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Biomedical subjects

T Setogawa

Publications and source records attributed to T Setogawa.

At least 37 records · Page 2Linked to original sources
PubMed1993

Therapeutic efficacy of the benzoxazinorifamycin KRM-1648 against experimental Mycobacterium avium infection induced in rabbits.

The therapeutic efficacy of the benzoxazinorifamycin KRM-1648 was studied in an experimental rabbit infection system with avian Mycobacterium avium. The infected rabbits died from Yersin type infections, a peculiar type of experimental bovine tuberculosis characterized by a very rapid course, enlargement of the spleen and liver, and septic infection, 14 to 20 days after bacterial challenge, as evidenced by bacteremia and severe bacterial loads in the visceral organs. Histopathologic studies of the visceral organs of the infected rabbits revealed the development of numerous typical granulomatous lesions. This experimental rabbit infection system, features of which resemble certain features of disseminated M. avium complex infections in AIDS patients, was used to evaluate the therapeutic efficacy of KRM-1648, a newly synthesized benzoxazinorifamycin. KRM-1648 given orally at 25 and 50 mg/kg of body weight reduced the incidence and degree of bacteremia in infected rabbits and protected against subsequent death. Moreover, the drug allowed almost complete recovery of infected rabbits by week 7. KRM-1648 cleared infections in the lungs, liver, spleen, and kidneys and restored histopathologic features of healthy tissue in the visceral organs. KRM-1648 exhibited a more potent therapeutic effect against M. avium infection than rifampin and clarithromycin.

Animals↗
PubMed1993

Increased D-arabinitol/creatinine ratio in sera of patients with Behçet's disease during an active phase.

The ratios of D-arabinitol (a major metabolite of Candida species) to creatinine were examined in 46 sera of 40 patients with ocular inflammatory disease and in 50 age-matched normal controls (25 men and 25 women). The mean ratio in patients with endogenous Candida endophthalmitis was higher than in the normal controls. Seven samples taken from patients with Behçet's disease during an active phase showed higher values than in the controls. Fourteen patients with Behçet's disease in remission showed D-arabinitol/creatinine values within normal range. In four patients with sarcoidosis, in two patients with Vogt-Koyanagi-Harada disease, and in 16 patients with bilateral uveitis of an unknown cause, the ratios were within normal range. It is possible that D-arabinitol, or a metabolite of Candida species, may be related in part to the active phase of Behçet's disease.

Adult↗
PubMed1993

Psychiatric complications after ocular surgery.

Delirium was demonstrated after cataract surgery in a 64-year-old man (case 1). The patient struck his head against the floor; thereafter an extradural hematoma was found and extracted. Postoperative delirium was also noted in a 58-year-old woman (case 2) and in a 26-year-old woman (case 3) with rhegmatogenous retinal detachment. All 3 patients recovered from their psychiatric complications within 1 month.

Adult↗
PubMed1993

Patients with asteroid hyalosis and visible floaters.

Four patients with asteroid hyalosis who complained of seeing multiple spherical floaters were examined. Except for multiple brilliant particles in the gelatinous vitreous, no abnormalities were found by ophthalmoscopic examination. Asteroid bodies usually cause no visual symptoms in most patients. Therefore it is unusual that our patients with asteroid hyalosis perceived floaters. We concluded that it was because there had been no vitreous detachment so that the asteroid particles were located close enough to the retina to be perceived as floaters.

Aged↗
PubMed1993

A Japanese family with Grayson-Wilbrandt variant of Reis-Bücklers' corneal dystrophy.

A 50-year-old man (the proband) experienced recurring attacks of ocular irritation and had had bilateral ring-shaped anterior corneal opacity since adolescence. Corneal sensation was normal. The proband's 15-year-old daughter also had recurring episodes of ocular irritation and bilateral fleck-like anterior corneal opacities. The proband's deceased father and brother reportedly had similar corneal lesions from adolescence. We believe that the corneal findings in this family may be similar to those found in patients with the Grayson-Wilbrandt variant of Reis-Bücklers' corneal dystrophy.

Adolescent↗
PubMed1993

Chest x-rays before ophthalmic surgery.

We retrospectively reviewed clinical records and preoperative chest x-ray films of 636 patients who had been admitted for ophthalmic surgery in 1990 and 1991. In our hospital, a preoperative chest roentgenogram routinely was examined for each patient. A total of 228 patients (35.8%) had an abnormal preoperative result. These abnormalities were more frequent in patients older than 40 years of age than in younger patients. Pulmonary fibrosis and calcification were the most common abnormal findings. Also, we noted that 202 patients (31.8%) had a chronic, previously known, or suspected, finding, and 26 patients (4.1%) had a new or unsuspected finding. The surgery was postponed or canceled in five patients (0.8%) because of the abnormal x-ray results.

