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Biomedical subjects

T Laudański

Publications and source records attributed to T Laudański.

At least 19 recordsLinked to original sources
PubMed1995

[Acid-base balance in capillary blood of newborns with perinatal hypoxemia symptoms].

The purpose of the study was to compare acid-base parameters in capillary blood of newborns from groups with hypoxaemia symptoms and from the control group (physiological deliveries). 111 newborns were divided into 8 groups. Group I consisted of 33 newborns from uncomplicated labour while groups II-VIII involved newborns from complicated labor with symptoms of hypoxaemia. Capillary blood was taken in the 10th and 60th minute and after 24 hours of newborn's life. In newborns with pathological CTG, green amniotic fluid and prolonged first stage of labour--higher duration of acidosis was observed.

Acid-Base Equilibrium↗
PubMed1994

[Trial for assessment of values: normal, threatening, and pathologic parameters of acid-base equilibrium in umbilical vessel blood and capillary blood in newborns].

A prospective study in 33 newborns infants born spontaneously at term was carried out. First stage labour duration was up to 10 hours while the second one was no longer than 60 minutes. The key criterion for newborns selection from physiological deliveries was a normal heart rate baseline throughout the whole period of labour. Acid-base parameters in umbilical blood vessels and capillary blood were performed on an Blood Analyzer Corning 168. The results allowed to define normal and pathological ranges of the analysed indicators. They may be used for evaluation of newborn's postnatal conditions.

Acid-Base Equilibrium↗
PubMed1994

[Acid-base equilibrium in umbilical blood vessels of fetuses with perinatal hypoxemia symptoms].

The aim of the study was to compare acid-base parameters in umbilical cord blood of fetus from groups with hypoxaemia symptoms and from the control group (physiological deliveries). 111 fetuses were divided into 8 groups. Group I consisted of 33 fetuses with normal heart rate baseline while groups II-VIII involved fetuses from complicated labours with hypoxaemia symptoms. The following characteristics of umbilical vessels blood: low pH, normal or increased PCO2, increased base deficit, low PO2 and PO2 in chronic hypoxaemia were found out. Acute hypoxaemia was characterised by lower pH, high PCO2, normal BE and lower PO2 and SO2.

Acid-Base Equilibrium↗
PubMed1991

Influence of cadmium ions on the reactivity of isolated human uterine arteries.

The isometric contractions were recorded for pieces of uterine arteries as well as ascending branches of uterine artery (1-2 mm diameter) obtained from 36 nonpregnant, premenopausal women undergoing hysterectomy. Contractile responses to K(+)-depolarization, noradrenaline, and Ca+2 ions were studied. Cadmium at concentrations 10(-9)-10(-3) M produced no changes of tension in the investigated arteries. Incubation (15 min) with low concentration of cadmium (10(-9)-10(-7) M) evoked an increase of amplitude of K(+)-induced contractions in 50% of investigated vessels. Cadmium at concentrations of 10(-6)-10(-3) M gradually inhibited contractions. The influence of cadmium on contractions evoked by noradrenaline was similar to those on K(+)-induced contractions. In a Ca(2+)-free medium, 10(-5) M cadmium induced tonic contractions and pretreatment with 10(-7) and 10(-5) M cadmium slightly enhanced Ca(2+)-induced contractions. Cadmium concentration of 10(-4) M caused substantial inhibition of Ca(2+)-induced contractions. The results suggest that in the human uterine vessels cadmium is not only a Ca(2+)-channels blocker but also interferes with intracellular mechanisms involved in excitation-contraction coupling.

Adult↗
PubMed1990

Induction of labor in intrauterine fetal death with 16-phenoxy-prostaglandin-E2-methylsulfonylamide (sulprostone)--effects on uterine contractility, coagulation and kallikrein-kinin systems.

