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Biomedical subjects

T Setogawa

Publications and source records attributed to T Setogawa.

At least 55 records · Page 3Linked to original sources
PubMed1992

Immunohistochemical study of carbonic anhydrase III in the extraocular muscles of human embryos.

The differentiation of extraocular muscles was studied immunohistochemically in externally normal human embryos (Carnegie stages 13-23), using antibodies to carbonic anhydrase (CA) III and beta-enolase as the markers of type 1 and type 2 muscle fibers, respectively. At stage 18, some myoblasts were immunoreactive to beta-enolase antibodies, however, CA-III immunoreactivity was not observed around the optic vesicle. At stage 20, CA-III immunoreactivity appeared in some muscle fibers of extraocular muscles. From stage 21 to stage 23, CA-III-immunoreactive fibers increased and almost equalled the number of beta-enolase-immunoreactive fibers. These findings suggest that CA-III-immunoreactive type 1 fibers appear in the late stage of myogenesis compared with beta-enolase-immunoreactive type 2 fibers.

Carbonic Anhydrases↗
PubMed1992

Superficial punctate keratopathy and bacterial growth in patients with unilateral aphakia using extended-wear soft contact lenses.

We prospectively examined corneal conditions and bacterial growth in 77 individuals with unilateral aphakia who were using extended-wear soft contact lenses. The ratios of positive bacterial growth (70.6-79.4%) from 34 patients with superficial punctate keratopathy were significantly higher than those (41.9-46.5%) from the 43 subjects with normal corneas. Bacterial growth was found frequently in patients with superficial punctate keratopathy who were older than 80 years and in those using soft contact lenses for more than 22 days. Several kinds of bacteria grew from the specimens. Among the most common were Staphylococcus epidermidis and Corynebacterium species. Pseudomonas aeruginosa grew from patients with superficial punctate keratopathy who were using extended-wear soft contact lenses.

Aged↗
PubMed1992

Practically corrected visual acuity after extracapsular cataract extraction with or without intraocular lens implantation.

We examined retrospectively a total of 171 patients (236 eyes) who had undergone extracapsular cataract extraction (ECCE) with or without intraocular lens implantation (IOL). The best and practically corrected visual acuities were determined 6 months after surgery. Practically corrected visual acuity of the ECCE group was significantly worse than that of ECCE plus IOL group of patients who had undergone unilateral cataract surgery. In patients who had undergone bilateral surgery, visual improvement was almost optimal in both groups. With regard to practically corrected visual acuity, ECCE plus IOL was the preferable procedure for elderly patients who had had unilateral cataract.

Aged↗
PubMed1992

Waardenburg syndrome in Japanese patients. Case reports and literature review.

A 3-year-old girl (case 1) had a blue iris and albinotic fundus in the right eye and bilateral deafness. Her 6-month-old sister (case 2) had hypopigmented irides and fundi in both eyes and bilateral deafness. We found that the ratios of interinner canthal distance to interpupillary distance were less than 0.65 in normal Japanese controls. In our patients, these ratios were within the normal range, indicating the absence of dystopia canthorum. After reviewing the recent Japanese literature, we found that the hypopigmented iris and deafness seen in our patients are common in Japanese patients with Waardenburg syndrome.

Adult↗
PubMed1992

Fluorescein-angiographic patterns in patients with central serous chorioretinopathy at the initial visit.

We reviewed the clinical records, color photographs and fluorescein angiograms of 106 eyes of 53 patients (44 men and 9 women) with central serous chorioretinopathy who had been followed up for 1 year or more. Their ages ranged from 20 to 59 years. One eye in each patient was involved at the initial visit. According to fluorescein-angiographic findings, the lesions were divided into smokestack pattern (13 eyes), ink blot appearance (33 eyes) and minimally enlarging spot (7 eyes). Most patients complained of central scotoma, and most patients had moderately decreased visual acuities at the initial visit, which improved after recovery. In particular, all 7 eyes with a minimally enlarging spot had a visual acuity of 0.8 or more at the initial visit; of these 6 eyes had 1.0 or more several weeks later. On fluorescein angiography, 49 eyes demonstrated 1 leaking spot and 4 eyes showed 2 spots. Of 57 leaking spots, 10 were observed in the foveola, 31 were noted in the fovea and 16 were found in the para- or perifovea. Of 13 smokestack patterns, 5 were found in the inferonasal area. The ink blot appearance and minimally enlarging spots were frequently found in the superonasal and superotemporal areas.

