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Biomedical subjects

T M Aaberg

Publications and source records attributed to T M Aaberg.

At least 91 records · Page 5Linked to original sources

Laser photocoagulation in the acute retinal necrosis syndrome.

Acute retinal necrosis (ARN) is a syndrome of fulminant necrotizing vaso-occlusive retinitis associated with a high incidence of retinal detachment due to retinal breaks and vitreous traction. We performed argon or krypton laser photo-coagulation to demarcate areas of active retinitis as prophylaxis against retinal detachment in five patients with ARN. Patients were concomitantly treated with antiviral agents, systemic steroids, and antiplatelet therapy. One patient required multiple additional treatments as retinal necrosis progressed. The retinas remained attached in all five patients over a mean follow-up period of 15 months. By creating a chorioretinal adhesion in areas of potential retinal break formation, laser photocoagulation may be an effective prophylaxis against retinal detachment in ARN.

Acute Disease↗

Effect of silicone oil on experimental traction retinal detachment.

The use of silicone oil as a retinal tamponade in the treatment of proliferative vitreoretinopathy is often complicated by membrane reproliferation. We studied the development of traction retinal detachments following the intravitreal injection of 15,000 retinal pigment epithelial cells in silicone-, perfluoropropane-, and fluid-filled rabbit eyes. By 28 days a higher proportion of silicone-filled eyes (83%) had severe proliferative vitreoretinopathy than either the perfluoropropane-filled (30%) or fluid-filled (10%) eyes. An in vitro proliferation assay using the vitreous samples showed that the silicone-filled vitreous had increased mitogenic activity for retinal pigment epithelial cells compared with the gas-filled or fluid-filled vitreous. Silicone oil appears to increase proliferation by stimulating the release of more or different mitogenic factors as well as by concentrating active factors into a smaller volume near the retina.

Animals↗

Changing indications and techniques for vitrectomy in management of complications of diabetic retinopathy.

During the past two decades, the number of diabetic patients requiring vitrectomy for nonresolving vitreous hemorrhage has decreased four-fold, whereas there has been a substantial increase in diabetic patients with traction and combined traction/rhegmatogenous retinal detachment (RD) requiring surgery. Additional contemporary surgical indications are progressive fulminant neovascular proliferation, massive preretinal hemorrhage, massive fibrin response, and progressive retrolental fibrovascular proliferation. Surgical techniques for management of tractional detachments have evolved from circumscription of tractional epicenters to en bloc removal of all proliferative tissue.

Diabetic Retinopathy↗

Surgical management of idiopathic epiretinal membranes.

The authors reviewed 33 consecutive cases of idiopathic epiretinal membranes removed by vitreous surgical techniques. Visual acuity improved in 79% of surgically treated eyes. In uncomplicated cases, a 47% gain in visual acuity was achieved. Of those eyes that had improved visual acuity post-operatively, 82.5% of the final visual acuity returned by four to eight weeks post-operatively. Eyes with opaque membranes had visual acuity results no worse than those with translucent membranes. Eyes with no pre-operative cystoid edema had better visual acuity results than eyes with cystoid macular edema (CME), although no statistically significant difference was shown. Surgical removal of membranes decreased fluorescein dye leakage in 30% of eyes; while no change in post-operative leakage was noted in 60%, one eye had increased CME post-operatively. Complications included development of nuclear sclerotic cataract, retinal breaks, retinal detachment, and one case of pigment epithelial/retinal burn from the endoilluminator, residual and recurrent membrane formation, and anterior ischemic optic neuropathy.

Adult↗

Recurrences and bilaterality in the multiple evanescent white-dot syndrome.

Multiple evanescent white-dot syndrome recurred in two men (23 and 44 years of age, respectively). One patient had a recurrence in the previously affected eye three years after the initial visual loss; the other patient had two recurrences in the contralateral eye, each separated by two years. Two additional patients (a 28-year-old woman and a 21-year-old man) had bilateral but asymmetric acute involvement. Computerized visual study showed a loss of retinal sensitivity in both eyes, correlating poorly with the clinically observed lesions. Results of electro-oculography were abnormal in the patients with bilateral involvement; results of electro-retinography were abnormal only in the more severely involved eye. Systemic investigation in the two bilateral cases was unrevealing. None of the four patients had experienced a preceding influenza-like illness and all had complete recovery of vision within four to six weeks.

Adult↗

Optic disk findings in hypervitaminosis A.

