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Biomedical subjects

T Nash

Publications and source records attributed to T Nash.

At least 55 records · Page 3Linked to original sources
PubMed1989

Hypothyroidism: effect on warfarin anticoagulation.

Although our observation is not the first case of reduced PT response to oral anticoagulants associated with hypothyroidism, it is the only such interaction reported since 1963, and the first case involving warfarin therapy in a human being. We submit this case as a reminder of a potentially forgotten interaction, and to stress the importance of close monitoring in patients receiving warfarin therapy who have concomitant changes in thyroid function.

Administration, Oral↗
PubMed1988

Effect of antischistosomal chemotherapy on prevalence of Symmers' periportal fibrosis in Sudanese villages.

Almost all mortality caused by Schistosoma mansoni is secondary to Symmers' periportal fibrosis of the liver which can now be diagnosed by ultrasonography. This study assessed the usefulness of ultrasonography in measuring the effect of chemotherapy on the prevalence of Symmers' periportal fibrosis in Sudanese villagers. The prevalence of Symmers' fibrosis in 318 randomly selected patients from two villages not receiving systemic antischistosomal chemotherapy was compared with that in 168 patients from a village where antischistosomal chemotherapy had been systematically applied since 1979. The prevalence of Symmers' fibrosis was two to three times lower among treated villagers, with an eight-fold difference for villagers aged 10-20 years.

Adolescent↗
PubMed1988

Morbidity associated with Schistosoma mansoni infection as determined by ultrasound: a study in Gezira, Sudan.

Previous studies demonstrated the usefulness of ultrasonography in diagnosing Symmers' periportal fibrosis. The prevalence and grade of Symmers' fibrosis was determined using ultrasonography in two villages in the Gezira region of Sudan and compared to standard clinical criteria. In El Dar 18% and Abu Jin 13% of the population had Symmers' fibrosis by ultrasonography. In contrast, only 6.3% in El Dar and 5.2% in Abu Jin with Symmers' fibrosis had splenomegaly, thus most of the population with Symmers' fibrosis would not have been diagnosed clinically. The degree of involvement was estimated by a set of previously defined criteria which ranged from mild (grade 1) to severe (grade 3). Involvement was greatest between 20-30 years and followed the age peak egg excretion rate by 5 years. The prevalence and degree of splenomegaly as well as the portal and splenic vein diameters increased with grade. The presence of hepatomegaly did not correlate with increasing grade. Ultrasonography is a much more sensitive technique than clinical evaluation in estimating the degree of Symmers' fibrosis in this population. A more accurate assessment of involvement will allow a more rational approach to the study of the pathophysiology of this complication and its eventual control.

Adult↗
PubMed1987

Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes.

A number of rat monoclonal antibodies of the IgG2b subclass have been used to deplete mice of T lymphocyte subsets. It has been possible to produce long-term depletion where antibodies are administered to mice thymectomized in their adult life, or short-term depletion in euthymic animals. It is therefore feasible to ablate a T lymphocyte subpopulation at any stage in the course of an immune response and to examine in detail the role of a particular subset in the induction or effector phases of that response. We have used such ablative procedures to define the T cell subsets which participate in graft rejection, graft-versus-host disease, antigenic competition and antiviral and anti-self immunity and have attempted to exploit such knowledge to establish immunological tolerance in an adult animal.

Animals↗
PubMed1985

Interaction of Schistosoma japonicum with Salmonellae and other gram-negative bacteria.

The in vitro and in vivo interaction of Schistosoma japonicum with salmonellae and other gram-negative bacteria was studied. In vitro, S. japonicum associated with salmonellae and other gram-negative bacteria, and more male than female schistosomes associated with the bacteria. By using the various strains and mutants of salmonellae, we showed that Salmonella typhimurium had a higher degree of association than did Salmonella enteritidis and that the piliated strains of S. typhimurium associated much more frequently than did the nonpiliated strains. However, in vivo studies demonstrated more frequent association of salmonellae with female than with male schistosomes and that the piliated and nonpiliated strains of salmonella did not differ in their association with the worms.

Adhesiveness↗