Adult↗
PubMed1992

Leber congenital amaurosis in an infant with Down syndrome.

A male infant had defects of atrial and ventricular septa and trisomy 21. At 2 months of age, the patient had markedly sluggish pupillary reactions to light OU. Searching nystagmus, multiple chorioretinal atrophic spots in mottled retinas, and unrecordable electroretinograms also were found in the patient when he was 6 months of age. We believe that this infant represents a rare case of Leber congenital amaurosis in association with Down syndrome.

Atrophy↗
PubMed1992

Optic nerve glioma in Japanese patients with neurofibromatosis 1. Case reports and literature review.

Case 1, a 6-year-old boy, had multiple café-au-lait spots, no light perception OS, Lisch nodules OU, pale optic disc OS, enlarged left optic nerve on computed tomographic scan and magnetic resonance imaging, and histopathologically verified pilocytic astrocytoma (glioma). The patient's mother had neurofibromatosis 1 (NF-1). Case 2, a 12-year-old boy, had multiple café-au-lait spots, decreased visual acuity OU, Lisch nodules OU, pale optic discs OU, enlarged optic nerves and chiasm on computed tomographic scan, and histopathologically verified pilocytic astrocytoma. We also examined 38 Japanese patients with NF-1 and found Lisch nodules in 95% and optic nerve glioma in 5%. After reviewing the recent literature, we found that the association of optic nerve glioma and NF-1 in the Japanese population was less than that reported in North America.

Adolescent↗
PubMed1992

Ophthalmic complications in patients with malignant tumors of the nose and paranasal sinuses.

We examined 34 Japanese patients (16 men and 18 women) with malignant tumors of the nose and paranasal sinuses. Squamous cell carcinoma of the maxillary sinus was the most common tumor. During the patients' initial visits, several ophthalmic symptoms were noticed, including proptosis, epiphora, lid swelling, displacement of the globe, orbital mass, and sudden visual loss. In addition, several ocular and orbital symptoms and signs resulted from treatment with radiotherapy, chemotherapy, and surgery and from local recurrence of the tumor. Four patients underwent orbital exenteration, and one underwent evisceration. Five eyes had no light perception.

Adolescent↗
PubMed1992

Type of arteriovenous crossing at site of branch retinal vein occlusion.

A retrospective study of 63 patients (64 eyes) with symptomatic branch retinal vein occlusion, 30 men and 33 women, was carried out in this study. The ages of the subjects ranged from 40 to 82 years. Systemic hypertension was present in 41 patients and diabetes mellitus in 19. The occlusion involved the superotemporal vein in 39 eyes, inferotemporal vein in 20, superonasal vein in 2 or macular vein in 3. The site of the occlusion could be examined in detail in 57 eyes, and an arterial overcrossing was involved in 53 of these eyes (93%). This incidence of arterial overcrossing was significantly higher in the branch retinal vein occlusion eyes than in control eyes (P less than 0.05).

Adult↗
PubMed1991

Electroretinographic responses in patients with pulseless disease vary with head and body positions.

We examined bright-flash electroretinograms obtained in two Japanese women with pulseless disease. One 48-year-old woman (case 1) who has had the disease for 17 years showed no oscillatory potentials. When she sat and tilted her head to the right, a- and b-wave amplitudes diminished in the left eye. A second 48-year-old woman (case 2) who has had the disease for 10 years also demonstrated absent oscillatory potentials. When she sat and raised her chin, a- and b-wave amplitudes diminished in both eyes. These amplitudes were normal when the patients were in a supine position.

Adult↗
PubMed1991

Sex differences in host resistance to Mycobacterium marinum infection in mice.

Sex differences were observed in host resistance to Mycobacterium marinum infection in mice. Males were found to be more susceptible than females in terms of mortality, incidence of gross skin lesions, and bacterial load in the lungs and spleen. The degree of sex differences varied from strain to strain of test mice, in the order C3H/He, A/J, and BALB/c greater than DBA/2, B10.A, and C57BL/6, on the basis of survival time and multiplication of organisms in the visceral organs. Although this ordering corresponded to the susceptibilities of both male and female mice to the organisms, much greater strain dependency was seen in males than in females. Castration caused an increase in the host resistance of males, but this effect was substantially reversed by continuous testosterone treatment. Testosterone also increased the susceptibility of female mice to this infection. These findings imply that the male sex hormone is involved in the lowered anti-M. marinum resistance of males. Although athymic mice were more susceptible than euthymic mice, a substantial degree of sex difference was also observed in the T-cell-depleted animals, indicating that natural host resistance to this infection is sex dependent. Indeed, more efficient macrophage mobilization at the site of infection was seen in females than in males. Although female T-cell transplantation improved the lowered resistance of athymic mice, there was a sex difference in bacterial growth in the lungs. This implies that sex hormones affect T-cell functions.