Thirty-two patients with intrauterine fetal death after the 20th week of pregnancy were treated with 1-3 intramuscular injections of 500 mg of 16-phenoxy-PGE2-methylsulfonylamide (sulprostone). Intrauterine pressure records demonstrated onset of contractions within 20 min of injection and all women aborted-delivered after in mean 11 h (4-31 h). No effect on routine hematologic and plasma parameters, kallikrein-kinin and factor XII systems was observed. It is concluded that 16-phenoxy-PGE2-methylsulfonylamide is an effective and safe oxytocic agent for the induction of labor in case of intrauterine fetal death with minimal effects on the coagulation system.

Adult↗
PubMed1989

The influence of a combined oral contraceptive on uterine activity and reactivity to agonists in primary dysmenorrhea.

The mechanisms underlying the therapeutic effect of an oral contraceptive (150 micrograms levonorgestrel and 30 micrograms ethinyl estradiol daily for 21 days) in primary dysmenorrhea were studied by recordings of uterine activity and reactivity to lysine (L) vasopressin (VP) and prostaglandin (PG) F2 alpha on the first day of menstruation in 14 women before and after one period of oral contraceptive treatment. During the first session, when all women had moderate to severe dysmenorrhea, intra-uterine pressure recording showed an intensive uterine activity, and bolus injections of LVP (6 pmol/kg body weight; 6 subjects) or PGF2 alpha (6 or 12 nmol/kg body weight; 4 subjects in each group) increased contractile activity and discomfort. After oral contraceptive treatment, spontaneous uterine activity, measured as total pressure area, decreased significantly (p = 0.02 and p = 0.03 in the VP and PG groups, respectively). The mean uterine responses to LVP and PGF2 alpha were on average smaller after oral contraceptive treatment and the women experienced minimal discomfort after this injection. It is suggested that inhibition of uterine activity could be an important mechanism for the therapeutic effect of gestagen-dominated oral contraceptives in primary dysmenorrhea and that reduced uterine reactivity to agonists might contribute to this effect.

Adolescent↗
PubMed1985

[Energy metabolism of the myometrium in pregnancy and labor].

The strips of uterine muscle were taken during the caesarean section and the levels of energetic substrates (glycogen and FFA), glycolysis products (pyruvate and lactate), highenergetic phosphates were estimated and the activity of selected carbohydrate metabolism enzymes was tested--in the homogenates in relation to the type of uterine contractility. Further the protein metabolism enzymes were estimated also (AspAT, ALAT, GlDH); including CPK. It was demonstrated that the energetic metabolism of the uterine muscle is different in pregnancy and in labour and depends on the type of uterine contractility.

Adenosine Diphosphate↗
PubMed1984

Interaction of vasopressin and prostaglandins in the nonpregnant human uterus.

The interaction of vasopressin (VP) and prostaglandins (PG) on the nonpregnant human uterus was studied in vitro and in vivo. In organ baths arginine (A)- and lysine (L)-VP in concentrations of 0.6 to 100 ng/ml stimulated small human myometrial strips and uterine artery preparations to a similar degree. When these VPs were given in the presence of indomethacin or naproxen in concentrations of 1 microgram/ml and 5 micrograms/ml, respectively, the myometrial and arterial responses were not significantly influenced. PGF2 alpha in concentrations of 0.01-100 ng/ml stimulated the myometrial preparations but caused a slight relaxation of the arteries, with PGE2 the myometrial effects were insignificant and the relaxation of the arteries greater. When AVP was given together with either of the PGs to the bath the result was generally a summation of the individual effects of both types of substances.--In vivo during intrauterine pressure recordings in nonpregnant women 1-2 days before onset of menstruation LVP in single intravenous injection of 1.2 micrograms markedly stimulated uterine contractions. The response remained practically unaltered after pretreatment with 500 micrograms of naproxen given orally. The responses to LVP were also closely similar before, during and after intravenous infusion of PGF2 alpha at a rate of 5 micrograms/min.--It is concluded that the effect of VP on myometrium and uterine arteries is not to any great extent mediated by local synthesis of PG and that PGs do not cause potentiation or inhibition of the VP effects on the nonpregnant uterus.

Arginine Vasopressin↗
PubMed1982

Dopamine influence on human uterine activity at term pregnancy.

