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T M Kovalenko

Publications and source records attributed to T M Kovalenko.

22 records · Page 2Linked to original sources
PubMedDate not supplied

[Endothelium-dependent vascular response in rabbits during prolonged experimental hypercholesterolemia].

It was shown in experiments on anesthetized rabbits that disturbances in endothelium-dependent relaxant (Ach-induced) and constrictor (hypoxia-induced) vascular responses depended on duration of high hypercholesterol diet and on the structural damage of the vascular wall as well as on changes in the functional activity of endotheliocytes. Short (1 month) hypercholesterolemia led to thickening of the blood-cellular barrier and promoted a decrease in the endothelium-dependent relaxant response to Ach. At the same time short hypercholesterolemia enhanced a constrictor component of the vascular smooth muscle (VSM) response to hypoxia. It may be explained by a different degree in disturbance of synthesis and/or release of the endothelial relaxing and constrictor factors. At the later period of hypercholesterolemia (2-9 month) parallel with a pronounced damage of the endothelium and development of atheromatous plaques, the impairment of the endothelium-dependent vascular responses became more and more pronounced. As a rule, Ach-induced relaxation in VSM was registered in sole experiments only and very often was either absent or transformed to contraction. Constrictor components of vascular response to hypoxia were significantly decreased as well. The above-mentioned disbalance between endothelial relaxant and constrictor factors in combination with structural damage of the endothelium and difficulty in transendothelial transport of these factors to effector elements of the vascular wall may cause vasospastic reactions in VSM at atherosclerosis.

Acetylcholine↗
PubMedDate not supplied

[Antibacterial activity and clinical effectiveness of the new antiseptic miramistin].

A clinico-laboratory study of miramistin, a new antiseptic was carried out. Susceptibility of 236 bacterial strains to miramistin was tested and its therapeutic efficacy was followed up in 10 patients with purulent inflammatory affections of the locomotor system treated locally. After an 18-hour exposure of the strains to a 0.01 per cent solution of miramistin only 9.3 per cent of the isolates (mainly staphylococci) remained viable. Gram-negative cocci died in 6 hours and streptococci died in 1 hour. The local treatment of the wounds on the average for 14 days provided lower dissemination of the pathological foci. In the majority of the patients there was stated primary union of the wounds. On the whole, the results were good in 7 patients, satisfactory in 2 patients and unsatisfactory in 1 patient. No side effects were recorded. Miramistin may be recommended as an antiseptic for the local treatment of infected wounds in traumatologic and orthopedic patients.

Anti-Infective Agents, Local↗