Animals↗
PubMed1991

Retinal vasculitis in a mother and her son with human T-lymphotropic virus type 1 associated myelopathy.

A 53-year-old woman had difficulty in walking, raised titres to human T-lymphotropic virus type 1 (HTLV-1) in serum and cerebrospinal fluid, and yellowish white retinal lesions and vasculitis in the right eye. Her 20-year-old son also had difficulty in walking, raised titres to HTLV-1 in serum and cerebrospinal fluid, and retinal vasculitis and multiple whitish vitreoretinal spots in both eyes.

Adult↗
PubMed1991

Ultrastructural study on the retinal pigment epithelium of human embryos, with special reference to quantitative study on the development of melanin granules.

The development of the retinal pigment epithelium (RPE) was studied ultrastructurally, using 13 externally normal human embryos, Carnegie stages ranging from 13 to 23 (4-8 week of gestation). Melanosomes in the peripheral and posterior RPE were classified according to Fitzpatrick et al. The melanosome of phase I is formed from the Golgi complex and parcelled off into small vesicles. The vesicle enlarges and elongates to form an oval organelle with membranous structures in it (phase II melanosome). Subsequently, melanin deposits on the membranous structures of the melanosomes (phase III melanosomes), and the completion of this process produces a uniformly electrondense granule without discernible internal structures (phase IV melanosome). Melanosomes of phases III and IV appeared in the RPE at stage 15. As the embryonic stage advanced, the ratio of phase II melanosomes decreased and that of phase IV melanosomes increased. The number of phase III melanosomes reached a peak in the peripheral and posterior RPE at stages 15 and 18, respectively. After stage 17, the increase in melanosomes and intracellular organelles was more prominent in the posterior than in the peripheral RPE. During stages 13 and 15, gap junctions were present not only in the apical but also basal plasma membranes of the RPE. At stage 20, gap junctions in the basal plasma membrane disappeared except for the transitional areas from the RPE to the neural retina (NR). In addition, gap junctions were observed between NR and RPE only in the peripheral region at stage 20. The morphological and quantitative differences in the peripheral and posterior RPE in the embryonic period are discussed.

Cytoplasmic Granules↗
PubMed1991

Polymorphonuclear leukocytes and bacterial growth of the normal and mildly inflamed conjunctiva.

We examined 304 conjunctiva in 152 subjects by clinical, cytologic, and bacteriologic methods. Bacteriologic samples were evaluated after a 48-hour incubation. Bacterial growth was found in 8 (20.5%) of 39 patients with clinically normal conjunctiva and no polymorphonuclear leukocytes (PMNs), and in 8 (61.5%) of 13 subjects with clinically normal conjunctiva and evidence of PMNs. Bacterial growth also was observed in 4 (40.0%) of 10 patients with clinically mild conjunctivitis and no PMNs, in 10 (24.4%) of 41 patients with clinically mild conjunctivitis and a mixture of inflammatory cells or predominantly lymphocytes, and in 37 (75.5%) of 49 patients with clinically mild conjunctivitis and evidence of PMNs. The presence of PMNs was well correlated with the existence of rapid-growing bacteria.

Adolescent↗
PubMed1991

Foster Kennedy syndrome and optociliary shunt vessels in a patient with an olfactory groove meningioma.

A 48-year-old woman complained of acute loss of vision in her right eye. Ophthalmoscopically, the right optic disk appeared pale, and abnormally dilated vessels were noted on the disk. The left optic disk was reddish and swollen. Fluorescein angiography revealed abnormal vessels on the right optic disk that might be venous. The patient had right-sided anosmia. Computed tomography and magnetic resonance imaging showed a lesion in the frontal lobe that was deviated to the right and attached to the olfactory groove. A histopathologic study of the excised specimen disclosed a meningioma. We believe that this patient with olfactory groove meningioma represents a rare case of Foster Kennedy syndrome and optociliary shunt vessels.

Ciliary Body↗