The influence of dopamine on uterine activity was studied by external tocography in women at the end of a normal pregnancy. In those who were not in labour dopamine infusion (2 micrograms min-1 kg-1 body weight) induced regular uterine contractions and with higher doses the response increased. For women in spontaneous labour, dopamine at a dose of 4 micrograms min-1 kg-1 caused a significant increase in the frequency of contraction, but in women receiving an oxytocin infusion, no further stimulation was seen. Dopamine did not have any noticeable effect on fetal heart rate, maternal pulse rate or blood pressure and no other general effects were observed.

Dopamine↗
PubMed1980

Uterine effects of N-alpha-triglycyl-(8-lysine)-vasopressin and 8-lysine-vasopressin in the first trimester of pregnancy.

Myometrial effects of a vasopressin hormonogen (N-alpha-triglycyl-(8-lysine)-vasopressin, TGLVP) and of 8-lysine-vasopressin (LVP) were studied in early pregnancy. Intrauterine pressure was recorded in 28 women, who were to have a therapeutic abortion at 8-12 weeks of gestation, and intravenous injection of TGLVP (0.5 and 1 mg) or LVP (0.1, 0.2 and 0.4 IU) were given, or control recordings without drug injection were obtained. TGLVP generally caused a biphasic increase in uterine activity with a rise in uterine tone as the most conspicuous initial effect followed by an increase in amplitude and duration of contractions. In the higher dose group the uterine activity remained significantly higher than in the controls during the rest of the recording period of 4-7 h. The magnitude of effect with the two doses of TGLVP did not differ significantly. The initial myometrial response to LVP resembled that to TGLVP but the effects disappeared within 10-45 min. In the controls the uterine activity did not change. It is suggested that vasopressin analogues could have a therapeutic value in the induction of abortion, but further basic studies are required to define this.

Adult↗
PubMed1980

Interaction of vasopressin and prostaglandin on myometrial activity in vivo in the first trimester of human pregnancy.

The interaction of vasopressin (VP) and prostaglandin (PG) F2 alpha on myometrial activity was studied by intrauterine pressure recording in 40 women due to undergo therapeutic abortion in the first trimester. In a control group the uterine activity did not change during eight hours of recording without drug administration. In a second group, who had intravenous injections of 8-lysine vasopressin (LVP, 0.1-0.5 IU), it was found that 0.3 IU was the smallest dose that consistently gave an effect on myometrial activity, and that repeated injections gave responses of practically the same magnitude. In the remaining women in the study, LVP injections, 0.3 IU, were given before, during and two hours after an intravenous infusion of PGF2 alpha at 4 or 20 micrograms/minute. Although there were great individual variations, potentiation and enhancement of the LVP effect were the most common reactions, especially with the lower dose of PG. An interaction of PG and other endogenous myometrial stimulants such as VP might be important in the aetiology of spontaneous abortion and the combination of PG with VP-like substances might be of value in therapeutic abortion during the first trimester.

Adult↗
PubMed1979

Progesterone effects on the evolution of myometrial activity in vivo in the non-pregnant rabbit.

In order to study the influence of progesterone on the myometrial activity ovarian secretion of progesterone was stimulated by intravenous injection of human chorion gonadotrophin (HCG, 75 IU) in 9 nonpregnant rabbits. 4 rabbits, used as controls, were given only saline. Plasma progesterone concentration in blood samples taken at frequent intervals (2-4 h) during the recording was measured by radioimmunoassay. In the controls, the myometrial activity and the plasma levels of progesterone did not change. After 1 h of HCG administration the amplitude of contraction began to decrease and the frequency began to increase after 3 h. After about 5 h the changes in amplitude and frequency were generally fully developed. This pattern of myometrial activity persisted throughout the recording period (12 h) and was also present in recordings made after 24 and 48 h of HCG injection. A maximal increase in plasma progesterone concentration (5.0 ng/ml) had already occurred by 2 h after the HCG injection and gradually decreased thereafter. It is concluded that an elevation in the level of progesterone in non-pregnant rabbits resulting from increased ovarian output (through HCG) has a pronounced and immediate depressing effect on the character of myometrial activity which is indicative of a shift from nonpregnant to pregnant type.

Animals↗