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Biomedical subjects

T Laudański

Publications and source records attributed to T Laudański.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Energy metabolism of the myometrium in pregnancy and labor].

The strips of uterine muscle were taken during the caesarean section and the levels of energetic substrates (glycogen and FFA), glycolysis products (pyruvate and lactate), highenergetic phosphates were estimated and the activity of selected carbohydrate metabolism enzymes was tested--in the homogenates in relation to the type of uterine contractility. Further the protein metabolism enzymes were estimated also (AspAT, ALAT, GlDH); including CPK. It was demonstrated that the energetic metabolism of the uterine muscle is different in pregnancy and in labour and depends on the type of uterine contractility.

Adenosine Diphosphate↗
PubMed1984

Interaction of vasopressin and prostaglandins in the nonpregnant human uterus.

The interaction of vasopressin (VP) and prostaglandins (PG) on the nonpregnant human uterus was studied in vitro and in vivo. In organ baths arginine (A)- and lysine (L)-VP in concentrations of 0.6 to 100 ng/ml stimulated small human myometrial strips and uterine artery preparations to a similar degree. When these VPs were given in the presence of indomethacin or naproxen in concentrations of 1 microgram/ml and 5 micrograms/ml, respectively, the myometrial and arterial responses were not significantly influenced. PGF2 alpha in concentrations of 0.01-100 ng/ml stimulated the myometrial preparations but caused a slight relaxation of the arteries, with PGE2 the myometrial effects were insignificant and the relaxation of the arteries greater. When AVP was given together with either of the PGs to the bath the result was generally a summation of the individual effects of both types of substances.--In vivo during intrauterine pressure recordings in nonpregnant women 1-2 days before onset of menstruation LVP in single intravenous injection of 1.2 micrograms markedly stimulated uterine contractions. The response remained practically unaltered after pretreatment with 500 micrograms of naproxen given orally. The responses to LVP were also closely similar before, during and after intravenous infusion of PGF2 alpha at a rate of 5 micrograms/min.--It is concluded that the effect of VP on myometrium and uterine arteries is not to any great extent mediated by local synthesis of PG and that PGs do not cause potentiation or inhibition of the VP effects on the nonpregnant uterus.

Arginine Vasopressin↗
PubMed1982

Dopamine influence on human uterine activity at term pregnancy.

The influence of dopamine on uterine activity was studied by external tocography in women at the end of a normal pregnancy. In those who were not in labour dopamine infusion (2 micrograms min-1 kg-1 body weight) induced regular uterine contractions and with higher doses the response increased. For women in spontaneous labour, dopamine at a dose of 4 micrograms min-1 kg-1 caused a significant increase in the frequency of contraction, but in women receiving an oxytocin infusion, no further stimulation was seen. Dopamine did not have any noticeable effect on fetal heart rate, maternal pulse rate or blood pressure and no other general effects were observed.

Dopamine↗
PubMed1980

Uterine effects of N-alpha-triglycyl-(8-lysine)-vasopressin and 8-lysine-vasopressin in the first trimester of pregnancy.

Myometrial effects of a vasopressin hormonogen (N-alpha-triglycyl-(8-lysine)-vasopressin, TGLVP) and of 8-lysine-vasopressin (LVP) were studied in early pregnancy. Intrauterine pressure was recorded in 28 women, who were to have a therapeutic abortion at 8-12 weeks of gestation, and intravenous injection of TGLVP (0.5 and 1 mg) or LVP (0.1, 0.2 and 0.4 IU) were given, or control recordings without drug injection were obtained. TGLVP generally caused a biphasic increase in uterine activity with a rise in uterine tone as the most conspicuous initial effect followed by an increase in amplitude and duration of contractions. In the higher dose group the uterine activity remained significantly higher than in the controls during the rest of the recording period of 4-7 h. The magnitude of effect with the two doses of TGLVP did not differ significantly. The initial myometrial response to LVP resembled that to TGLVP but the effects disappeared within 10-45 min. In the controls the uterine activity did not change. It is suggested that vasopressin analogues could have a therapeutic value in the induction of abortion, but further basic studies are required to define this.

Adult↗
PubMed1980

Interaction of vasopressin and prostaglandin on myometrial activity in vivo in the first trimester of human pregnancy.