Three cases of papilledema secondary to chronic excessive vitamin A intake are presented, and the optic disk changes are documented with intravenous fluorescein angiography. Two of the three patients reported in this study were symptomatic with blurred vision and systemic complaints. The symptoms of blurred vision and systemic complaints disappeared within one week, and papilledema resolved over several months after discontinuance of vitamin A. The fluorescein angiographic changes observed in the optic disk of patients with hypervitaminosis A are similar to those associated with other known causes of papilledema. Since vitamin A is a nonprescription drug, and its indiscriminate use is potentially great, any history of vitamin ingestion should be elicited during the evaluation of papilledema.

Adult↗

Posttraumatic endophthalmitis.

Nineteen consecutive cases of culture-proved posttraumatic endophthalmitis occurred. Over an eight-year period, 19 (7.4%) of 257 patients with penetrating trauma had endophthalmitis develop, and 19 (31.1%) of 61 cases of endophthalmitis were due to trauma. Eleven (10.7%) of 103 patients with intraocular foreign bodies had endophthalmitis develop. Final visual acuity was 20/200 or better in eight (42.1%) of 19 and 20/30 or better in five (26.3%) of 19 cases of posttraumatic endophthalmitis. Organisms cultured were similar to those in the other types of endophthalmitis, except that Bacillus species were seen only in posttraumatic endophthalmitis (five [26.3%] of 19). Virulent organisms or retinal breaks or detachments seen at the time of primary repair indicated poor prognoses.

Adolescent↗

Choroidal granuloma in sarcoidosis.

We examined two patients--a 33-year-old black man and a 62-year-old white woman--who had pale yellow choroidal tumefactions with subretinal fluid and reduced vision. One patient had a history of granulomatous iritis; both patients were initially thought to have metastatic choroidal carcinoma. Systemic investigation yielded positive tissue diagnosis for sarcoidosis, leading to the diagnosis of presumed sarcoid choroidal infiltration. There was striking absence of inflammation of the retina, retinal vessels, and vitreous cavities. Fluorescein angiography disclosed initial hypofluorescence and late hyperfluorescence and ultrasonography demonstrated medium internal reflectivity. Neither study could exclude metastatic choroidal carcinoma. One patient had an increased level of angiotensin-converting enzyme on serial determinations through 15 months of observation and during treatment with corticosteroids, indicating a good correlation with improved vision and flattening of the choroidal granuloma. In both cases there was only partial resolution of the choroidal granuloma with corticosteroids. We conclude that choroidal granuloma can be the sole ocular manifestation of sarcoidosis and in this context is likely to be confused with metastatic choroidal carcinoma. We also believe that biopsy confirmation is needed because noninvasive tests such as gallium scans and angiotensin-converting enzyme cannot be relied on for diagnosing sarcoidosis and excluding carcinoma.

Adult↗

Intraocular argon laser photocoagulation in the management of severe proliferative vitreoretinopathy.

We surgically repaired seven eyes with severe proliferative vitreoretinopathy with intraocular argon laser photocoagulation. Five of the seven retinas were still attached six or more months postoperatively. Endolaser photocoagulation was used in conjunction with pars plana vitrectomy, periretinal membrane stripping, fluid-air exchange, and planned retinotomies. The advantages of endolaser photocoagulation include easier management of posterior retinotomies in an air-filled eye, isolation of anterior traction and retinal breaks by creating an encircling demarcation line posterior to the problem, and less manipulation of existing scleral buckling material.

Adult↗

Serous choroidal detachment after retinal detachment surgery.

In a prospective evaluation of 154 consecutive retinal detachment procedures, the incidence of choroidal detachment was 39.6%. The age of the patient, drainage of subretinal fluid, and vortex compression by the explant seem to be the most important correlative factors. Scleral explants up to one quadrant in circumferential length produced a minimal incidence (7.7%) of choroidal detachment. Posterior positioning of the explant also affected the incidence of choroidal detachment. After follow-up, ranging from six to 48 months, postoperative visual acuity was recorded for "macula-on" as well as "macula-off" retinal detachments. In the macula-on group, 78.6% of the patients with choroidal detachment retained a visual acuity of 20/50 or better compared with 82.8% of the patients without choroidal detachment. In the macula-off group, 43.2% of the patients with choroidal detachment achieved a visual acuity of 20/50 or better compared with 55.1% of the patients without choroidal detachment. The final anatomic success rate was 86.5% for eyes with choroidal detachment and 92.3% for eyes without choroidal detachment.

Age Factors↗