Early changes in capillary flow and transport following missile wounds.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to T Seeman.
Explore the source record for details and available documents.
The immediate hemodynamic response to a high-velocity missile wound was studied in the hind legs of dogs. A spherical missile of constant mass and velocity was used. The immediate effect after the shot was a marked transient peak flow, which may be due to the effects of the pressure wave on the vascular bed, with a release of constrictor tone. The subsequent more constant increase of blood flow in the traumatized leg is of the same character as that seen following extensive soft-tissue contusion trauma. In addition to these local changes there was also a generalized effect with decreased blood pressure without a compensating increase in hear rate. This may be explained by the specific character of the trauma that a high-velocity missile produces.
A cross-infusion model including two dogs was used. At intervals 20 ml of blood from the iliac vein of one dog (donor), was injected during 60 sec into the iliac artery in which flow was measured electromagnetically in another dog (recipient). 1 min after missile trauma of the hind leg of the donor, the withdrawn venous blood possessed strong dilator property, manifesting itself by a transient, significant increase of blood flow in the registered artery of the recipient. This dilator property of venous blood from the traumatized region was, however, only apparent following wounding by missiles of high velocity.
The effects of repeated intraarterial injections of methylglucamine metrizoate on regional circulation were registered in soft tissue trauma to the dog hind leg. The circulatory disturbances were determined by hemodynamic measurements and by angiography. The changes of flow following injection of the contrast medium were related to the films. The informative arterial phase appeared in the time lag between injection and the flow increasing effect of the contrast medium both before and after trauma. No evidence of a cumulative effect was recorded.
The early circulatory changes following high velocity missile wounding to soft tissue of an extremity were analysed by hemodynamic methods and serial angiography. The extent of the tissue injury and the functional disturbances were mapped out and the time-course of the alterations in blood flow was registered. Possible mechanisms for the observed abnormalities are discussed.
The dilatation of major arteries following early after extensive soft tissue trauma was demonstrated angiographically not to be affected by pharmacologic or mechanical contractile stimuli. The proximal spread of the dilatation was not abolished by the division and a reanastomosis of the vessel before the trauma. These results suggest loss or impairment of the contractile ability of the major arteries following early after the trauma.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.