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Biomedical subjects

T Lebreton de Vonne

Publications and source records attributed to T Lebreton de Vonne.

17 recordsLinked to original sources
PubMed1997

Evolution of grass-cutter (Thryonomys swinderianus) inflammation markers: comparison with rabbit (Oryctolagus cuniculus) and rat (Rattus norvegicus).

An inflammatory reaction was induced in grass-cutters (Thryonomys swinderianus) by injecting turpentine. The changes in the plasma haptoglobin, fibrinogen, alpha 2 macroglobulin and immunoglobulin G was followed for 23 days by immunonephelometry. The results were compared to rat and rabbit. They showed that (a) the inflammatory reaction is delayed in the grass-cutter compared to rats and rabbits; (b) the concentration of haptoglobin increases less than in rat and rabbit; (c) the fibrinogen concentration is very low in the grass-cutter, despite hypercoagulability of blood; (d) the changes in the plasma alpha 2-macroglobulin in the grass-cutter seems to be comparable to that of rabbit alpha 1 macroglobulin in amplitude and in its slow return to the initial concentration; and (e) fibrinogen and haptoglobin are suitable markers for grass-cutter inflammation monitoring.

Animals↗
PubMed1989

Erythrocyte and plasma cholesterol exchange in sickle cell anemia.

The effects of sickling on cholesterol exchange between red cell membranes and serum lipoproteins were studied by following the movement of tritiated cholesterol incorporated into erythrocytes. The initial rate of this exchange was greater in sickled cells than in normal cells. One quarter of the cholesterol in the sickled cells is quickly exchanged with plasma lipoproteins. After 15 minutes, the rate becomes identical for these two types of cells, reaching similar equilibrium at end. The sickling of red cells would explain the observed differences, although conditions of hypoxia and the saturation of the incubation medium with oxygen tend respectively to accentuate and to cancel this phenomenon.

Anemia, Sickle Cell↗
PubMed1986

Modifications in plasma levels of alpha macroglobulins and fibrinogen trypsin perfusion in normal rabbits and in rabbits in acute phase reaction.

During trypsin perfusions in normal rabbits and in rabbits in acute phase reaction (APR), there is no modification in cardiorespiratory functions except in the instant preceding death. The fibrinogen level decreases and fibrin is deposited in the vascular lumen. The alpha 2 macroglobulin (alpha 2 M) content diminishes more rapidly than the alpha I macroglobulin (alpha I M) content; moreover, in subjects in APR, the decrease of alpha I M is further slowed with increasing perfusion rates, whereas the decrease in alpha 2 M remains constant. All the alpha M are completely combined at death. Therefore, it can be assumed that only the hepatic filtering of the alpha I M enzyme complex is subject to saturation.

Animals↗
PubMed1979

A study of rabbit plasma progressive antithrombinic activity during acute phase inflammatory reaction and in experimental nephrotic syndrome.

1. The development of the progressive antithrombinic activity in rabbit plasma as a function of the level of the two alpha-macroglobulins in two experimental pathologies: acute phase inflammatory reaction and nephrotic syndrome, were studied. 2. In the first case, the antithrombinic activity is a result of the increased biosynthesis of plasmatic antithrombins: antithrombin III, alpha 1 antitrypsin and alpha macroglobulins. 3. In the nephrotic syndrome, this activity follows the increase in the alpha M levels, the other antithrombins having been massively eliminated from the circulation in the urine.

Animals↗
PubMed1978

[Progressive antithrombin activity in rabbit plasma. Role of alpha macroglobulins].

Immunological methods associated with a kinetic study of blood coagulation allowed us to show the influence of the 2 rabbit alpha macroglobulins on the plasma progressive antithrombin activity. This study allowed the authors to discuss the participation of the alpha macroglobulins during the fibrinoformation and to think that these proteins have an immediate antithrombin activity.

Animals↗