Biomedical subjects

T M Plotnikova

Publications and source records attributed to T M Plotnikova.

22 records · Page 2Linked to original sources

PubMedDate not supplied

[Effect of euphylline on the blood supply and functional activity of the brain in waking cats with experimental intracerebral hemorrhage].

Experiments on 26 conscious cats with experimental intrarebral hemorrhage showed that 24-48 hours after blood administration, intracarotid infusion of euphylline promoted EEG returning to normal, enhanced the local blood flow of the test structures of both hemispheres and produced hurried breathing without material changes in the systemic arterial blood pressure. Administration of the drugs in the later periods (days 7-8) was not effective and even produced a decrease in blood supply to the affected hemisphere. EEG tendency towards normal remains unchanged.

Acute Disease↗

PubMedDate not supplied

[The effect of cerebrocrast on the microcirculation in acute transient cerebral ischemia].

In experiments on rats with cerebral ischemia (30-min occlusion of carotid arteries), the novel calcium antagonist Cerebrocrast (0.4 microgram.kg-1.min-1 i.v. for 15 min) was found to provide the functional maintenance of the parietal cerebral bed in the postischemic period by improving cerebral hemodynamics, reducing the number of highly narrowed capillaries. The agent prevented the erythrocytic accumulation of lipid peroxidation (LPO) products (diene conjugates and Schiff bases) in the intra- and postischemic periods, promoted the maintenance of viscoelastic properties during LPO activation.

Acute Disease↗

PubMedDate not supplied

[The effect of ethomersol on local cerebral blood flow and edema of the brain tissue in chronic ischemia].

The effects of ethomersole (50 mg/kg orally during 10 days) on local cerebral blood flow and cerebral tissue impedance were investigated in rats after left carotid artery ligation and right carotid artery narrowing (blood flow was decreased to 50%). Under these conditions, ethomersole accelerated the blood flow recovery, levelled blood flow asymmetry between the hemispheres, decreased the development of brain edema. In in vitro experiments ethomersole demonstrated a pronounced limitation of cerebral lipid peroxidation.

Animals↗

PubMedDate not supplied

[The effect of cerebrocrast on erythrocyte function].

The new calcium antagonist cerebrocrast intravenously infused in a dose of 0.4 micrograms.kg-1.min-1 during 15 min prevented erythrocyte deformability disturbances at the end of cerebral ischemia in rats, which was induced by carotid artery occlusion during 30 min. The agents also prevented the deformability 1 hour after the onset of recirculation. Cerebrocrast reduced spontaneous erythrocyte aggregation, the strength of erythrocytic aggregates, and hemoglobin affinity for oxygen. The latter effect was associated with the drug-induced increase in erythrocytic 2,3-diphosphoglycerate levels.

Animals↗