Adolescent↗
PubMed1993

Congenital cataract in the right eye and primary clinical anophthalmos of the left eye in a patient with cerebellar hypoplasia.

We examined a 26-year-old man who had an opaque lens OD and clinical anophthalmos OS. Low densities in the left cerebellar hemisphere and vermis and dilated ventricles were noted on a computed tomographic scan of his brain. We believe that the association of developmental cataract OD, clinical anophthalmos OS, and cerebellar hypoplasia in our patient may be rare.

Adult↗
PubMed1993

Pseudoretinitis pigmentosa in patients with systemic lupus erythematosus.

A 42-year-old woman and a 62-year-old man with systemic lupus erythematosus (SLE) had bilaterally mottled retinas with spots or clumps of pigment. Their electroretinographic responses were subnormal. Their fundi resembled those of patients with retinitis pigmentosa. The fundus lesions of our patients may have resulted from vascular occlusion associated with SLE.

Adult↗
PubMed1993

Nonpenetrating trauma in the right eye induces anterior uveitis and secondary glaucoma in the contralateral eye.

A 31-year-old woman was shot with a toy bullet OD. Intracameral cells and fibrin were found, but no penetrating wound was noticed. Flare was observed in the left anterior chamber three days after the incident, and the intraocular pressure OS had increased. No specific type of uveitis or systemic inflammatory disease was identified. We believe that bilateral uveitis was precipitated in our patient by the nonpenetrating trauma.

Adult↗
PubMed1993

Intraocular lymphoma invades the optic nerve and orbit.

A diagnosis uveitis OS was made in a 54-year-old woman; this was resistant to corticosteroid treatment. One year later, both eyes were involved. Examination of the vitreous aspirate and the results of a chorioretinal biopsy OD did not yield a correct diagnosis. Computed tomographic scanning showed orbital invasion OD. Malignant lymphoma was diagnosed after a biopsy specimen of the orbital contents was studied histopathologically. Radiotherapy and chemotherapy diminished the orbital mass and intraocular lesions. After regression of the orbital lesion, a brain tumor was found and treated with radiotherapy and chemotherapy. At age 57 years, the patient died. We believe that our patient had a rare case of intraocular lymphoma associated with orbital invasion.

Cranial Nerve Neoplasms↗
PubMed1993

[Behaviour of gamma delta TCR+ T cells during the course of nontuberculous mycobacterial infections and proliferative response of host lymphocytes to 65kD heat shock protein].

In order to know the possibility that gamma delta TCR+ T cells induced by Mycobacterium avium complex (MAC) infections participate in the expression of host resistance and in the occurrence of Behçet disease, we examined the behaviour of them in MAC-infected host mice. In both BALB/c (Bcgs; MAC-susceptible) and CBA/JN (Bcgr; MAC-resistant) strain mice, a transient but appreciable increase in the number of gamma delta TCR+ T cells in the host peritoneal lymphocytes was noted around week 1 to 2 after M. intracellulare infection via ip. route. The degree of induction of gamma delta TCR+ T cells was somewhat higher in CBA/JN mice than in BALB/c mice. Therefore, gamma delta TCR+ T cells are partly responsible for the expression of host resistance against the MAC in the early phase of infection. However, the subsequent decrease in the level of gamma delta TCR+ T cells was observed by week 5. Thus, in the case of chronic state of MAC infection, the size of gamma delta TCR+ T cell-pool seems to be in normal level. This suggests that per cell activity of gamma delta TCR+ T cells rather than mobilizing number of them is important factor in the mechanisms for occurrence of allergic diseases including Behçet disease. Although, the early increase in gamma delta TCR+ T cells of peritoneal cells was also observed during the course of M. fortuitum infection, the degree of induction of gamma delta TCR+ T cells in A/J mice (M. fortuitum-susceptible) was in similar level as that in BALB/c mice (M. fortuitum-resistant).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1993

Occlusion therapy of Japanese children with anisometropic amblyopia without strabismus.

We examined 38 children (20 boys and 18 girls) with anisometropic amblyopia without strabismus who had been treated with occlusion therapy. At the initial visit, their ages ranged from five to ten years. Their visual acuity scores improved after therapy, and this was unrelated to patient age. The amount of anisometropia, visual acuity at the initial visit, and compliance were related to improved visual acuity in the amblyopic eye. The visual acuity improved for six months after therapy. No further gains were detected thereafter.

