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Biomedical subjects

T Shono

Publications and source records attributed to T Shono.

122 records · Page 7Linked to original sources
PubMed1981

Serum apoprotein A-I and A-II levels in liver diseases and cholestasis.

Serum apoprotein A-I and A-II levels were determined by electroimmunoassay in patients with liver diseases and cholestasis. Significant decreases in apoprotein A-I and A-II levels were observed in such patients. The decreases were especially pronounced in the early phase of acute hepatitis and cholestasis. The decreases in A-II levels were more prominent than the decreases in A-I in severe hepatic dysfunction or cholestasis. Accordingly, the A-I/A-II ratio showed no change in the convalescent phase of acute hepatitis or chronic hepatitis but increased significantly in the early phase of acute hepatitis, cirrhosis of the liver, hepatoma, and cholestasis. The results suggested the existence of a high density lipoprotein with an abnormal apoprotein composition or a more profound decrease of HDL3 than of HDL2 in severe hepatocellular dysfunction of cholestasis.

Adult↗
PubMedDate not supplied

Clinical characteristics and natural history of antenatally diagnosed fetal uropathy. An analysis of 55 cases.

The clinical characteristics and natural history of 55 cases with antenatally diagnosed fetal uropathy were investigated. Percutaneous aspiration of the fetal pelvic or vesical urine was performed to decompress progressive unilateral hydronephrosis in 2 cases and to evaluate renal function in another 2 cases of bilateral hydronephrosis. As the postnatal diagnosis, upper urinary tract dilatation (hydronephrosis or hydronephroureter, 33 cases) and renal dysplasia (15 cases) made up 87% of all cases. A combination of hydronephrosis in one kidney and renal dysplasia in the other was also found in another 2 cases. Among 35 cases with upper urinary tract dilatation, 27 cases demonstrated pelviureteric junction stenosis and surgical intervention was necessary in 15 cases. In 17 cases with renal dysplasia, spontaneous regression was observed in only 3 cases and surgical intervention by means of percutaneous nephrostomy and nephrectomy was performed in 4 and 6 cases, respectively.

Constriction, Pathologic↗
PubMedDate not supplied

Regioselectivity and reactivity in microsomal hydroxylation of a series of N-acyl- and N-sulfonylamines in rats.

Regioselectivity and overall reactivity in the hydroxylation of a series of substituted N-benzoyl- and benzenesulfonyl aliphatic and alicyclic amines with rat liver microsomes were investigated. The hydroxylation occurred predominantly at the position gamma to the nitrogen atom. para-Alkyl-substituted benzoylamines were hydroxylated at both the benzylic positions as well as the gamma-position, whereas para-substituted benzenesulfonylamines were hydroxylated mainly at the benzylic position. The relative overall reactivity of primary, secondary, and tertiary carbon atoms was about 1:3:8, and the contribution of substituents adjoining to the reaction site was negligible. Benzylic hydroxylation proceeded stereoselectively, whereas gamma-hydroxylation gave optically inactive metabolites; the inter- and intramolecular isotope effects in the hydroxylation were 1.6 and 7.2, respectively.

Animals↗
PubMedDate not supplied

Monkey pulpal response to adhesively luted indirect resin composite inlays.

Monkey pulpal responses to resin-bonded indirect resin composite inlays were histopathologically evaluated by placing them in either etched-enamel, total-etched, or adhesive-resin-lined cavities. Initial pulpal responses caused by re-exposure of the cut dentin surfaces and luting procedure subsided if a tight marginal seal was secured by final cementation of the inlay. The adhesive resin coating of freshly cut dentinal walls/floors seems to provide a new technique to protect the dentin and pulp in indirect restorations requiring temporary sealing.

Analysis of Variance↗
PubMedDate not supplied

Microporous dentin zone beneath resin-impregnated layer.

The purpose of this study was to investigate marginal microleakage by examining the resin/dentin interface using a cryo-SEM and a silver ion penetration method. Class 5 cervical cavities were restored using an adhesive resin system following treatment with 37% phosphoric acid gel. The cavity wall adaptation was observed using cryo-SEM to avoid specimen damage. This observation showed excellent marginal adaptation of material to cavity walls and no gap formation. However, silver ions had penetrated beneath the resin-impregnated layer when observed with conventional SEM images, which showed the leakage of silver ions between the resin and decalcified tooth structure without gap formation. This study suggests that the bonding monomers of Clearfil Photo Bond were not fully able to penetrate into the demineralized dentin after phosphoric acid etching, thus leaving a porous zone as a microleakage pathway beneath the resin-impregnated layer.

Acid Etching, Dental↗