuries of 20% of the total body surface significantly reduce the erythrocytic membrane's resistance and cause the production of peroxides in 15 minutes after trauma. Simultaneously the electrical properties begin to change. The structure of erythrocytes is also altered. In 30 minutes post injury these alterations are in progress, but in 60 minutes they are less expressed. The structure of the erythrocytes is significantly altered. The authors consider that the influence of membranotoxic factors--the products of free radicals' reactions and phospholipases--is accounted for all noticed alterations.

Animals↗
PubMed1987

[Blood phospholipases in burn shock].

The activity of blood plasma phospholipases A and C has been observed during burn shock periods in patients with severe burns affecting more than 20% of the body surface. It was experimentally demonstrated that the enzyme plasma activity increased 30 minutes after burning. Simultaneously, intensification of lipid peroxidation took place. Phospholipases are suggested to liberate from the damaged tissues with their following activation by free-radical products.

Animals↗
PubMed1986

[Therapeutic plasmapheresis in acute burn toxemia].

Curative plasmapheresis was used in 10 critically burned patients at the stage of acute burn toxemia with the delirious syndrome with the unfavourable prognosis. Good immediate results were obtained in all the patients: psychic disorders were arrested by the end of the procedure. Clinico-laboratory data have shown the curative plasmapheresis to be an effective detoxicating method resulting in the elimination of various toxic substances from the organism.

Adult↗
PubMed1986

[Changes in the met- and leu-enkephalin levels in the rat brain during burn shock].

The dynamics of met-and leu-enkephalin content in the brain cortex and hypothalamus of rats with severe burn shock caused by 50% burns by boiling water were studied. A tendency towards burn-induced growth in leu-enkephalin hypothalamus level was observed, with the content of met-and leu-enkephalins in the hypothalamus significantly increasing 30 min later. Met-enkephalin content in the brain cortex also rises. 2 hours later the changes are less pronounced, with met-enkephalin hypothalamus level remaining elevated. The adaptive nature of changes, mobilization of endogenous anti-pain defensive mechanisms in severe burn shock and the role of hypothalamus structures in this process are suggested.

Animals↗
PubMed1983

[Structural and enzymatic disorganization of biological membranes in rat liver cells in thermal burns].

Permeability of hepatocyte cell membrane was studied from the release into blood of hepatospecific enzymes and from 5'-nucleotidase activity in plasma membranes. A study was also made of membrane permeability of mitochondria, lysosomes and microsomes in liver cells of burnt rats from the level of non-sedimented activity and activity of malate dehydrogenase, succinate dehydrogenase, cathepsin D and glucose-6-phosphatase in appropriate organelles. Permeability of cell and lysosomal membranes was demonstrated to be disordered within the first hours after burn. One day after burn generalized disturbance of membrane permeability in the cell was observed, followed by the release into cytosol of organelles template enzymes and a decrease in the activity of membrane-bound enzymes in these organelles. The alterations persisted during 7 days of observation.

5'-Nucleotidase↗