PubMed Health⌕ Search

Biomedical subjects

T Seeman

Publications and source records attributed to T Seeman.

At least 91 records · Page 5Linked to original sources
PubMed1980

Structural and functional changes in ribosomes from ischemic liver in the dog: effects of short-term hepatic artery ligation and hemorrhagic shock.

Structure and function of isolated liver ribosomes from 10 dogs subjected to 1 h of hepatic artery ligation (HAL) or hemorrhagic shock were studied. A shift of polyribosomes to monoribosomes and a decreased capacity to incorporate amino acids into proteins were seen in both experimental conditions. The effects were more pronounced in hemorrhagic shock. Both structural and functional changes were reversible after HAL. In the shock experiments a slight increase of the ribosomal activity was seen after reinfusion but the initial values were not reached during the 2 h after the shock period. Some of the underlying mechanism of altered ribosomal structure and function in liver ischemia are discussed.

Amino Acids↗
PubMed1980

Priapsim: evaluation of treatment with special reference to saphenocavernous shunting in 26 patients.

In the past, idiopathic priapism was not treated at all or was conservatively managed by measures including aspiration and irrigation of the corpora cavernosa. Restoration of erectile function rarely resulted. Various venous bypass procedures have been tried since Grayhack, McCullough, O'Connor & Trippel in 1964 described the technique of saphenocavernous shunting in idiopathic priapism. Over a ten-year period 31 instances of priapism were seen in 30 patients. In 26 cases the priapism was classified as idiopathic. Saphenocavernous shunting was done in these 26 patients. At follow-up seven of them were potent. Our data indicate that alcoholism may be an aetiologic factor in idiopathic priapism, since 15 of the 26 men had a history of massive alcohol consumption. Idiopathic priapism should be regarded as a surgical emergency, and a venous shunt should be performed.

Adult↗
PubMed1980

Postoperative wound infections--a prospective study in a newly opened hospital.

The rate of postoperative wound infections was determined in a prospective study during one year in a newly opened University hospital. Protocols which were part of the routine care of the patients were used for recording of wound infections. This method of registration was simple and proved to be efficient with a failure rate of only 1%. The overall infection rate was 9%--after clean surgery 2.6%, potentially contaminated surgery 14% and contaminated surgery 16%. Old age, long preoperative hospital stay, emergency operations and long operative times were associated with high frequency of wound infections. The importance of continuous recording of wound infections in a surgical unit was emphasized.

Adolescent↗
PubMed1980

Torsion of the testis--a misinterpreted diagnosis in the young adult.

Torsion of the spermatic cord is fairly common even in young adults but is too often misdiagnosed. The anatomical anomaly and clinical features of 31 cases are reviewed. If a patient is operated upon within 10 hours of the onset of symptoms the testis will usually survive. In most patients a basic deformity that permits torsion is present on both sides of the scrotum. A plea is made for early diagnosis and bilateral fixation of the testes in all patients with a suspicion of torsion.

Adolescent↗
PubMed1979

Amino acid incorporation into liver proteins during hemorrhagic shock in the dog.

Liver protein synthesis was studied with an in vitro method during and after 1 h of hemorrhagic shock in the dog. Protein synthesis was significantly decreased already 15 min after induction of hypovolemia and was about 50% of the initial value at the end of the shock period. 2 h following retransfusion, protein synthesis was normalized. Some of the underlying mechanisms leading to decreased protein synthesis in hemorrhagic shock are discussed. Serum concentrations of liver enzymes were unchanged during the shock period indicating that the liver metabolism may be affected without changes in parameters often used to evaluated liver function.

Alanine Transaminase↗
PubMed1979

The extent of muscle tissue damage following missile trauma one, six and twelve hours after the infliction of trauma, studied by the current method of debridement.

Spherical missiles with velocities around 1000 m/s were used to inflict missile trauma to one thigh of pigs. The determination of the impact and exit velocities made it possible to calculate the extent of energy transferred to the tissue. About one third of the pigs were treated surgically within one hour after the trauma, one third after a delay of 6 hours and one third after 12 hours. The surgical procedure consisted of debriding muscle tissue which showed impaired contractility and/or consistency and discoloration and/or lack of capillary bleeding - the current criteria of non-viability. The amount of debrided muscle tissue from each wound was weighed and the amount of debrided muscle tissue per joule transferred to the tissue was calculated. As compared to operations performed within one hour the average of the debrided muscle tissue per joule was greater after 6 hours delay and even still greater after 12 hours. However, the difference between the averages after 6 and 12 hours were not statistically significant.

