Biomedical subjects

T Mumme

Publications and source records attributed to T Mumme.

23 records · Page 2Linked to original sources

PubMedDate not supplied

[What factors influence the results of ACT when the indication limits are exceeded?].

AIM: The present study evaluates the results of ACT at the knee joint with transgression of the usual spectrum of indications and points out the possible limits of the method. METHODS: In 20 of a total of 71 patients the indication limits of ACT were exceeded. The clinical follow-up over two years was related to the localisation, size, adjacent cartilage, previous and additional operations and the quality of the transplanted chondrocytes. RESULTS: The average patient age at time of operation was 41.1 years (24 to 55 years). The average defect size was 7.9 cm (2) (3.75 to 14 cm (2)). In the analysed group outside of the indication limits of ACT half of the patients showed good or excellent results at clinical follow-up after 2 years. 10 patients, however, assessed the clinical situation as fair or poor. Within this group 5 patients showed a minimum of two lesions. In 6 patients the treated defect was not completely surrounded by an adjacent cartilage shoulder. In 7 cases the meniscus at the site of the lesion had been partially removed in a previous operation and osteoarthrosis or kissing lesions were detected in 4 cases. The persistent good cell quality had no negative influence on the postoperative results. CONCLUSION: The results after ACT are influenced by the adjacent cartilage shoulder, kissing lesions, previous meniscectomy and osteoarthrosis. This may limit the indications of the method.

Adult↗

PubMedDate not supplied

[Coxitis fugax--the beginning of Perthes' disease?].

We present the clinical case of a decennial boy with acute leftsided hip pain without appropriate trauma. The initial diagnosis of coxitis fugax was verified in this case with inconspicuous blood parameters and X-ray by a sonographically proven intraarticular effusion. An immediate magnet resonance imaging (MRI) study of the affected hip joint was done. Here, a complete "necrosis" of the proximal femur epiphysis was verified. With knowledge of these results, an immediate operation of the hip joint with a ventral capsule incision and consecutive intraarticular decompression was performed. A complete reperfusion of the femur head was evident in the MRI scan seven days postoperatively. In accordance with this clinical case report, we would like to point out the necessity for the immediate diagnosis of indifferent hip pain by means of MRI, especially for patients in the atypical "critical age" (> or = 8 years) for coxitis fugax. This is discussed under consideration of the possible aetiopathogenesis and the current literature.

Arthralgia↗

PubMedDate not supplied

[Isolated bilateral Sternocostoclavicular Hyperostosis (SCCH) with a pathological clavicular fracture--a 10-year follow-up].

The presented case demonstrates the clinical and radiological course of a woman suffering from bilateral sternocostoclavicular hyperostosis (SCCH) from early changes to a spontaneous clavicula fracture after 10 years. SCCH is characterised by a chronic recurrent painful swelling of the sternoclavicular region due to an aseptic inflammation and hyperostosis of the clavicula, sternum, upper ribs and the adjacent soft tissues. Frequently the picture is accompanied by cutaneous and other skeletal symptoms. The disease can be part of the SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome. The chronic process is represented by the typical "bull horn sign" in a bone scan. NSAIDS should represent the first line treatment.

Anti-Inflammatory Agents, Non-Steroidal↗

PubMedDate not supplied

[First clinical experiences with a novel 3D-collagen gel (CaReS) for the treatment of focal cartilage defects in the knee].

AIM: In this prospective study we present a novel technique of matrix-based chondrocyte transplantation for the treatment of focal cartilage defects. METHOD: 22 patients with chondral or osteochondral femoral defects were treated with 3D-collagen type-I gel seeded with autologous chondrocytes (CaReS). Overall handling of this novel method is described, and results after 2 years follow-up with regard to the ICRS-score are presented. RESULTS: 14 patients were treated because of a focal chondral lesion, in 8 cases subchondral bone had to be reestablished. The average defect size was 6 cm(2). In all cases cell-seeded matrix samples could be fixed with fibrin glue without any problems. The average surgery time was 69 min, length of the surgical approach was 8.2 cm. No surgery-specific problems had to be observed. A significant improvement in IKDC-score, functional score and overall rating after 3 or 6 months up to 2 years follow-up was detected. After 2 years post-OP 13 Patients were evaluated and matrix-based defect treatment by CaReS was rated good to excellent by 84.6 % of the patients. CONCLUSION: Defect treatment with cell-seeded 3D-collagen gel is easy to handle with a good clinical outcome after 2 years follow-up. Further investigations with higher patient number, longer follow-up time and histological and biomechanical sample analysis are needed in order to establish this method as an improvement of conventional ACT.

Adolescent↗

PubMedDate not supplied

[Cemented total knee arthroplasties].

INTRODUCTION: The aseptic loosening of cemented total knee arthroplasties is still an unsolved problem. In this regard, the hydrolysis resistance in the metal-to-bone cement interface is of major importance. MATERIAL AND METHODS: Cemented pre-treated tibia components coated by means of a silica/silane interlayer system of the model "Columbus PS" were dynamically loaded with the help of a knee-simulator similar to DIN ISO 14243. After loading, the components were microscopically analysed concerning debonding in the metal-to-bone cement interface as well as with regard to cement mantle defects. These data were matched with uncoated "Columbus PS" components. Unloaded coated and uncoated tibia components acted as a control. RESULTS: In comparison with uncoated tibia components, the pre-treated and coated ones yielded a highly significant reduction of cement defects (p < 0.01) as well as a significant reduction of debonding in the metal-to-bone cement interface (p < 0.05). CONCLUSION: By means of the silica/silane interlayer system for cemented tibia components, a hydrolytic debonding in the metal-to-bone cement interface with subsequent mechanical loosening and consecutive early cement mantle failure can be significantly reduced. This could lead to an increased long-term stability of the metal-to-bone cement compound with decreased aseptic loosening in clinical use.

Adhesiveness↗