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Biomedical subjects

T M Aaberg

Publications and source records attributed to T M Aaberg.

At least 109 records · Page 6Linked to original sources

Digital subtraction angiography in the diagnosis of retinal vascular disease.

Digital subtraction angiography is a safe, inexpensive method of investigating systemic vascular disease in patients for whom conventional carotid angiography is too risky. We used this technique in five patients with a variety of retinal vascular conditions--a 55-year-old woman with occlusion of the right internal carotid artery, a 63-year-old man with bilateral occlusion of the internal carotid arteries, a 72-year-old man with occlusion of the stem of the left subclavian artery and an irregularity of the proximal portion of the innominate artery, a 77-year-old man with optic nerve head neovascularization and stenosis of the left internal and external and right internal carotid arteries, and a 74-year-old man with recurrent stenosis of the left internal carotid artery. In all five cases, digital subtraction angiography was helpful in determining the diagnosis and course of treatment.

Aged↗

Macular hamartomas of the retinal pigment epithelium and retina.

Four patients with macular hamartomas of the retinal pigment epithelium and retina are described. Associated choroidal neovascularization was noted in one patient. The clinical, fluorescein angiographic, and histopathologic findings of this entity are reviewed.

Adolescent↗

Advanced diabetic retinopathy: surgical treatment of complications.

Visual loss from the complications of advanced diabetic retinopathy now can be managed more effectively by surgical vitrectomy with a significant reduction in operative and postoperative ocular morbidity. Ocular structures are now maintained in a more normal physiologic state, leaving the patient's lens in place, helping to reduce postoperative glaucoma.

Diabetic Retinopathy↗

Recurrent clinical uveitis. Cell surface markers on vitreous lymphocytes.

The cell surface characteristics of vitreous mononuclear cells were determined in ten eyes with chronic idiopathic uveitis. Most of the cells had surface immunoglobulin, some exhibited phagocytosis; few formed E rosettes. This result suggests that most of the cells found in the vitreous of eyes with chronic idiopathic uveitis are B cells and macrophages; few T cells are present.

Adolescent↗

Ocular and systemic manifestations of the Bardet-Biedl syndrome.

Four women with the Bardet-Biedl syndrome had ophthalmoscopic findings compatible with a severe rod-cone degeneration. The patients were legally blind (visual acuity, 20/200 or worse) in one or both eyes before the age of 30 years. Two patients with early involvement had macular bull's-eye pigment epithelial changes. Two other patients had more advanced disease with geographic atrophy of the macular pigment epithelium and underlying choriocapillaris. Bone spicule formation was variable. Electrophysiologic findings were consistent with severe derangement of both the rod and cone systems. All four patients had intraretinal capillary leakage along the vascular arcades and from the optic nerve without cystoid macular edema. Extensive endocrinologic evaluation showed no objective evidence of hypogenitalism in the three patients tested. Three patients had renal disease, secondary to vesicoureteral reflux, or hypertension, or both.

Adolescent↗

A pars plana filtering procedure combined with lensectomy and vitrectomy for neovascular for neovascular glaucoma.

In 14 eyes undergoing a pars plana filtration procedure combined with pars plana lensectomy and vitrectomy, the most common complication was a severe sterile fibrinous vitritis. However, after a mean follow-up period of 6.3 months, intraocular pressure was controlled in five eyes (36%) after the procedure alone, in two (14%) after subsequent medical therapy, and in three (21%) after subsequent cyclocryotherapy. Preoperative visual acuity was maintained or improved in nine of the eyes (64%), whereas four eyes (28%) had no light perception.

Cryosurgery↗

Surgical results in ocular trauma involving the posterior segment.

Of 106 eyes with trauma involving the posterior segment, 12 could not be repaired, 74 were treated with vitrectomy, and 20 without vitrectomy. Fifty-five eyes (52%) achieved functional success (defined as a final visual acuity of 6/30 [20/100] or better or as a postoperative improvement in visual acuity from light perception or worse to 6/240 [5/200] or better), 16 (15%) attained anatomic success (attached retinas and generally clear media) but were functional failures, and 35 (33%) were both anatomic and functional failures. The prognosis was better in cases with intraocular foreign bodies and worse in cases with retinal detachments, marked vitreous hemorrhage, and large scleral lacerations. Traumatic involvements of the lens did not appear to affect the prognosis. Prophylactic scleral buckling appeared to lessen the incidence of postoperative retinal detachment. The eyes that underwent vitrectomy within 14 days of the injury had a better final visual outcome than those that underwent later vitrectomy.

Adolescent↗

Pars plana vitrectomy for diabetic traction retinal detachment.

One hundred twenty-five consecutive cases of traction macular detachment secondary to diabetic retinopathy are analyzed. Visual results show 72% to have improvement. Long-term follow-up (average 39 months) of the initial 75 cases revealed that 62% of the initially improved cases remained improved. Neovascular glaucoma rate continues to be higher in aphakic eyes as compared to phakic eyes.

Adult↗

Reclassification of intraocular reticulum cell sarcoma (histiocytic lymphoma). Immunologic characterization of vitreous cells.