Animals↗
PubMed1979

Liver circulation and oxygen metabolism during short time ligation and the hepatic artery in the dog.

The changes of liver circulation and liver oxygen metabolism during and after one hour hepatic artery ligation (HAL) were studied in eight mongrel dogs. At the end of the HAL period total hepatic blood flow (THBF) was reduced from 115.6 +/- 5.5 ml/min . 100 g liver tissue to 68.0 +/- 3.7 ml/min . 100 g or 59% of the initial value. The portal venous blood flow was reduced from 83.1 +/- 3.4 to 58.8 +/- 3.7 ml/min . 100 or 82% of the initial value and the liver oxygen consumption was reduced from 4.1 +/- 0.2 ml/min . 100 g to 3.1 +/- 0.3 ml/min . 100 g or 76% of the initial value. The changes in portal venous blood flow and liver oxygen consumption were reversible following reopening of the hepatic artery. The clinical importance of a reduced portal venous blood flow and liver oxygen consumption following HAL and the possibilities to increase the portal venous blood flow are discussed.

Animals↗
PubMed1977

Circulatory disturbances following transient soft tissue compression trauma.

Circulatory changes following standardized compression trauma to the hind leg in dogs were evaluated using an electromagnetic flow meter and repeated angiography. A transient increase of flow to the injured limb and within the traumatized region was observed. Good agreement was found between the electromagnetic flow recordings and estimates of relative changes in flow by the angiographic method.

Angiography↗
PubMed1976

The haemodynamic effects of adrenergic receptor blockade or stimulation druing nitrous oxide anaesthesia in dogs.

The effects of ventilation with normoxic and hyperoxic nitrous oxide on systemic, pulmonary and coronary haemodynamics before and after adrenergic receptor blockade or stimulation were investigated in 15 dogs. To evaluate a blocking or stimulating effect of nitrous oxide on the alpha-adrenergic receptors, the animals were given phenoxybenzamine or noradrenaline, respectively. The effects of beta-adrenergic receptor blockade or stimulation were studied after injection of propranolol or isoproterenol, respectively. The experiments showed that in spite of the lack of alpha-receptor blocking properties and despite the tendency to produce beta-receptor blockade, nitrous oxide induced vasodilation. The findings of the present study, together with the increase in cardiac output and peripheral vasodilation, suggest that the cardiovascular effects of nitrous oxide are extra-adrenergic.

Anesthesia, Inhalation↗
PubMed1976

The haemodynamic effects of nitrous oxide anaesthesia on myocardial blood flow in dogs.

The effects of ventilation with nitrous oxide in oxygen on myocardial blood flow any oxygen metabolism were investigated in 31 mongrel dogs. The results of this study showed that, compared with controls, hyperoxic nitrous oxide mixtures did not cause any great changes in myocardial haemodynamics, despite a decrease in cardiac output and an increase in systemic vascular resistance. Normoxic nitrous oxide mixtures produced an increase of the coronary blood flow due to decreased coronary vascular resistance. To what extent this coronary vasodilatation resulted from a increased myocardial metabolism or from a direct effect of nitrous oxide on the coronary vascular bed cannot be quantified from the present results.

Anesthesia, Inhalation↗
PubMed1976

The haemodynamic effects of nitrous oxide anaesthesia on systemic and pulmonary circulation in dogs.

The haemodynamic effects of nitrous oxide in normoxia (20% oxygen) and in hyperoxia (50% oxygen) were investigated in 13 dogs. Nitrous oxide in hyperoxia caused a significant rise in total peripheral resistance and a significant decrease in cardiac output, heart rate, myocardial contractility (dP/dt max) and cardiac work. On the other hand, nitrous oxide in normoxia seemed to reverse these findings and did not exert negative inotropic effects on the myocardium. The results indicate that the earlier reported sympathetic activation of the circulation may be related to hyperoxia and not to nitrous oxide as such.

Anesthesia, Inhalation↗
PubMed1976

Inactivation of 5-fluorouracil by the liver during continuous regional and systemic infusion in pigs.

During continuous systemic or portal infusion of 5-fluorouracil (5-FU) to anaesthetized pigs, the cytostatic activity was reduced in blood traversing the liver. The liver eliminated between 15 and 50% of the amount 5-FU given per time unit. During jugular infusion the concentration of cytostatic compounds in portal blood was equal to or less than in systemic blood. The cytostatic activity was much higher in portal blood and lower in systemic blood during portal infusion. The findings speak in favour of portal infusions of 5-FU to patients with disseminated cancer in the liver.

Animals↗