Ultrastructural study of rat mammary gland during pregnancy.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to T M Murad.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
A review of radiation-induced atypia is presented. The radiation changes are divided into acute, intermediate, and late. The presence of cancer cells following irradiation is divided into persistent carcinoma, early recurrent carcinoma, and late recurrent carcinoma. The features of each group are described, supplemented by illustrations depicting the changes. The cytologic changes of radiation are discussed by correlating the light microscopic features with the electron microscopic findings in 8 cases that were studied ultrastructurally.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
This study demonstrates the practical advantage of using more than one technique in evaluating breast tumors. Thionin stained, frozen sections and H & E stained, paraffin-embedded, permanent sections yielded a high degree of accuracy in differentiating benign from malignant lesions. Papanicolaou stain is essential for evaluating cytologic material. Special stains, enzyme histochemistry, and examination by SEM and transmission microscopy are essential in identifying the various cellular components of mammary tumors. On the basis of these techniques, fibroadenomas were defined as tumors of stromal cells of the lobule and sclerosing adenosis as a benign proliferation of myoepithelial cells; and it was suggested that mammary cancers may arise from myoepithelial ductal epithelial, or ductular epithelial cells. The behavior of the tumor is related to its cell of origin.
The cytologic changes of pregnancy and the postpartum period are presented. Atypical cells were identified in 12% of smears; the majority of these atypical cells were related to degenerating decidual cells. Cells thought to represent changes due to folic acid deficiency are also described, and the features that help separate decidual cells from other cell types in the genital tract are illustrated. True neoplasia, when present, tended to persist after delivery, and these cells should not be confused with pregnancy-associated atypia.