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Biomedical subjects

T Miyamae

Publications and source records attributed to T Miyamae.

At least 109 records · Page 6Linked to original sources
PubMed1984

[Distribution of ethanolamine oleate after injection in esophageal varices].

The purpose of this study is to know the systemic distribution of sclerosant injected into esophageal varices. Sclerotherapy for esophageal varices was performed for 14 times in 11 patients. The patients were divided into two groups according to the content of sclerosant. Seven patients received a total of 9 intravariceal injections (IVI) with 7 to 30ml of 5% ethanolamine oleate (EO) which contained meglumine diatrizoate (Angiographin) and four patients received a total of 5 IVI with 10 to 20ml of 4.5% EO which contained a 10% volume of 99mTcO-4 solution (EO-99mTc). Distribution of injected materials was observed by X-ray fluoroscopy in the former group and by a scintillation camera in the latter. In both methods most of the sclerosant disappeared from the injected site within five minutes leaving a trace in the varices. Then, the sclerosant was disseminated throughout the body via portal vein. When more than 20ml of sclerosant was injected, some flowed into the azygos vin through the periesophageal vin. After IVI the varices showed atrophic changes, though the sclerosant did not stay in the varices.

Adult↗
PubMed1983

Invasion of avian encephalomyelitis virus from the gastrointestinal tract to the central nervous system in young chickens.

Invasion sites of avian encephalomyelitis virus in the internal organs of orally infected chicks were determined by the immunofluorescent method. The invasion began when the epithelium tunica mucosae of the duodenum (together with the proventriculus, jejunum, or cecum in certain birds killed at postinoculation day 1) became test-positive. Viremia persisted for more than 5 days in the early stage of infection, then the pancreas was rapidly infected, followed by the liver, kidney, and spleen. Subsequently, the virus spread to the CNS. Rapid infection of the duodenum and pancreas was clearly observable.

Animals↗
PubMed1982

Corynebacterium kutscheri invasiveness of the gastrointestinal tract in young mice.

Corynebacterium kutscheri invasiveness of the tissues of the gastrointestinal tract in mice was investigated by the fluorescent antibody technique. The invasion was clearly recognized in 3-week-old mice infected intragastrically along with gastric mucin and a subcutaneous dose of cortisone; 10(7) organisms caused a notable invasion of the gastric and duodenal tissues. Furthermore, marked bacterial invasion of the large intestine appeared in mice challenged perorally with 7 x 10(7) organisms.

Animals↗
PubMed1982

Ethylene oxide sterilization of medical devices--with special reference to the sporicidal activity and residual concentration of ethylene oxide and its secondary products.

For the sterilization of disposable medical devices, ethylene oxide gas is used in most cases. When this sterilization method is used, ethylene oxide (EO) and its secondary products, i.e., ethylene chlorohydrin (ECH) and ethylene glycol (EG), remain in the medical devices after sterilization. If their concentration is high, these residues are liable to cause hemolytic activity and dermal or mucous membrane irritability in the human body. For this reason, in 1978 the FDA announced a proposal to regulate the residual limits of EO, ECH and EG. Our studies were done to examine the conditions of EO sterilization from the viewpoints of the sterilization effect and the residual chemical substances and to find the optimum conditions for sterilization. Further, the aerator was fabricated for the exclusive purpose of reducing, within a brief period, the concentration of EO and other substances remaining in the medical devices after sterilization and we examined the condition of aeration by using this aerator. As the result, it was found that a satisfactory sterilization effect could be obtained under the sterilization conditions of an EO gas concentration of 500 mg/liter, a sterilizing temperature of 55 to 60 degrees C and a sterilizing time of two hours, and under these conditions the concentration of the residual substances such as the EO could be made comparatively lower. It was also clarified that the minimum required aeration conditions by using the exclusive-use aerator were a temperature of 55 to 60 degrees C and an aeration time of 24 hours and over.

Equipment and Supplies↗
PubMed1981

Evaluation of the commercial bacterial air samplers by the new bacterial aerosol generator.

Of late microbiological air samplers of various types have been developed in monitoring the critical areas in the hospitals and pharmaceutical plants. It has not been clarified, however, that a commercial air sampler is the most suitable for such a purpose. The present studies were conducted to investigate the bacterial collection efficiency of these air samplers. The new experimental apparatus basically consists of a bacterial aerosol generator and an isokinetic sampling steel air duct. Serratia marcescens was used as the test bacteria, and then the bacterial collection efficiency of the three kinds of commercial air samplers (Andersen air sampler, Pin-hole air sampler and M/G air sampler) was examined. It was found that in these experiments these three air samplers had a high bacterial collection efficiency. All except 0.3 to 2.0% of the small bacterial particles (1 to 5 micrometer) were trapped by these tested air samplers. Furthermore, in these three air samplers it was also confirmed that for collecting the hospital airborne bacteria the bacterial collection efficiency was more than 99.9%. The authors' findings showed that these three air samplers were designed according to Ranz and Wong's theoretical and experimental results.

Aerosols↗
PubMed1980

Horizontal transmission of a pancreas-passaged avian encephalomyelitis virus in chicks.

Pancreas-passaged avian encephalomyelitis (AE) virus was transmitted horizontally in a group of 40 (1-day-old) chicks within 3 weeks after they were intermingled with two orally infected 1-day-old chicks. Viral antigen was detected in the pancreas of these contact-exposed chicks. After 5 weeks, contact-exposed chicks developed high titers against AE virus, but the chicks did not develop clinical signs of AE. The passaged virus could not be recovered from feces of six immunized chicks.

Animals↗
PubMed1979

[Scintigraphy].

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Arterial Occlusive Diseases↗