Systemic and orbital reticulum cell sarcomas (RCSs) have been shown to be derived from lymphocytes, not reticulum cells or histiocytes, by immunologic and cytochemical characterization. Unfortunately, until now it has not been technically possible to study intraocular RCS. We have been able to immunologically characterize a primary intraocular RCS in a patient with chronic lymphocytic leukemia (ie, Richter's syndrome), establishing its origin from B lymphocytes. A review of the clinical course of such tumors indicates that primary intraocular non-Hodgkin's lymphoma is usually a manifestation of a systemic neoplasm of the immune system.

Adolescent↗

Pars plana vitrectomy techniques for relief of epiretinal traction by membrane segmentation.

We used a technique for surgical management of fibrovascular membranes to relieve epiretinal tangential traction when present in proliferative diabetic retinopathy. Sharp dissection with intraocular scissors was used to segment fibrovascular and cortical vitreous membranes together with cauterization of large vessels with intraocular bipolar diathermy. The objective of membrane segmentation was to relieve all epiretinal traction, thereby reducing retinal surface distortion and allowing the retina to flatten and reattach. Complete relief of traction prevented further late contraction of membranes and subsequent distortion and redetachment.

Air↗

Birdshot retinochoroidopathy.

Four patients, two men and two women ranging in age from 40 to 70 years, had birdshot retinochoroidopathy. The special features of this entity are diffuse posterior choroidopathy with associated vitritis and retinal vasculitis. Decreased central vision is caused by cystoid macular edema. In the early course of this disease, the cystoid macular edema may be responsive to corticosteroids. The diffuse choroidopathy is associated with abnormal retinal pigment epithelium and sensory retinal function on electrophysiologic testing. No previously described choroidal or retinal pigment epithelium diseases appear to resemble this entity.

Adult↗

Cystoid macular edema after retinal detachment surgery.

One hundred eyes in 98 patients were studied by fluorescein angiography and stereo color photography six weeks after successful scleral buckling surgery. Twenty-five percent of 67 phakic eyes and 40% of 33 aphakic eyes demonstrated cystoid macular edema. Older phakic patients were at significantly greater risk to develop cystoid macular edema than younger phakic patients. Seventeen percent of successfully repaired eyes demonstrated distortion of the macula by preretinal membranes; 16 of these 17 eyes showed leakage of fluorescein dye into the surrounding retina sometimes also causing cystoid edema. Either cystoid macular edema or macular distortion was present in 38% of the phakic eyes and 64% of the phakic eyes after successful retinal detachment surgery.

Edema↗

Intraretinal macrocysts in retinal detachment.

Seven cases of retinal detachment were associated with ophthalmoscopically visible macrocysts. These cysts were associated with long-standing retinal detachment, particularly of the traumatic type with retinal dialysis. They arose from the outer plexiform layer of the retina. In four cases, the macrocyst extended to the ora serrata. Most macrocysts require no specific attention during retinal detachment repair. If the cyst prevents closure of the primary retinal break, we advocate its surgical drainage. Four cases in the present series required surgical collapse of the macrocyst.

Adolescent↗

Rhegmatogenous retinal detachment complicating cytomegalovirus retinitis.

Six eyes in four patients with cytomegalovirus retinitis developed retinal holes and retinal detachment. Holes appeared in areas of necrosis and were typically large and round with shaggy edges. Differentiation from exudative detachment was sometimes difficult because of obscuration of the fundus by vitreous haze. Cryotherapy was successful in closing open breaks without detachment; cryotherapy and exoplant surgery were used effectively to treat the initial detachments. The occurrence of massive periretinal proliferation and late development of new areas of hole formation or retinitis complicated therapy for these detachments.

Adult↗

Clinical results in vitrectomy for diabetic traction retinal detachment.

A series of 75 eyes underwent pars plana vitrectomy for progressive diabetic traction retinal detachment of the macula. In all cases, the media was sufficiently clear to allow preoperative macular examination. The overall visual improvement was higher in phakic eyes (80%) than aphakic eyes (72%) and the rate of neovascular glaucoma was less in phakic eyes. The difference was not statistically significant, however. The final visual acuity corresponded to the degree of preoperative visual deterioration. Thus, surgery during the rapidly evolving proliferative and retracting process did not adversely affect the visual success rate when compared to previous reports on longstanding vitreous hemorrhage.

Aphakia, Postcataract↗

Natural history of serous detachments of the retinal pigment epithelium.

Fifty eyes of 40 patients with serous (avascular) detachments of the retinal pigment epithelium were followed up for an average of 22 months. Of the 50 eyes, 14 (28%) developed bleeding beneath the retinal pigment epithelium and retina or subretinal neovascularization detected on fluorescein angiography. These changes did not occur in eyes of patients younger than age 56 years at diagnosis or in detachments less than 1 disk diameter in size, whereas 35.9% (14) of eyes in patients older than age 56 years developed vascular complications. Vascular complications were uncommon when the initial detachment did not involve the fovea. Visual acuity declined in only one (9.1%) of eyes in patients younger than age 56 years but in 20 (51.3%) of eyes in patients age 56 years or greater.

Adult↗