The interaction of vasopressin (VP) and prostaglandin (PG) F2 alpha on myometrial activity was studied by intrauterine pressure recording in 40 women due to undergo therapeutic abortion in the first trimester. In a control group the uterine activity did not change during eight hours of recording without drug administration. In a second group, who had intravenous injections of 8-lysine vasopressin (LVP, 0.1-0.5 IU), it was found that 0.3 IU was the smallest dose that consistently gave an effect on myometrial activity, and that repeated injections gave responses of practically the same magnitude. In the remaining women in the study, LVP injections, 0.3 IU, were given before, during and two hours after an intravenous infusion of PGF2 alpha at 4 or 20 micrograms/minute. Although there were great individual variations, potentiation and enhancement of the LVP effect were the most common reactions, especially with the lower dose of PG. An interaction of PG and other endogenous myometrial stimulants such as VP might be important in the aetiology of spontaneous abortion and the combination of PG with VP-like substances might be of value in therapeutic abortion during the first trimester.

Adult↗
PubMed1979

Progesterone effects on the evolution of myometrial activity in vivo in the non-pregnant rabbit.

In order to study the influence of progesterone on the myometrial activity ovarian secretion of progesterone was stimulated by intravenous injection of human chorion gonadotrophin (HCG, 75 IU) in 9 nonpregnant rabbits. 4 rabbits, used as controls, were given only saline. Plasma progesterone concentration in blood samples taken at frequent intervals (2-4 h) during the recording was measured by radioimmunoassay. In the controls, the myometrial activity and the plasma levels of progesterone did not change. After 1 h of HCG administration the amplitude of contraction began to decrease and the frequency began to increase after 3 h. After about 5 h the changes in amplitude and frequency were generally fully developed. This pattern of myometrial activity persisted throughout the recording period (12 h) and was also present in recordings made after 24 and 48 h of HCG injection. A maximal increase in plasma progesterone concentration (5.0 ng/ml) had already occurred by 2 h after the HCG injection and gradually decreased thereafter. It is concluded that an elevation in the level of progesterone in non-pregnant rabbits resulting from increased ovarian output (through HCG) has a pronounced and immediate depressing effect on the character of myometrial activity which is indicative of a shift from nonpregnant to pregnant type.

Animals↗
PubMed1979

Prostaglandin-induced luteolysis in pregnant and pseudopregnant rabbits and the resultant effects on the myometrial activity.

The effect of prostaglandin (PG)-induced luteolysis on the myometrial activity in 20--21-day-pregnant and 11--12-day-pseudopregnant rabbits was studied by intrauterine pressure (IUP) recording during PG infusions. The same dose of PG (10 micrograms/h during 8h) was also given to 7 non-pregnant (untreated) does that were used as controls. Peripheral plasma concentration of progesterone and oestradiol-17 beta were measured at 2-h intervals during the infusion. Plasma progesterone level decreased significantly within 2 h or the start of infusion in pregnant and pseudopregnant does and continued to decrease; at the end of 8 h, the concentrations were 31 and 41%, respectively, of the pre-infusion levels. The amplitude of uterine contractions increased significantly after 4 h in pseudopregnant does, increased slightly but insignificantly in the pregnant does and showed no significant change in the non-pregnant does during PG infusion. The amplitudes developed in the pregnant and pseudopregnant does were significantly different. The direct effect of progesterone (1--3 micrograms/h during 4 h) was also studied in 7 non-pregnant rabbits. After 2 h the amplitude of contractions had decreased markedly and the pattern of activity had become irregular. The results support the concept of a myometrial inhibitory factor other than progesterone in rabbit pregnancy and suggest that this factor(s) originates in conceptus.

Animals↗
PubMed1979

[Effects of labour on parameters of carbohydrate and fatty acid metabolism in blood (author's transl)].

The influence of several types of uterine contractility in labour on the essential compounds of carbohydrate and lipid metabolism was studied. It has been concluded that the quality (type) of uterine activity is the defnite factor of the dynamic changes of free fatty acids concentration and of the proportions between the aerobic and anaerobic metabolism carbohydrates. The results obtained are discussed.

Blood Glucose↗