Amblyopia↗
PubMed1993

Wasp sting-induced retinal damage.

A 36-year-old man was stung by a wasp OD. He became delirious and had dyspnea, ocular pain, and severely decreased visual acuity OD. A broken stinger was found in the central deep cornea. Additional ocular findings were keratitis, iritis, cataract, secondary glaucoma, and unrecordable electroretinographic responses.

Adult↗
PubMed1993

Central retinal vein occlusion in two patients with immunoglobulin G multiple myeloma associated with blood hyperviscosity.

A 69-year-old man (Patient 1) complained of anorexia, lumbago, and seeing floaters OS. The results of laboratory tests showed immunoglobulin (Ig) G lambda-type multiple myeloma associated with blood hyperviscosity. Retinal hemorrhages OD and central retinal vein occlusion OS were found. A 71-year-old woman (Patient 2) with IgG kappa-type multiple myeloma had blood hyperviscosity. Retinal microaneurysms OD and central retinal vein occlusion OS were found. We believe that our patients represent rare cases of IgG multiple myeloma associated with blood hyperviscosity and central retinal vein occlusion.

Aged↗
PubMed1992

Immunofluorescent staining and corneal sensitivity in patients suspected of having herpes simplex keratitis.

We examined immunofluorescent staining and corneal sensitivity in 25 control subjects (25 eyes) with normal corneas, six patients (eight eyes) with possible herpes simplex keratitis, and 44 patients (48 eyes) with corneal lesions (recurrent erosion, superficial punctate keratitis, marginal ulcer, and follicular keratoconjunctivitis) in whom herpes simplex keratitis was not suspected. On immunofluorescent staining, all 25 control subjects had negative reactions, all eight eyes suspected of having herpes simplex keratitis had positive reactions, and 11 (23%) of the 48 eyes not suspected of having herpes simplex keratitis had positive reactions; the remaining 37 eyes had negative reactions. Of the 11 eyes not suspected of having herpes simplex keratitis but that had positive reactions on immunofluorescent staining, nine had recurrent erosions and the remaining two eyes had superficial punctate keratitis. Of the eight eyes with possible herpes simplex keratitis, seven (88%) had decreased corneal sensitivity. Of the 11 eyes not suspected of having herpes simplex keratitis but that had positive reactions on immunofluorescent staining, eight (73%) had decreased corneal sensitivity. Of the 37 eyes not suspected of having herpes simplex keratitis that had negative reactions on immunofluorescent staining, 11 (30%) had decreased corneal sensitivity.

Adult↗
PubMed1992

Posterior chamber intraocular lens implantation in a patient with oculocutaneous albinism.

A 56-year-old woman with tyrosinase-negative oculocutaneous albinism complained of gradually decreasing vision in the left eye. Her visual acuity was 20/300 in the right eye and hand motion in the left eye. She had pink skin and white hair and cilia. On examination, bilateral hypopigmented irides, an opaque lens in the left eye, a hypopigmented fundus in the right eye, and nystagmus were found. An extra-capsular cataract extraction with posterior chamber intraocular lens (IOL) implantation was performed. After retrobulbar anesthesia was administered, the nystagmus ceased temporarily. Postoperatively, visual acuity in the left eye improved to 20/200. We believe IOL implantation is useful in the treatment of cataracts in albino patients.

Albinism, Oculocutaneous↗
PubMed1992

Timing and sequence of the events in the development of extraocular muscles in staged human embryos: ultrastructural and histochemical study.

The ultrastructure and the appearance of glycogen were studied in the extraocular muscles of 14 externally normal human embryos (Carnegie stages 13-21). At stage 16, myofibrils with an immature Z line and glycogen granules appeared in the cytoplasm of the myoblast. The myoblasts came into cluster at stage 18, and fusion between the myotubes was observed at stage 20. At this stage, an M line appeared in the myofibrils. At stage 21, an A band with a Z line and an H band with an M line were observed, the sarcoplasmic reticulum appeared in the cytoplasm of the muscle fibers and glycogen increased in volume in the cytoplasm. In the previous study, we showed that the muscle-specific isoenzymes, such as creatine kinase, beta-enolase and glycogen phosphorylase, appeared from stage 18 to 20 in the extraocular muscles. The previous findings and the present results suggest that the fusion of the muscle cells occurs in the period when some molecular markers of muscle differentiation are expressed in vivo.

Glycogen↗